FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387135221> ?p ?o ?g. }

• W4387135221 endingPage "3918" @default.
• W4387135221 startingPage "3918" @default.
• W4387135221 abstract "Large bone defects are clinically challenging, with up to 15% of these requiring surgical intervention due to non-union. Bone grafts (autographs or allografts) can be used but they have many limitations, meaning that polymer-based bone tissue engineered scaffolds (tissue engineering) are a more promising solution. Clinical translation of scaffolds is still limited but this could be improved by exploring the whole design space using virtual tools such as mechanobiological modeling. In tissue engineering, a significant research effort has been expended on materials and manufacturing but relatively little has been focused on shape. Most scaffolds use regular pore architecture throughout, leaving custom or irregular pore architecture designs unexplored. The aim of this paper is to introduce a virtual design environment for scaffold development and to illustrate its potential by exploring the relationship of pore architecture to bone tissue formation. A virtual design framework has been created utilizing a mechanical stress finite element (FE) model coupled with a cell behavior agent-based model to investigate the mechanobiological relationships of scaffold shape and bone tissue formation. A case study showed that modifying pore architecture from regular to irregular enabled between 17 and 33% more bone formation within the 4-16-week time periods analyzed. This work shows that shape, specifically pore architecture, is as important as other design parameters such as material and manufacturing for improving the function of bone tissue scaffold implants. It is recommended that future research be conducted to both optimize irregular pore architectures and to explore the potential extension of the concept of shape modification beyond mechanical stress to look at other factors present in the body." @default.
• W4387135221 created "2023-09-29" @default.
• W4387135221 creator A5013445198 @default.
• W4387135221 creator A5034065512 @default.
• W4387135221 creator A5078439513 @default.
• W4387135221 creator A5085144376 @default.
• W4387135221 date "2023-09-28" @default.
• W4387135221 modified "2023-10-18" @default.
• W4387135221 title "Virtual Design of 3D-Printed Bone Tissue Engineered Scaffold Shape Using Mechanobiological Modeling: Relationship of Scaffold Pore Architecture to Bone Tissue Formation" @default.
• W4387135221 cites W1480435855 @default.
• W4387135221 cites W1928785183 @default.
• W4387135221 cites W1964733232 @default.
• W4387135221 cites W1968822620 @default.
• W4387135221 cites W1969033706 @default.
• W4387135221 cites W1974529142 @default.
• W4387135221 cites W1974629710 @default.
• W4387135221 cites W1981701289 @default.
• W4387135221 cites W1989992560 @default.
• W4387135221 cites W1991396333 @default.
• W4387135221 cites W1995022241 @default.
• W4387135221 cites W1999985601 @default.
• W4387135221 cites W2001558471 @default.
• W4387135221 cites W2001668657 @default.
• W4387135221 cites W2006424844 @default.
• W4387135221 cites W2007567936 @default.
• W4387135221 cites W2014035897 @default.
• W4387135221 cites W2015701478 @default.
• W4387135221 cites W2022302468 @default.
• W4387135221 cites W2024332956 @default.
• W4387135221 cites W2025400320 @default.
• W4387135221 cites W2039088504 @default.
• W4387135221 cites W2039480155 @default.
• W4387135221 cites W2039538032 @default.
• W4387135221 cites W2052441415 @default.
• W4387135221 cites W2056833999 @default.
• W4387135221 cites W2062278482 @default.
• W4387135221 cites W2062510478 @default.
• W4387135221 cites W2063973396 @default.
• W4387135221 cites W2067263729 @default.
• W4387135221 cites W2068038765 @default.
• W4387135221 cites W2082544243 @default.
• W4387135221 cites W2087304140 @default.
• W4387135221 cites W2092056186 @default.
• W4387135221 cites W2109657122 @default.
• W4387135221 cites W2111312751 @default.
• W4387135221 cites W2120761640 @default.
• W4387135221 cites W2121681341 @default.
• W4387135221 cites W2137612350 @default.
• W4387135221 cites W2151910255 @default.
• W4387135221 cites W2153427256 @default.
• W4387135221 cites W2162281037 @default.
• W4387135221 cites W2168016879 @default.
• W4387135221 cites W2169884717 @default.
• W4387135221 cites W2230487954 @default.
• W4387135221 cites W2322845683 @default.
• W4387135221 cites W2342145097 @default.
• W4387135221 cites W2403621207 @default.
• W4387135221 cites W2413702741 @default.
• W4387135221 cites W2563245491 @default.
• W4387135221 cites W2765174355 @default.
• W4387135221 cites W2782524119 @default.
• W4387135221 cites W2782580194 @default.
• W4387135221 cites W2800988732 @default.
• W4387135221 cites W2923823566 @default.
• W4387135221 cites W2964349475 @default.
• W4387135221 cites W2989884116 @default.
• W4387135221 cites W2990339659 @default.
• W4387135221 cites W3047082191 @default.
• W4387135221 cites W3048656954 @default.
• W4387135221 cites W3098646193 @default.
• W4387135221 cites W3118402918 @default.
• W4387135221 cites W3127525827 @default.
• W4387135221 cites W3135354201 @default.
• W4387135221 cites W3167546054 @default.
• W4387135221 cites W3170110444 @default.
• W4387135221 cites W3182751677 @default.
• W4387135221 cites W3203865122 @default.
• W4387135221 cites W3207134863 @default.
• W4387135221 cites W3216935981 @default.
• W4387135221 cites W4223628801 @default.
• W4387135221 cites W4226160109 @default.
• W4387135221 cites W4240225905 @default.
• W4387135221 cites W4296823090 @default.
• W4387135221 cites W4311876056 @default.
• W4387135221 cites W846454215 @default.
• W4387135221 doi "https://doi.org/10.3390/polym15193918" @default.
• W4387135221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37835968" @default.
• W4387135221 hasPublicationYear "2023" @default.
• W4387135221 type Work @default.
• W4387135221 citedByCount "0" @default.
• W4387135221 crossrefType "journal-article" @default.
• W4387135221 hasAuthorship W4387135221A5013445198 @default.
• W4387135221 hasAuthorship W4387135221A5034065512 @default.
• W4387135221 hasAuthorship W4387135221A5078439513 @default.
• W4387135221 hasAuthorship W4387135221A5085144376 @default.
• W4387135221 hasBestOaLocation W43871352211 @default.
• W4387135221 hasConcept C127413603 @default.
• W4387135221 hasConcept C136229726 @default.

• next