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• W4387121104 abstract "Background African animal trypanosomiasis hinders sustainable livestock productivity in sub-Saharan Africa. About 17 million infected cattle are treated with trypanocides annually but most of the drugs are associated with drawbacks, necessitating the search for a promising chemotherapeutic agent. Objectives In this study, the effects of β-sitosterol on Trypanosoma congolense infection were investigated along with its effect on the trans-sialidase gene expressions. Results Oral treatment with β-sitosterol at 15 and 30 mg/kg body weight (BW) for 14 days significantly ( p &lt; 0.05) reduced parasitemia and ameliorated the parasite-induced anemia. Also, the parasite-induced increase in serum urea level and renal histopathological damage scores in addition to renal hypertrophy was significantly ( p &lt; 0.05) reverted following treatment with 30 mg/kg BW β-sitosterol. The compound also significantly ( p &lt; 0.05) down-regulated the expression of TconTS1 but not TconTS2 , TconTS3 , and TconTS4 . Correlation analysis between free serum sialic acid with the TconTS1 and TconTS2 gene variants revealed negative correlations in the β-sitosterol-treated groups although they were non-significant ( p &gt; 0.05) in the group treated with 15 mg/kg BW β-sitosterol. Similarly, a non-significant negative ( p &gt; 0.05) correlation between the biomolecule and the TconTS3 and TconTS4 gene variants was observed in the β-sitosterol-treated groups while positive correlations were observed in the infected untreated control group. Conclusion The observed effect of β-sitosterol on T. congolense infection could make the compound a possible template for the design of novel trypanocides." @default.
• W4387121104 created "2023-09-29" @default.
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• W4387121104 date "2023-09-27" @default.
• W4387121104 modified "2023-10-12" @default.
• W4387121104 title "Therapeutic efficacy of β-sitosterol treatment on Trypanosoma congolense infection, anemia development, and trans-sialidase (TconTS1) gene expression" @default.
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• W4387121104 doi "https://doi.org/10.3389/fmicb.2023.1282257" @default.
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