Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387130504> ?p ?o ?g. }
- W4387130504 endingPage "1464" @default.
- W4387130504 startingPage "1453" @default.
- W4387130504 abstract "Integrin-mediated focal adhesions are the primary architectures that transmit forces between the extracellular matrix (ECM) and the actin cytoskeleton. Although focal adhesions are abundant on rigid and flat substrates that support high mechanical tensions, they are sparse in soft three-dimensional (3D) environments. Here we report curvature-dependent integrin-mediated adhesions called curved adhesions. Their formation is regulated by the membrane curvatures imposed by the topography of ECM protein fibres. Curved adhesions are mediated by integrin ɑvβ5 and are molecularly distinct from focal adhesions and clathrin lattices. The molecular mechanism involves a previously unknown interaction between integrin β5 and a curvature-sensing protein, FCHo2. We find that curved adhesions are prevalent in physiological conditions, and disruption of curved adhesions inhibits the migration of some cancer cell lines in 3D fibre matrices. These findings provide a mechanism for cell anchorage to natural protein fibres and suggest that curved adhesions may serve as a potential therapeutic target." @default.
- W4387130504 created "2023-09-29" @default.
- W4387130504 creator A5014172825 @default.
- W4387130504 creator A5034999320 @default.
- W4387130504 creator A5035339773 @default.
- W4387130504 creator A5037547547 @default.
- W4387130504 creator A5043184378 @default.
- W4387130504 creator A5047221605 @default.
- W4387130504 creator A5048840728 @default.
- W4387130504 creator A5049692788 @default.
- W4387130504 creator A5076699095 @default.
- W4387130504 creator A5089758283 @default.
- W4387130504 date "2023-09-28" @default.
- W4387130504 modified "2023-10-15" @default.
- W4387130504 title "Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions" @default.
- W4387130504 cites W1486952955 @default.
- W4387130504 cites W1502865841 @default.
- W4387130504 cites W1811064827 @default.
- W4387130504 cites W1964171893 @default.
- W4387130504 cites W1965933207 @default.
- W4387130504 cites W1967634026 @default.
- W4387130504 cites W1968409252 @default.
- W4387130504 cites W1973796847 @default.
- W4387130504 cites W1982447134 @default.
- W4387130504 cites W1993006648 @default.
- W4387130504 cites W1995977950 @default.
- W4387130504 cites W1996645671 @default.
- W4387130504 cites W2041848251 @default.
- W4387130504 cites W2052823397 @default.
- W4387130504 cites W2057989196 @default.
- W4387130504 cites W2058624823 @default.
- W4387130504 cites W2077087448 @default.
- W4387130504 cites W2088244160 @default.
- W4387130504 cites W2090341826 @default.
- W4387130504 cites W2101244168 @default.
- W4387130504 cites W2105308973 @default.
- W4387130504 cites W2152147931 @default.
- W4387130504 cites W2188169307 @default.
- W4387130504 cites W2211191608 @default.
- W4387130504 cites W2263829954 @default.
- W4387130504 cites W2327893020 @default.
- W4387130504 cites W2346331532 @default.
- W4387130504 cites W2613629789 @default.
- W4387130504 cites W2621590149 @default.
- W4387130504 cites W2627003929 @default.
- W4387130504 cites W2734694910 @default.
- W4387130504 cites W2755607735 @default.
- W4387130504 cites W2875380647 @default.
- W4387130504 cites W2891465278 @default.
- W4387130504 cites W2897037924 @default.
- W4387130504 cites W2901606464 @default.
- W4387130504 cites W2945604056 @default.
- W4387130504 cites W2951737903 @default.
- W4387130504 cites W2952409962 @default.
- W4387130504 cites W2952669138 @default.
- W4387130504 cites W2969216989 @default.
- W4387130504 cites W2979546684 @default.
- W4387130504 cites W3203113665 @default.
- W4387130504 cites W4229440161 @default.
- W4387130504 cites W4231350070 @default.
- W4387130504 cites W4245281456 @default.
- W4387130504 cites W4281702314 @default.
- W4387130504 doi "https://doi.org/10.1038/s41556-023-01238-1" @default.
- W4387130504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37770566" @default.
- W4387130504 hasPublicationYear "2023" @default.
- W4387130504 type Work @default.
- W4387130504 citedByCount "0" @default.
- W4387130504 crossrefType "journal-article" @default.
- W4387130504 hasAuthorship W4387130504A5014172825 @default.
- W4387130504 hasAuthorship W4387130504A5034999320 @default.
- W4387130504 hasAuthorship W4387130504A5035339773 @default.
- W4387130504 hasAuthorship W4387130504A5037547547 @default.
- W4387130504 hasAuthorship W4387130504A5043184378 @default.
- W4387130504 hasAuthorship W4387130504A5047221605 @default.
- W4387130504 hasAuthorship W4387130504A5048840728 @default.
- W4387130504 hasAuthorship W4387130504A5049692788 @default.
- W4387130504 hasAuthorship W4387130504A5076699095 @default.
- W4387130504 hasAuthorship W4387130504A5089758283 @default.
- W4387130504 hasBestOaLocation W43871305041 @default.
- W4387130504 hasConcept C106487976 @default.
- W4387130504 hasConcept C116581196 @default.
- W4387130504 hasConcept C125705527 @default.
- W4387130504 hasConcept C142669718 @default.
- W4387130504 hasConcept C1491633281 @default.
- W4387130504 hasConcept C151166631 @default.
- W4387130504 hasConcept C178790620 @default.
- W4387130504 hasConcept C185592680 @default.
- W4387130504 hasConcept C189165786 @default.
- W4387130504 hasConcept C195065555 @default.
- W4387130504 hasConcept C195687474 @default.
- W4387130504 hasConcept C2524010 @default.
- W4387130504 hasConcept C2993400109 @default.
- W4387130504 hasConcept C33923547 @default.
- W4387130504 hasConcept C43617362 @default.
- W4387130504 hasConcept C55493867 @default.
- W4387130504 hasConcept C62478195 @default.
- W4387130504 hasConcept C84416704 @default.
- W4387130504 hasConcept C86803240 @default.