Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387135079> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4387135079 abstract "<h3>Introduction/Background</h3> To analyze the relationship of 18F-FDG-PET/CT biomarkers and clinical, surgical and pathological variables with the response to neoadjuvant chemotherapy(NACT) in startup inoperable patients (FIGO III/IV) high-grade serous ovarian cancer(HGSC). <h3>Methodology</h3> Retrospective review of HGSC patients who underwent 18F-FDG-PET/CT before(PETpre) and after NACT(PETpost). NACT response was assessed by CA-125 levels, pathological chemotherapy response score(CRS 3-complete vs CRS1&2-partial and no response), and cytoreduction(R0-complete vs. R1-incomplete). 18F-FDG-PET/CT parameters were obtained by means of the segmentation of the supra and infradiaphragmatic disease using Syngo.via, with automatic thresholding at 30% of SUVmax. Metabolic parameters studied: metabolic active tumor volume(MTV) and total lesion glycolysis(TLG). The values for all these parameters at PETpre, as well as the presence of ascites with pathological 18F-FDG uptake(SUVmax ascites >SUVmean blood pool) and the modeled CA-125 elimination rate constant(KELIM, favourable if ≥ 1) were assessed in relation to NACT response. Variables were described by mean(SD) or median(IQR). Paired relationship among variables was assessed by McNemar and Wilcoxon test. <h3>Results</h3> Seventeen patients were included, mean age of 63.6 years(range: 37–78); all patients displayed CA-125>35 and 76.5% showed pathological uptake in ascites in PETpre. After NACT(94.1% of patients received three cycles), values of CA-125<35 were observed in 35.3%, all patients normalized pathological uptake in ascites in PETpost and metabolic parameters studied decreased very significantly after NACT. Almost half patients(47.1%) presented complete CRS and 88.2% complete cytoreduction(R0); KELIM was favourable in 42.9%. Despite these changes, only reduction of CA-125 was moderately correlated to reduction of some metabolic parameters: total TLG(rho:0.535; p=0,027), total infradiaphragmatic disease MTV(rho:0.577; p=0,015) and TLG(rho:0.597; p=0,011), and total peritoneal disease MTV(rho:0.609; p=0,012) and TLG(rho:0.609; p=0,014). Studied variables did not relate to cytoreduction and CRS. <h3>Conclusion</h3> NACT in HGSC patients with FIGO III-IV is related to big changes in most variables studied. Nevertheless, relationships to CRS and cytoreduction were impaired by the small sample size. <h3>Disclosures</h3> Nothing to disclose." @default.
- W4387135079 created "2023-09-29" @default.
- W4387135079 creator A5000528405 @default.
- W4387135079 creator A5009823951 @default.
- W4387135079 creator A5013580487 @default.
- W4387135079 creator A5018520874 @default.
- W4387135079 creator A5021487857 @default.
- W4387135079 creator A5035502806 @default.
- W4387135079 creator A5057959074 @default.
- W4387135079 creator A5059634794 @default.
- W4387135079 creator A5061258630 @default.
- W4387135079 creator A5062035800 @default.
- W4387135079 creator A5083896363 @default.
- W4387135079 date "2023-09-01" @default.
- W4387135079 modified "2023-10-18" @default.
- W4387135079 title "#846 Relationship of 18F-FDG PET/CT biomarkers and clinical, surgical and pathological variables with the response to neoadjuvant chemotherapy in startup inoperable high-grade serous ovarian cancer patients" @default.
- W4387135079 doi "https://doi.org/10.1136/ijgc-2023-esgo.659" @default.
- W4387135079 hasPublicationYear "2023" @default.
- W4387135079 type Work @default.
- W4387135079 citedByCount "0" @default.
- W4387135079 crossrefType "proceedings-article" @default.
- W4387135079 hasAuthorship W4387135079A5000528405 @default.
- W4387135079 hasAuthorship W4387135079A5009823951 @default.
- W4387135079 hasAuthorship W4387135079A5013580487 @default.
- W4387135079 hasAuthorship W4387135079A5018520874 @default.
- W4387135079 hasAuthorship W4387135079A5021487857 @default.
- W4387135079 hasAuthorship W4387135079A5035502806 @default.
- W4387135079 hasAuthorship W4387135079A5057959074 @default.
- W4387135079 hasAuthorship W4387135079A5059634794 @default.
- W4387135079 hasAuthorship W4387135079A5061258630 @default.
- W4387135079 hasAuthorship W4387135079A5062035800 @default.
- W4387135079 hasAuthorship W4387135079A5083896363 @default.
- W4387135079 hasBestOaLocation W43871350791 @default.
- W4387135079 hasConcept C121608353 @default.
- W4387135079 hasConcept C126322002 @default.
- W4387135079 hasConcept C126838900 @default.
- W4387135079 hasConcept C146357865 @default.
- W4387135079 hasConcept C150173356 @default.
- W4387135079 hasConcept C151730666 @default.
- W4387135079 hasConcept C207886595 @default.
- W4387135079 hasConcept C2776694085 @default.
- W4387135079 hasConcept C2778239845 @default.
- W4387135079 hasConcept C2780427987 @default.
- W4387135079 hasConcept C2780496750 @default.
- W4387135079 hasConcept C2781451048 @default.
- W4387135079 hasConcept C2989005 @default.
- W4387135079 hasConcept C71924100 @default.
- W4387135079 hasConcept C86803240 @default.
- W4387135079 hasConceptScore W4387135079C121608353 @default.
- W4387135079 hasConceptScore W4387135079C126322002 @default.
- W4387135079 hasConceptScore W4387135079C126838900 @default.
- W4387135079 hasConceptScore W4387135079C146357865 @default.
- W4387135079 hasConceptScore W4387135079C150173356 @default.
- W4387135079 hasConceptScore W4387135079C151730666 @default.
- W4387135079 hasConceptScore W4387135079C207886595 @default.
- W4387135079 hasConceptScore W4387135079C2776694085 @default.
- W4387135079 hasConceptScore W4387135079C2778239845 @default.
- W4387135079 hasConceptScore W4387135079C2780427987 @default.
- W4387135079 hasConceptScore W4387135079C2780496750 @default.
- W4387135079 hasConceptScore W4387135079C2781451048 @default.
- W4387135079 hasConceptScore W4387135079C2989005 @default.
- W4387135079 hasConceptScore W4387135079C71924100 @default.
- W4387135079 hasConceptScore W4387135079C86803240 @default.
- W4387135079 hasLocation W43871350791 @default.
- W4387135079 hasOpenAccess W4387135079 @default.
- W4387135079 hasPrimaryLocation W43871350791 @default.
- W4387135079 hasRelatedWork W2040705087 @default.
- W4387135079 hasRelatedWork W2311734504 @default.
- W4387135079 hasRelatedWork W2350656827 @default.
- W4387135079 hasRelatedWork W2389541661 @default.
- W4387135079 hasRelatedWork W2406404783 @default.
- W4387135079 hasRelatedWork W3010986187 @default.
- W4387135079 hasRelatedWork W3032219018 @default.
- W4387135079 hasRelatedWork W3175992975 @default.
- W4387135079 hasRelatedWork W4214690187 @default.
- W4387135079 hasRelatedWork W3217402566 @default.
- W4387135079 isParatext "false" @default.
- W4387135079 isRetracted "false" @default.
- W4387135079 workType "article" @default.