Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387134611> ?p ?o ?g. }
- W4387134611 abstract "Colorectal cancer (CRC) remains a leading cause of cancer-related mortality despite efforts to improve standard interventions. As CRC patients can benefit from immunotherapeutic strategies that incite effector T cell action, cancer vaccines represent a safe and promising therapeutic approach to elicit protective and durable immune responses against components of the tumor microenvironment (TME). In this study, we investigate the pre-clinical potential of a Listeria monocytogenes (Lm)-based vaccine targeting the CRC-associated vasculature. CRC survival and progression are reliant on functioning blood vessels to effectively mediate various metabolic processes and oxygenate underlying tissues. We, therefore, advance the strategy of initiating immunity in syngeneic mouse models against the endogenous pericyte antigen RGS5, which is a critical mediator of pathological vascularization. Overall, Lm-based vaccination safely induced potent anti-tumor effects that consisted of recruiting functional Type-1-associated T cells into the TME and reducing tumor blood vessel content. This study underscores the promising clinical potential of targeting RGS5 against vascularized tumors like CRC." @default.
- W4387134611 created "2023-09-29" @default.
- W4387134611 creator A5011838979 @default.
- W4387134611 creator A5037986650 @default.
- W4387134611 creator A5050022897 @default.
- W4387134611 creator A5059741475 @default.
- W4387134611 creator A5073700210 @default.
- W4387134611 creator A5074188497 @default.
- W4387134611 creator A5082742753 @default.
- W4387134611 creator A5086312125 @default.
- W4387134611 creator A5086826588 @default.
- W4387134611 date "2023-09-28" @default.
- W4387134611 modified "2023-10-16" @default.
- W4387134611 title "Listeria-based vaccination against the pericyte antigen RGS5 elicits anti-vascular effects and colon cancer protection" @default.
- W4387134611 cites W1663434518 @default.
- W4387134611 cites W1812721298 @default.
- W4387134611 cites W1831720205 @default.
- W4387134611 cites W1964435516 @default.
- W4387134611 cites W1969047155 @default.
- W4387134611 cites W1989623935 @default.
- W4387134611 cites W1990900131 @default.
- W4387134611 cites W1992512667 @default.
- W4387134611 cites W2006455113 @default.
- W4387134611 cites W2010656074 @default.
- W4387134611 cites W2047928035 @default.
- W4387134611 cites W2056330259 @default.
- W4387134611 cites W2064873017 @default.
- W4387134611 cites W2068386288 @default.
- W4387134611 cites W2070636596 @default.
- W4387134611 cites W2071867975 @default.
- W4387134611 cites W2097350641 @default.
- W4387134611 cites W2098267542 @default.
- W4387134611 cites W2104300873 @default.
- W4387134611 cites W2107069541 @default.
- W4387134611 cites W2107277218 @default.
- W4387134611 cites W2118321576 @default.
- W4387134611 cites W2125732073 @default.
- W4387134611 cites W2128447158 @default.
- W4387134611 cites W2129125548 @default.
- W4387134611 cites W2147650814 @default.
- W4387134611 cites W2150462175 @default.
- W4387134611 cites W2156092970 @default.
- W4387134611 cites W2165465840 @default.
- W4387134611 cites W2192080449 @default.
- W4387134611 cites W2271914738 @default.
- W4387134611 cites W2328107850 @default.
- W4387134611 cites W2328995829 @default.
- W4387134611 cites W2511635014 @default.
- W4387134611 cites W2590023130 @default.
- W4387134611 cites W2601414401 @default.
- W4387134611 cites W2727837936 @default.
- W4387134611 cites W2749319028 @default.
- W4387134611 cites W2750364489 @default.
- W4387134611 cites W2775859354 @default.
- W4387134611 cites W2786753426 @default.
- W4387134611 cites W2891141728 @default.
- W4387134611 cites W2899862051 @default.
- W4387134611 cites W2914098003 @default.
- W4387134611 cites W2920863623 @default.
- W4387134611 cites W2954200881 @default.
- W4387134611 cites W2963723040 @default.
- W4387134611 cites W2964300303 @default.
- W4387134611 cites W2994118818 @default.
- W4387134611 cites W3015834769 @default.
- W4387134611 cites W3128646645 @default.
- W4387134611 cites W3154458396 @default.
- W4387134611 cites W3178723556 @default.
- W4387134611 cites W3196885036 @default.
- W4387134611 cites W3213755833 @default.
- W4387134611 cites W4200368048 @default.
- W4387134611 cites W4289517136 @default.
- W4387134611 cites W4308803453 @default.
- W4387134611 cites W4309215150 @default.
- W4387134611 cites W4313335565 @default.
- W4387134611 cites W4321372237 @default.
- W4387134611 cites W4324020788 @default.
- W4387134611 cites W4380049961 @default.
- W4387134611 cites W4381715982 @default.
- W4387134611 doi "https://doi.org/10.1080/2162402x.2023.2260620" @default.
- W4387134611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37781234" @default.
- W4387134611 hasPublicationYear "2023" @default.
- W4387134611 type Work @default.
- W4387134611 citedByCount "0" @default.
- W4387134611 crossrefType "journal-article" @default.
- W4387134611 hasAuthorship W4387134611A5011838979 @default.
- W4387134611 hasAuthorship W4387134611A5037986650 @default.
- W4387134611 hasAuthorship W4387134611A5050022897 @default.
- W4387134611 hasAuthorship W4387134611A5059741475 @default.
- W4387134611 hasAuthorship W4387134611A5073700210 @default.
- W4387134611 hasAuthorship W4387134611A5074188497 @default.
- W4387134611 hasAuthorship W4387134611A5082742753 @default.
- W4387134611 hasAuthorship W4387134611A5086312125 @default.
- W4387134611 hasAuthorship W4387134611A5086826588 @default.
- W4387134611 hasBestOaLocation W43871346111 @default.
- W4387134611 hasConcept C121608353 @default.
- W4387134611 hasConcept C123012128 @default.
- W4387134611 hasConcept C126322002 @default.
- W4387134611 hasConcept C147483822 @default.
- W4387134611 hasConcept C202751555 @default.
- W4387134611 hasConcept C203014093 @default.