Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387131091> ?p ?o ?g. }
- W4387131091 abstract "Formal thought disorder (FTD) is a key clinical factor in schizophrenia, but the neurobiological underpinnings remain unclear. In particular, relationship between FTD symptom dimensions and patterns of regional brain volume deficiencies in schizophrenia remain to be established in large cohorts. Even less is known about the cellular basis of FTD. Our study addresses these major obstacles based on a large multi-site cohort through the ENIGMA Schizophrenia Working Group (752 individuals with schizophrenia and 1256 controls), to unravel the neuroanatomy of positive, negative and total FTD in schizophrenia and their cellular bases. We used virtual histology tools to relate brain structural changes associated with FTD to cellular distributions in cortical regions. We identified distinct neural networks for positive and negative FTD. Both networks encompassed fronto-occipito-amygdalar brain regions, but negative FTD showed a relative sparing of orbitofrontal cortical thickness, while positive FTD also affected lateral temporal cortices. Virtual histology identified distinct transcriptomic fingerprints associated for both symptom dimensions. Negative FTD was linked to neuronal and astrocyte fingerprints, while positive FTD was also linked to microglial cell types. These findings relate different dimensions of FTD to distinct brain structural changes and their cellular underpinnings, improve our mechanistic understanding of these key psychotic symptoms." @default.
- W4387131091 created "2023-09-29" @default.
- W4387131091 creator A5000599118 @default.
- W4387131091 creator A5007448357 @default.
- W4387131091 creator A5008213547 @default.
- W4387131091 creator A5010017762 @default.
- W4387131091 creator A5010486628 @default.
- W4387131091 creator A5011836054 @default.
- W4387131091 creator A5011966818 @default.
- W4387131091 creator A5013850648 @default.
- W4387131091 creator A5014561886 @default.
- W4387131091 creator A5020991260 @default.
- W4387131091 creator A5025392131 @default.
- W4387131091 creator A5027253477 @default.
- W4387131091 creator A5028421369 @default.
- W4387131091 creator A5029787846 @default.
- W4387131091 creator A5031284141 @default.
- W4387131091 creator A5032107528 @default.
- W4387131091 creator A5032850756 @default.
- W4387131091 creator A5033526894 @default.
- W4387131091 creator A5035899146 @default.
- W4387131091 creator A5039986534 @default.
- W4387131091 creator A5045381374 @default.
- W4387131091 creator A5046050779 @default.
- W4387131091 creator A5047545028 @default.
- W4387131091 creator A5050354298 @default.
- W4387131091 creator A5059704237 @default.
- W4387131091 creator A5063092296 @default.
- W4387131091 creator A5066509392 @default.
- W4387131091 creator A5066997429 @default.
- W4387131091 creator A5067261122 @default.
- W4387131091 creator A5067269418 @default.
- W4387131091 creator A5068935286 @default.
- W4387131091 creator A5072555008 @default.
- W4387131091 creator A5078783945 @default.
- W4387131091 creator A5078810947 @default.
- W4387131091 creator A5081594966 @default.
- W4387131091 creator A5084292760 @default.
- W4387131091 creator A5086121026 @default.
- W4387131091 creator A5087017146 @default.
- W4387131091 creator A5089583295 @default.
- W4387131091 creator A5091780356 @default.
- W4387131091 date "2023-09-28" @default.
- W4387131091 modified "2023-10-17" @default.
- W4387131091 title "Neural Correlates of Positive and Negative Formal Thought Disorder in Individuals with Schizophrenia: An ENIGMA Schizophrenia Working Group Study" @default.
- W4387131091 cites W1733003206 @default.
- W4387131091 cites W1955123844 @default.
- W4387131091 cites W1983565062 @default.
- W4387131091 cites W1996642120 @default.
- W4387131091 cites W1997950587 @default.
- W4387131091 cites W2004043218 @default.
- W4387131091 cites W2008020964 @default.
- W4387131091 cites W2022912129 @default.
- W4387131091 cites W2026020643 @default.
- W4387131091 cites W2032353602 @default.
- W4387131091 cites W2033617297 @default.
- W4387131091 cites W2034519697 @default.
- W4387131091 cites W2053725214 @default.
- W4387131091 cites W2055655674 @default.
- W4387131091 cites W2061557732 @default.
- W4387131091 cites W2066794669 @default.
- W4387131091 cites W2072459792 @default.
- W4387131091 cites W2072486526 @default.
- W4387131091 cites W2072751116 @default.
- W4387131091 cites W2083540742 @default.
- W4387131091 cites W2101135654 @default.
- W4387131091 cites W2125652023 @default.
- W4387131091 cites W2127962453 @default.
- W4387131091 cites W2133916600 @default.
- W4387131091 cites W2134888862 @default.
- W4387131091 cites W2140327288 @default.
- W4387131091 cites W2145784877 @default.
- W4387131091 cites W2150258126 @default.
- W4387131091 cites W2153224757 @default.
- W4387131091 cites W2165302236 @default.
- W4387131091 cites W2165769276 @default.
- W4387131091 cites W2192825006 @default.
- W4387131091 cites W2194300589 @default.
- W4387131091 cites W2213127880 @default.
- W4387131091 cites W2255138985 @default.
- W4387131091 cites W2320238569 @default.
- W4387131091 cites W2430823800 @default.
- W4387131091 cites W2435470896 @default.
- W4387131091 cites W2513722234 @default.
- W4387131091 cites W2519022394 @default.
- W4387131091 cites W2570802757 @default.
- W4387131091 cites W2597414123 @default.
- W4387131091 cites W2602841893 @default.
- W4387131091 cites W2617903284 @default.
- W4387131091 cites W2725078927 @default.
- W4387131091 cites W2742494644 @default.
- W4387131091 cites W2802065111 @default.
- W4387131091 cites W2806131091 @default.
- W4387131091 cites W2809142429 @default.
- W4387131091 cites W2911701742 @default.
- W4387131091 cites W2951670472 @default.
- W4387131091 cites W2969219450 @default.
- W4387131091 cites W2976010611 @default.
- W4387131091 cites W2980332267 @default.
- W4387131091 cites W2984627042 @default.