Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387130500> ?p ?o ?g. }
- W4387130500 abstract "Non-coding RNAs (ncRNAs) are transcribed throughout the genome and provide regulatory inputs to gene expression through their interaction with chromatin. Yet, the genomic targets and functions of most ncRNAs are unknown. Here we use chromatin-associated RNA sequencing (ChAR-seq) to map the global network of ncRNA interactions with chromatin in human embryonic stem cells and the dynamic changes in interactions during differentiation into definitive endoderm. We uncover general principles governing the organization of the RNA-chromatin interactome, demonstrating that nearly all ncRNAs exclusively interact with genes in close three-dimensional proximity to their locus and provide a model predicting the interactome. We uncover RNAs that interact with many loci across the genome and unveil thousands of unannotated RNAs that dynamically interact with chromatin. By relating the dynamics of the interactome to changes in gene expression, we demonstrate that activation or repression of individual genes is unlikely to be controlled by a single ncRNA." @default.
- W4387130500 created "2023-09-29" @default.
- W4387130500 creator A5022996455 @default.
- W4387130500 creator A5043393854 @default.
- W4387130500 creator A5057175998 @default.
- W4387130500 creator A5058402194 @default.
- W4387130500 creator A5067966000 @default.
- W4387130500 creator A5088076037 @default.
- W4387130500 date "2023-09-28" @default.
- W4387130500 modified "2023-10-17" @default.
- W4387130500 title "Global mapping of RNA-chromatin contacts reveals a proximity-dominated connectivity model for ncRNA-gene interactions" @default.
- W4387130500 cites W1739743960 @default.
- W4387130500 cites W1816176398 @default.
- W4387130500 cites W1882171616 @default.
- W4387130500 cites W1964268598 @default.
- W4387130500 cites W1969161156 @default.
- W4387130500 cites W1973062929 @default.
- W4387130500 cites W1986223165 @default.
- W4387130500 cites W2014787267 @default.
- W4387130500 cites W2015845481 @default.
- W4387130500 cites W2017844161 @default.
- W4387130500 cites W2021333801 @default.
- W4387130500 cites W2028083716 @default.
- W4387130500 cites W2029080366 @default.
- W4387130500 cites W2030030642 @default.
- W4387130500 cites W2053855164 @default.
- W4387130500 cites W2054677853 @default.
- W4387130500 cites W2058970225 @default.
- W4387130500 cites W2059968749 @default.
- W4387130500 cites W2070021921 @default.
- W4387130500 cites W2074884450 @default.
- W4387130500 cites W2080055531 @default.
- W4387130500 cites W2082161548 @default.
- W4387130500 cites W2084990854 @default.
- W4387130500 cites W2090037139 @default.
- W4387130500 cites W2094468530 @default.
- W4387130500 cites W2096010243 @default.
- W4387130500 cites W2110917704 @default.
- W4387130500 cites W2113999582 @default.
- W4387130500 cites W2114029110 @default.
- W4387130500 cites W2125577657 @default.
- W4387130500 cites W2126504590 @default.
- W4387130500 cites W2129375421 @default.
- W4387130500 cites W2132953391 @default.
- W4387130500 cites W2133205307 @default.
- W4387130500 cites W2134625814 @default.
- W4387130500 cites W2152605077 @default.
- W4387130500 cites W2152623715 @default.
- W4387130500 cites W2167491742 @default.
- W4387130500 cites W2171808845 @default.
- W4387130500 cites W2175884649 @default.
- W4387130500 cites W2179438025 @default.
- W4387130500 cites W2276045700 @default.
- W4387130500 cites W2300506866 @default.
- W4387130500 cites W2527981347 @default.
- W4387130500 cites W2536839675 @default.
- W4387130500 cites W2540331622 @default.
- W4387130500 cites W2558404077 @default.
- W4387130500 cites W2564487483 @default.
- W4387130500 cites W2578822114 @default.
- W4387130500 cites W2581106675 @default.
- W4387130500 cites W2582023661 @default.
- W4387130500 cites W2620819500 @default.
- W4387130500 cites W2625626396 @default.
- W4387130500 cites W2626627929 @default.
- W4387130500 cites W2729766313 @default.
- W4387130500 cites W2740520136 @default.
- W4387130500 cites W2747089052 @default.
- W4387130500 cites W2749706640 @default.
- W4387130500 cites W2750416916 @default.
- W4387130500 cites W2755353730 @default.
- W4387130500 cites W2789834529 @default.
- W4387130500 cites W2806123558 @default.
- W4387130500 cites W2863481345 @default.
- W4387130500 cites W2883217678 @default.
- W4387130500 cites W2886278803 @default.
- W4387130500 cites W2889032805 @default.
- W4387130500 cites W2917676706 @default.
- W4387130500 cites W2951525917 @default.
- W4387130500 cites W2954785163 @default.
- W4387130500 cites W2968777178 @default.
- W4387130500 cites W2971029111 @default.
- W4387130500 cites W2972617700 @default.
- W4387130500 cites W2995527562 @default.
- W4387130500 cites W2996485440 @default.
- W4387130500 cites W2997428515 @default.
- W4387130500 cites W3008598131 @default.
- W4387130500 cites W3011709397 @default.
- W4387130500 cites W3013371767 @default.
- W4387130500 cites W3037095441 @default.
- W4387130500 cites W3037659659 @default.
- W4387130500 cites W3043555397 @default.
- W4387130500 cites W3045910546 @default.
- W4387130500 cites W3046003662 @default.
- W4387130500 cites W3082835910 @default.
- W4387130500 cites W3083694860 @default.
- W4387130500 cites W3115880421 @default.
- W4387130500 cites W3125946770 @default.
- W4387130500 cites W3155911001 @default.
- W4387130500 cites W3159056526 @default.