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- W4387132672 endingPage "4771" @default.
- W4387132672 startingPage "4771" @default.
- W4387132672 abstract "Breast cancer (BC) is the most common cancer type in women and the second leading cause of death. Despite recent advances, the mortality rate of BC is still high, highlighting a need to develop new treatment strategies including the modulation of the immune system and immunotherapies. In this regard, understanding the complex function of the involved immune cells and their crosstalk with tumor cells is of great importance. T-cells are recognized as the most important cells in the tumor microenvironment and are divided into several subtypes including helper, cytotoxic, and regulatory T-cells according to their transcription factors, markers, and functions. This article attempts to provide a comprehensive review of the role of T-cell subsets in the prognosis and treatment of patients with BC, and crosstalk between tumor cells and T-cells. The literature overwhelmingly contains controversial findings mainly due to the plasticity of T-cell subsets within the inflammatory conditions and the use of different panels for their phenotyping. However, investigating the role of T-cells in BC immunity depends on a variety of factors including tumor types or subtypes, the stage of the disease, the localization of the cells in the tumor tissue and the presence of different cells or cytokines." @default.
- W4387132672 created "2023-09-29" @default.
- W4387132672 creator A5013236139 @default.
- W4387132672 creator A5055398153 @default.
- W4387132672 creator A5083736793 @default.
- W4387132672 creator A5084847662 @default.
- W4387132672 creator A5092960288 @default.
- W4387132672 date "2023-09-28" @default.
- W4387132672 modified "2023-10-17" @default.
- W4387132672 title "Dual Functions of T Lymphocytes in Breast Carcinoma: From Immune Protection to Orchestrating Tumor Progression and Metastasis" @default.
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