FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387129440> ?p ?o ?g. }

• W4387129440 endingPage "37139" @default.
• W4387129440 startingPage "37128" @default.
• W4387129440 abstract "Geraniol (GER) is a plant-derived acyclic isoprenoid monoterpene that has displayed anti-inflammatory effects in numerous in vivo and in vitro models. This study was therefore designed to evaluate the antiarthritic potential of GER in complete Freund's adjuvant (CFA)-induced inflammatory arthritis (IA) model in rats. IA was induced by intraplantar injection of CFA (0.1 mL), and a week after CFA administration, rats were treated with various doses of methotrexate (MTX; 1 mg/kg) or GER (25, 50, and 100 mg/kg). Treatments were given on every alternate day, and animals were sacrificed on the 35th day. Paw volume, histopathological, hematological, radiographic, and qPCR analyses were performed to analyze the severity of the disease. GER significantly reduced paw edema after 35 days of treatment, and these results were comparable to the MTX-treated group. GER-treated animals displayed a perfect joint structure with minimal inflammation and no signs of cartilage or bone damage. Moreover, GER restored red blood cell and hemoglobin levels, normalized erythrocyte sedimentation rate, platelet, and c-reactive protein values, and also attenuated the levels of rheumatoid factor. RT-qPCR analysis demonstrated that GER decreased mRNA expression of pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta. GER also down-regulated the transcript levels of cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1, prostaglandin D2 synthase, and interstitial collagenase (MMP-1). Molecular docking of GER with COX-2, TNF-α, and MMP-1 also revealed that the antiarthritic effects of GER could be due to its direct interactions with these mediators. Based on our findings, it is conceivable that the antiarthritic effects of GER could be attributed to downregulation of pro-inflammatory mediators and protease like MMP-1." @default.
• W4387129440 created "2023-09-29" @default.
• W4387129440 creator A5004701218 @default.
• W4387129440 creator A5008820069 @default.
• W4387129440 creator A5014019758 @default.
• W4387129440 creator A5021200402 @default.
• W4387129440 creator A5031112818 @default.
• W4387129440 creator A5033671360 @default.
• W4387129440 creator A5045223632 @default.
• W4387129440 creator A5046694463 @default.
• W4387129440 creator A5058394179 @default.
• W4387129440 creator A5059481127 @default.
• W4387129440 creator A5060615406 @default.
• W4387129440 creator A5080556228 @default.
• W4387129440 creator A5086617764 @default.
• W4387129440 creator A5091999982 @default.
• W4387129440 date "2023-09-28" @default.
• W4387129440 modified "2023-10-18" @default.
• W4387129440 title "Geraniol Suppresses Oxidative Stress, Inflammation, and Interstitial Collagenase to Protect against Inflammatory Arthritis" @default.
• W4387129440 cites W1510685779 @default.
• W4387129440 cites W1521338784 @default.
• W4387129440 cites W1524005872 @default.
• W4387129440 cites W1586192659 @default.
• W4387129440 cites W1586814698 @default.
• W4387129440 cites W164408329 @default.
• W4387129440 cites W1701993624 @default.
• W4387129440 cites W1714506000 @default.
• W4387129440 cites W1827550384 @default.
• W4387129440 cites W1858465734 @default.
• W4387129440 cites W1873126901 @default.
• W4387129440 cites W1962151850 @default.
• W4387129440 cites W1965151258 @default.
• W4387129440 cites W1974878649 @default.
• W4387129440 cites W1975230923 @default.
• W4387129440 cites W1996820975 @default.
• W4387129440 cites W1997282832 @default.
• W4387129440 cites W2000770184 @default.
• W4387129440 cites W2001699070 @default.
• W4387129440 cites W2002593275 @default.
• W4387129440 cites W2003599597 @default.
• W4387129440 cites W2008861688 @default.
• W4387129440 cites W2016950635 @default.
• W4387129440 cites W2022268100 @default.
• W4387129440 cites W2033402874 @default.
• W4387129440 cites W2042570856 @default.
• W4387129440 cites W2042663666 @default.
• W4387129440 cites W2047217668 @default.
• W4387129440 cites W2073856508 @default.
• W4387129440 cites W2093440953 @default.
• W4387129440 cites W2110826367 @default.
• W4387129440 cites W2120857280 @default.
• W4387129440 cites W2121932492 @default.
• W4387129440 cites W2123333870 @default.
• W4387129440 cites W2131029818 @default.
• W4387129440 cites W2131872753 @default.
• W4387129440 cites W2134967712 @default.
• W4387129440 cites W2142497985 @default.
• W4387129440 cites W2163720085 @default.
• W4387129440 cites W2170790620 @default.
• W4387129440 cites W2293421874 @default.
• W4387129440 cites W2299383924 @default.
• W4387129440 cites W2321994053 @default.
• W4387129440 cites W2337797030 @default.
• W4387129440 cites W2338639329 @default.
• W4387129440 cites W2409262985 @default.
• W4387129440 cites W2519293830 @default.
• W4387129440 cites W2543815471 @default.
• W4387129440 cites W2549510815 @default.
• W4387129440 cites W2735527928 @default.
• W4387129440 cites W2748648412 @default.
• W4387129440 cites W2756207290 @default.
• W4387129440 cites W2783475872 @default.
• W4387129440 cites W2795502752 @default.
• W4387129440 cites W2803973097 @default.
• W4387129440 cites W2897097398 @default.
• W4387129440 cites W2901915549 @default.
• W4387129440 cites W2902282891 @default.
• W4387129440 cites W2912987869 @default.
• W4387129440 cites W2970433419 @default.
• W4387129440 cites W2982006909 @default.
• W4387129440 cites W3006080604 @default.
• W4387129440 cites W3013800548 @default.
• W4387129440 cites W3021389063 @default.
• W4387129440 cites W3024111287 @default.
• W4387129440 cites W3112545085 @default.
• W4387129440 cites W3162210444 @default.
• W4387129440 cites W3209722108 @default.
• W4387129440 cites W341380709 @default.
• W4387129440 cites W4200405895 @default.
• W4387129440 cites W4224133664 @default.
• W4387129440 cites W4285719527 @default.
• W4387129440 cites W4300462081 @default.
• W4387129440 doi "https://doi.org/10.1021/acsomega.3c04684" @default.
• W4387129440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37841186" @default.
• W4387129440 hasPublicationYear "2023" @default.
• W4387129440 type Work @default.
• W4387129440 citedByCount "0" @default.
• W4387129440 crossrefType "journal-article" @default.

• next