Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387134079> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4387134079 abstract "Abstract Background: In the modern surgical and chemotherapy era metastatic liver disease is in the renaissance, enabling to extend patient's life with metastatic liver disease. However, the primary limiting factor to more radical surgical treatment is liver volume, particularly in patients with chemotherapy-induced liver damage. Since results regarding whether chemotherapy has an impact on liver volume regeneration are ambiguous, we have aimed to analyze liver regeneration and the factors influencing it. Methods: A prospective cohort study was performed. Patient inclusion criteria were as follows: patients between 18 and 90 years; liver resection of at least 2 segments either for benign or colorectal cancer metastasis; patients who underwent liver resection due to metastatic disease had to have previous chemotherapy treatment. All patients were divided into 2 groups – control and chemotherapy groups. Analysis of demographics, perioperative data, liver enzymes, liver stiffness, and liver volume was carried out, as well as the impact on regeneration marker expression in serum and liver tissue. Results: 34 patients in all were involved in this trial, and they were split into two groups: chemotherapy and control. The two groups were similar. Except for comorbidities, there were no variations between the perioperative and demographic data. In the chemotherapy group, regenerated liver volume was lower compared to control, 1240.5±69.6 vs 1525.3±106.6 ml p-0.039. Further analysis revealed that the chemotherapy group had increased anti-regenerative TGF β1 expression compared to control in serum and liver tissue, p-0.02 and p-0.034. Conclusions: The present study showed that chemotherapy is associated with lower regenerated volume in patients who received resection. Anti-regenerative TGFβ1 marker expression in liver tissue and serum might have an impact on regenerated liver volume, however, the exact mechanisms involved in decreased regeneration are further to be studied." @default.
- W4387134079 created "2023-09-29" @default.
- W4387134079 creator A5007729144 @default.
- W4387134079 creator A5023561003 @default.
- W4387134079 creator A5058203805 @default.
- W4387134079 creator A5071335046 @default.
- W4387134079 creator A5082267106 @default.
- W4387134079 creator A5084239911 @default.
- W4387134079 creator A5088230342 @default.
- W4387134079 date "2023-09-28" @default.
- W4387134079 modified "2023-10-18" @default.
- W4387134079 title "TGF β1 negatively impacts liver regeneration under chemotherapy" @default.
- W4387134079 cites W2004016630 @default.
- W4387134079 cites W2122750846 @default.
- W4387134079 cites W2123555377 @default.
- W4387134079 cites W2131745440 @default.
- W4387134079 cites W2164360023 @default.
- W4387134079 cites W2467834689 @default.
- W4387134079 cites W2470575266 @default.
- W4387134079 cites W2789425692 @default.
- W4387134079 cites W2917891037 @default.
- W4387134079 cites W2947469810 @default.
- W4387134079 cites W4313530567 @default.
- W4387134079 cites W4385774018 @default.
- W4387134079 doi "https://doi.org/10.21203/rs.3.rs-3369527/v1" @default.
- W4387134079 hasPublicationYear "2023" @default.
- W4387134079 type Work @default.
- W4387134079 citedByCount "0" @default.
- W4387134079 crossrefType "posted-content" @default.
- W4387134079 hasAuthorship W4387134079A5007729144 @default.
- W4387134079 hasAuthorship W4387134079A5023561003 @default.
- W4387134079 hasAuthorship W4387134079A5058203805 @default.
- W4387134079 hasAuthorship W4387134079A5071335046 @default.
- W4387134079 hasAuthorship W4387134079A5082267106 @default.
- W4387134079 hasAuthorship W4387134079A5084239911 @default.
- W4387134079 hasAuthorship W4387134079A5088230342 @default.
- W4387134079 hasBestOaLocation W43871340791 @default.
- W4387134079 hasConcept C121608353 @default.
- W4387134079 hasConcept C126322002 @default.
- W4387134079 hasConcept C141071460 @default.
- W4387134079 hasConcept C142724271 @default.
- W4387134079 hasConcept C143998085 @default.
- W4387134079 hasConcept C171056886 @default.
- W4387134079 hasConcept C2776231280 @default.
- W4387134079 hasConcept C2776694085 @default.
- W4387134079 hasConcept C2776795407 @default.
- W4387134079 hasConcept C2777075537 @default.
- W4387134079 hasConcept C2779013556 @default.
- W4387134079 hasConcept C31174226 @default.
- W4387134079 hasConcept C71924100 @default.
- W4387134079 hasConcept C86803240 @default.
- W4387134079 hasConcept C90924648 @default.
- W4387134079 hasConcept C95444343 @default.
- W4387134079 hasConceptScore W4387134079C121608353 @default.
- W4387134079 hasConceptScore W4387134079C126322002 @default.
- W4387134079 hasConceptScore W4387134079C141071460 @default.
- W4387134079 hasConceptScore W4387134079C142724271 @default.
- W4387134079 hasConceptScore W4387134079C143998085 @default.
- W4387134079 hasConceptScore W4387134079C171056886 @default.
- W4387134079 hasConceptScore W4387134079C2776231280 @default.
- W4387134079 hasConceptScore W4387134079C2776694085 @default.
- W4387134079 hasConceptScore W4387134079C2776795407 @default.
- W4387134079 hasConceptScore W4387134079C2777075537 @default.
- W4387134079 hasConceptScore W4387134079C2779013556 @default.
- W4387134079 hasConceptScore W4387134079C31174226 @default.
- W4387134079 hasConceptScore W4387134079C71924100 @default.
- W4387134079 hasConceptScore W4387134079C86803240 @default.
- W4387134079 hasConceptScore W4387134079C90924648 @default.
- W4387134079 hasConceptScore W4387134079C95444343 @default.
- W4387134079 hasLocation W43871340791 @default.
- W4387134079 hasOpenAccess W4387134079 @default.
- W4387134079 hasPrimaryLocation W43871340791 @default.
- W4387134079 hasRelatedWork W2126209504 @default.
- W4387134079 hasRelatedWork W2354785620 @default.
- W4387134079 hasRelatedWork W2509733117 @default.
- W4387134079 hasRelatedWork W2586998360 @default.
- W4387134079 hasRelatedWork W2616818175 @default.
- W4387134079 hasRelatedWork W2803916346 @default.
- W4387134079 hasRelatedWork W4200116281 @default.
- W4387134079 hasRelatedWork W4285267799 @default.
- W4387134079 hasRelatedWork W4322008219 @default.
- W4387134079 hasRelatedWork W4377011081 @default.
- W4387134079 isParatext "false" @default.
- W4387134079 isRetracted "false" @default.
- W4387134079 workType "article" @default.