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- W4387126075 abstract "ABSTRACT The relationship between adiposity and dopamine type-2 receptor binding potential (D2BP) in the human brain has been repeatedly studied for >20 years with highly discrepant results, likely due to variable methodologies and differing study populations. We conducted a controlled inpatient feeding study to measure D2BP in the striatum using positron emission tomography with both [ 18 F]fallypride and [ 11 C]raclopride in pseudo-random order in 54 young adults with a wide range of body mass index (BMI 20-44 kg/m 2 ). Within-subject D2BP measurements using the two tracers were moderately correlated (r=0.47, p<0.001). D2BP was negatively correlated with BMI as measured by [ 11 C]raclopride (r= -0.51; p<0.0001) but not [ 18 F]fallypride (r=-0.01; p=0.92) and these correlation coefficients were significantly different from each other (p<0.001). Given that [ 18 F]fallypride has greater binding affinity to dopamine type-2 receptors than [ 11 C]raclopride, which is more easily displaced by endogenous dopamine, our results suggest that adiposity is positively associated with increased striatal dopamine tone." @default.
- W4387126075 created "2023-09-29" @default.
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- W4387126075 date "2023-09-28" @default.
- W4387126075 modified "2023-10-03" @default.
- W4387126075 title "Striatal dopamine tone is positively associated with body mass index in humans as determined by PET using dual dopamine type-2 receptor antagonist tracers" @default.
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- W4387126075 doi "https://doi.org/10.1101/2023.09.27.23296169" @default.
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