Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387122594> ?p ?o ?g. }
- W4387122594 abstract "Abstract The complex genetic mechanisms underlying human ovary development can give rise to clinical phenotypes if disrupted, such as Primary Ovarian Insufficiency and Differences of Sex Development. Through a clinically-focused lens, we combine single-nuclei RNA sequencing, bulk RNA sequencing, and micro-focus computed tomography to elucidate the anatomy and transcriptional landscape of the human fetal ovary across key developmental timepoints (Carnegie Stage 22 until 20 weeks post conception). We show the marked growth and distinct morphological changes within the fetal ovary at the critical timepoint of germ cell expansion, and demonstrate that the fetal ovary becomes more transcriptomically distinct from the testis with age. We describe novel ovary developmental pathways, relating to neuroendocrine signalling, energy homeostasis, mitochondrial networks, piRNA processes, and inflammasome regulation. We define transcriptional regulators and candidate genes for meiosis within the developing ovary. Together, this work advances our fundamental understanding of human ovary development and clinical ovarian insufficiency phenotypes." @default.
- W4387122594 created "2023-09-29" @default.
- W4387122594 creator A5003067518 @default.
- W4387122594 creator A5005285642 @default.
- W4387122594 creator A5008209752 @default.
- W4387122594 creator A5008645373 @default.
- W4387122594 creator A5025250567 @default.
- W4387122594 creator A5029295954 @default.
- W4387122594 creator A5035173462 @default.
- W4387122594 creator A5040619746 @default.
- W4387122594 creator A5049210258 @default.
- W4387122594 creator A5064729919 @default.
- W4387122594 creator A5072530330 @default.
- W4387122594 creator A5080191840 @default.
- W4387122594 creator A5089222735 @default.
- W4387122594 creator A5090357582 @default.
- W4387122594 creator A5092958325 @default.
- W4387122594 creator A5039956277 @default.
- W4387122594 date "2023-09-28" @default.
- W4387122594 modified "2023-10-06" @default.
- W4387122594 title "Mapping the anatomical and transcriptional landscape of early human fetal ovary development" @default.
- W4387122594 cites W1978380407 @default.
- W4387122594 cites W1980513306 @default.
- W4387122594 cites W1982171656 @default.
- W4387122594 cites W1987339636 @default.
- W4387122594 cites W2012034410 @default.
- W4387122594 cites W2028884467 @default.
- W4387122594 cites W2038649350 @default.
- W4387122594 cites W2049424035 @default.
- W4387122594 cites W2065980886 @default.
- W4387122594 cites W2073540637 @default.
- W4387122594 cites W2073990533 @default.
- W4387122594 cites W2079534879 @default.
- W4387122594 cites W2111893619 @default.
- W4387122594 cites W2123037811 @default.
- W4387122594 cites W2124943870 @default.
- W4387122594 cites W2130698085 @default.
- W4387122594 cites W2132710709 @default.
- W4387122594 cites W2133734382 @default.
- W4387122594 cites W2138207763 @default.
- W4387122594 cites W2145024369 @default.
- W4387122594 cites W2155361997 @default.
- W4387122594 cites W2156714600 @default.
- W4387122594 cites W2163194305 @default.
- W4387122594 cites W2164935520 @default.
- W4387122594 cites W2179438025 @default.
- W4387122594 cites W2406250479 @default.
- W4387122594 cites W2521260605 @default.
- W4387122594 cites W2602956031 @default.
- W4387122594 cites W2604532050 @default.
- W4387122594 cites W2767802401 @default.
- W4387122594 cites W2786643590 @default.
- W4387122594 cites W2807719714 @default.
- W4387122594 cites W2912420423 @default.
- W4387122594 cites W2928665623 @default.
- W4387122594 cites W2947106191 @default.
- W4387122594 cites W2950259730 @default.
- W4387122594 cites W2953227112 @default.
- W4387122594 cites W2972786294 @default.
- W4387122594 cites W2979705485 @default.
- W4387122594 cites W3014596582 @default.
- W4387122594 cites W3027483896 @default.
- W4387122594 cites W3033061681 @default.
- W4387122594 cites W3046805499 @default.
- W4387122594 cites W3093030281 @default.
- W4387122594 cites W3149970101 @default.
- W4387122594 cites W3155640781 @default.
- W4387122594 cites W3164692211 @default.
- W4387122594 cites W3165105296 @default.
- W4387122594 cites W3193780419 @default.
- W4387122594 cites W3209461388 @default.
- W4387122594 cites W4220835951 @default.
- W4387122594 cites W4220995320 @default.
- W4387122594 cites W4226322299 @default.
- W4387122594 cites W4284885575 @default.
- W4387122594 cites W4296663219 @default.
- W4387122594 cites W4307034884 @default.
- W4387122594 cites W4308039765 @default.
- W4387122594 cites W4313245319 @default.
- W4387122594 cites W4318982686 @default.
- W4387122594 cites W4322153987 @default.
- W4387122594 doi "https://doi.org/10.1101/2023.09.26.558771" @default.
- W4387122594 hasPublicationYear "2023" @default.
- W4387122594 type Work @default.
- W4387122594 citedByCount "0" @default.
- W4387122594 crossrefType "posted-content" @default.
- W4387122594 hasAuthorship W4387122594A5003067518 @default.
- W4387122594 hasAuthorship W4387122594A5005285642 @default.
- W4387122594 hasAuthorship W4387122594A5008209752 @default.
- W4387122594 hasAuthorship W4387122594A5008645373 @default.
- W4387122594 hasAuthorship W4387122594A5025250567 @default.
- W4387122594 hasAuthorship W4387122594A5029295954 @default.
- W4387122594 hasAuthorship W4387122594A5035173462 @default.
- W4387122594 hasAuthorship W4387122594A5039956277 @default.
- W4387122594 hasAuthorship W4387122594A5040619746 @default.
- W4387122594 hasAuthorship W4387122594A5049210258 @default.
- W4387122594 hasAuthorship W4387122594A5064729919 @default.
- W4387122594 hasAuthorship W4387122594A5072530330 @default.
- W4387122594 hasAuthorship W4387122594A5080191840 @default.
- W4387122594 hasAuthorship W4387122594A5089222735 @default.