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- W4387130678 abstract "Abstract Using a magnetic resonance imaging (MRI) contrast agent, MRI has made substantial contributions to glioma diagnosis. Despite that metal-free MRI agents, such as the nano free radical nitric oxide (NO•), can overcome the toxicity associated with metal-based agents in certain patient populations, however, a low spatial resolution in MRI limits their clinical development. In this study, we pretreated platelets (PLTs) and loaded them with nano NO• particles to synthesize NO•@PLT, which can overcome the low contrast and poor in vivo stability of nitroxide-based MRI contrast agents. The PLTs can serve as potential drug carriers for targeting and delivering nano NO• to gliomas and thus increase the contrast in T1-weighted imaging (T1WI) of MRI. This drug carrier system uses the unique tumor-targeting ability of PLTs and takes advantage of the high signal presentation of steady nano-NO• in T1WI, thereby ultimately achieving signal amplification of glioma in T1WI. Because of its unique ability to target PLT surface proteins, NO•@PLT has per-nitroxide transverse relativities of approximately 2-fold greater than those of free NO•, exceptional stability in highly reducing environments, and low toxicity. These features allow a sufficient NO•@PLT concentration to accumulate in murine subcutaneous glioma tumors up from 5 min to 2.5 h (optimum at 1.5 h) after systemic administration. This results in MRI contrast comparable to that of metal-based agents. This study established a promising metal-free MRI contrast agent, NO•@PLT, for glioma diagnosis, because it has superior spatial resolution owing to its high glioma-targeting ability and has significant translational implications in the clinic." @default.
- W4387130678 created "2023-09-29" @default.
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- W4387130678 date "2023-09-28" @default.
- W4387130678 modified "2023-10-18" @default.
- W4387130678 title "Platelets as Delivery Vehicles for Targeted Enrichment of NO• to Cerebral Glioma for Magnetic Resonance Imaging" @default.
- W4387130678 doi "https://doi.org/10.21203/rs.3.rs-3376622/v1" @default.
- W4387130678 hasPublicationYear "2023" @default.
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