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- W4387130654 abstract "Abstract Esophageal adenocarcinoma (EAC) is one of the deadliest tumor entities worldwide, with a 5-year survival rate of less than 25%. Unlike other tumor entities, personalized therapy options are rare, partly due to the lack of knowledge about specific subgroups. In this publication, we demonstrate a subgroup of patients with EAC in a large screening cohort of 826 patients, characterized by specific morphological and immunohistochemical features. This subgroup represents approximately 0.7% (6/826) of the total cohort. Morphological features of this subgroup show a striking clear cytoplasm of the tumour cells and the parallel existence of rare growth patterns like yolk sac-like differentiation and enteroblastic differentiation. Immunohistochemistry reveals expression of the fetal gut cell-like proteins Sal-like protein 4 (SALL4), claudin-6, and glypican 3. Interestingly, we find a correlation with alterations of SWI/SNF-complex associated genes, which are supposed to serve as tumor suppressor genes in various tumour entities. Our results suggest a possible implication of rare tumour subtypes in the WHO classification for EACs according to the classification for gastric cancer. Furthermore, claudin-6 positive tumors show promising efficacy of CAR T cell therapies in clinical studies. This represents a personalized therapeutic option for this tumor subtype." @default.
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- W4387130654 date "2023-09-28" @default.
- W4387130654 modified "2023-10-18" @default.
- W4387130654 title "Fetal gut cell-like differentiation in esophageal adenocarcinoma - rare tumor subtype with therapeutically relevant claudin-6 positivity and SWI/SNF gene alteration" @default.
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- W4387130654 doi "https://doi.org/10.21203/rs.3.rs-3356259/v1" @default.
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