Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387130648> ?p ?o ?g. }
- W4387130648 abstract "Abstract To understand how the nucleosome remodeling and deacetylase (NuRD) complex regulates enhancers and enhancer–promoter interactions, we have developed an approach to segment and extract key biophysical parameters from live-cell three-dimensional single-molecule trajectories. Unexpectedly, this has revealed that NuRD binds to chromatin for minutes, decompacts chromatin structure and increases enhancer dynamics. We also uncovered a rare fast-diffusing state of enhancers and found that NuRD restricts the time spent in this state. Hi-C and Cut&Run experiments revealed that NuRD modulates enhancer–promoter interactions in active chromatin, allowing them to contact each other over longer distances. Furthermore, NuRD leads to a marked redistribution of CTCF and, in particular, cohesin. We propose that NuRD promotes a decondensed chromatin environment, where enhancers and promoters can contact each other over longer distances, and where the resetting of enhancer–promoter interactions brought about by the fast decondensed chromatin motions is reduced, leading to more stable, long-lived enhancer–promoter relationships." @default.
- W4387130648 created "2023-09-29" @default.
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- W4387130648 date "2023-09-28" @default.
- W4387130648 modified "2023-10-09" @default.
- W4387130648 title "Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD" @default.
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