Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387121448> ?p ?o ?g. }
- W4387121448 abstract "ABSTRACT Antigenic drift of SARS-CoV-2 is typically defined by mutations in the N-terminal domain and receptor binding domain of spike protein. In contrast, whether antigenic drift occurs in the S2 domain remains largely elusive. Here, we perform a deep mutational scanning experiment to identify S2 mutations that affect binding of SARS-CoV-2 spike to three S2 apex public antibodies. Our results indicate that spatially diverse mutations, including D950N and Q954H, which are observed in Delta and Omicron variants, respectively, weaken the binding of spike to these antibodies. Although S2 apex antibodies are known to be non-neutralizing, we show that they confer partial protection in vivo . We further demonstrate that such in vivo protection activity is diminished by the natural mutation D950N. Overall, this study indicates that the S2 domain of SARS-CoV-2 spike can undergo antigenic drift, which represents a potential challenge for the development of more universal coronavirus vaccines." @default.
- W4387121448 created "2023-09-29" @default.
- W4387121448 creator A5020072810 @default.
- W4387121448 creator A5037737527 @default.
- W4387121448 creator A5051474892 @default.
- W4387121448 creator A5057665265 @default.
- W4387121448 creator A5063203922 @default.
- W4387121448 creator A5065406786 @default.
- W4387121448 creator A5067493639 @default.
- W4387121448 date "2023-09-28" @default.
- W4387121448 modified "2023-10-06" @default.
- W4387121448 title "Evidence of antigenic drift in the fusion machinery core of SARS-CoV-2 spike" @default.
- W4387121448 cites W2128711701 @default.
- W4387121448 cites W2163135112 @default.
- W4387121448 cites W2491683774 @default.
- W4387121448 cites W2605343262 @default.
- W4387121448 cites W2805385842 @default.
- W4387121448 cites W2998397491 @default.
- W4387121448 cites W3009335299 @default.
- W4387121448 cites W3034680516 @default.
- W4387121448 cites W3041564586 @default.
- W4387121448 cites W3092501606 @default.
- W4387121448 cites W3128154910 @default.
- W4387121448 cites W3129651179 @default.
- W4387121448 cites W3136693147 @default.
- W4387121448 cites W3160471157 @default.
- W4387121448 cites W3171375949 @default.
- W4387121448 cites W3176441117 @default.
- W4387121448 cites W3182696180 @default.
- W4387121448 cites W3189387362 @default.
- W4387121448 cites W3192545069 @default.
- W4387121448 cites W3203433659 @default.
- W4387121448 cites W4200274151 @default.
- W4387121448 cites W4206109384 @default.
- W4387121448 cites W4206898072 @default.
- W4387121448 cites W4220738744 @default.
- W4387121448 cites W4221027163 @default.
- W4387121448 cites W4225822226 @default.
- W4387121448 cites W4281298256 @default.
- W4387121448 cites W4283720778 @default.
- W4387121448 cites W4285041350 @default.
- W4387121448 cites W4285041384 @default.
- W4387121448 cites W4288067813 @default.
- W4387121448 cites W4289783372 @default.
- W4387121448 cites W4308443024 @default.
- W4387121448 cites W4308929796 @default.
- W4387121448 cites W4309244738 @default.
- W4387121448 cites W4317212025 @default.
- W4387121448 cites W4318149623 @default.
- W4387121448 cites W4320497972 @default.
- W4387121448 cites W4321112414 @default.
- W4387121448 cites W4321434363 @default.
- W4387121448 cites W4362733387 @default.
- W4387121448 cites W4363648471 @default.
- W4387121448 cites W4377983650 @default.
- W4387121448 doi "https://doi.org/10.1101/2023.09.27.559757" @default.
- W4387121448 hasPublicationYear "2023" @default.
- W4387121448 type Work @default.
- W4387121448 citedByCount "0" @default.
- W4387121448 crossrefType "posted-content" @default.
- W4387121448 hasAuthorship W4387121448A5020072810 @default.
- W4387121448 hasAuthorship W4387121448A5037737527 @default.
- W4387121448 hasAuthorship W4387121448A5051474892 @default.
- W4387121448 hasAuthorship W4387121448A5057665265 @default.
- W4387121448 hasAuthorship W4387121448A5063203922 @default.
- W4387121448 hasAuthorship W4387121448A5065406786 @default.
- W4387121448 hasAuthorship W4387121448A5067493639 @default.
- W4387121448 hasBestOaLocation W43871214481 @default.
- W4387121448 hasConcept C104317684 @default.
- W4387121448 hasConcept C142724271 @default.
- W4387121448 hasConcept C147483822 @default.
- W4387121448 hasConcept C159047783 @default.
- W4387121448 hasConcept C159654299 @default.
- W4387121448 hasConcept C162324750 @default.
- W4387121448 hasConcept C187736073 @default.
- W4387121448 hasConcept C2777648638 @default.
- W4387121448 hasConcept C2779134260 @default.
- W4387121448 hasConcept C2781390188 @default.
- W4387121448 hasConcept C2909509916 @default.
- W4387121448 hasConcept C3007834351 @default.
- W4387121448 hasConcept C3008058167 @default.
- W4387121448 hasConcept C501734568 @default.
- W4387121448 hasConcept C524204448 @default.
- W4387121448 hasConcept C54355233 @default.
- W4387121448 hasConcept C71924100 @default.
- W4387121448 hasConcept C86803240 @default.
- W4387121448 hasConceptScore W4387121448C104317684 @default.
- W4387121448 hasConceptScore W4387121448C142724271 @default.
- W4387121448 hasConceptScore W4387121448C147483822 @default.
- W4387121448 hasConceptScore W4387121448C159047783 @default.
- W4387121448 hasConceptScore W4387121448C159654299 @default.
- W4387121448 hasConceptScore W4387121448C162324750 @default.
- W4387121448 hasConceptScore W4387121448C187736073 @default.
- W4387121448 hasConceptScore W4387121448C2777648638 @default.
- W4387121448 hasConceptScore W4387121448C2779134260 @default.
- W4387121448 hasConceptScore W4387121448C2781390188 @default.
- W4387121448 hasConceptScore W4387121448C2909509916 @default.
- W4387121448 hasConceptScore W4387121448C3007834351 @default.
- W4387121448 hasConceptScore W4387121448C3008058167 @default.
- W4387121448 hasConceptScore W4387121448C501734568 @default.