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• W4387135265 abstract "<h3>Introduction/Background</h3> Synchronous endometrial and ovarian carcinomas represent approximately 5% of endometrial cancers and about 10% of ovarian cancers. Distinguishing between double primaries from metastatic tumors is essential for the selection of optimal adjuvant treatment and predicting patient prognosis. <h3>Methodology</h3> We retrospectively reviewed 8 patients with pathologically confirmed synchronous endometrial and ovarian endometrioid carcinoma (SEO-EC) who underwent surgery at Clínica Universidad de Navarra between 2017 to 2023. We analyzed the molecular profile, using next generation sequencing of 8 samples, from 5 patients. We subjected endometrial and ovarian tumors from 3 patients to parallel NGS with Oncomine Comprehensive Assay. The clonal relationship between endometrial and ovarian carcinomas was assessed using the similarity index (SI). <h3>Results</h3> Complete information on molecular subtype classification was available in 5 patients. Two were mismatch repair deficient (MMR-D), 1 POLE-mutated and 2 no specific molecular profile (NSMP), respectively. The classification was not available in 3 patients as POLE mutation analysis was omitted, of which 2 had an abnormal expression of p53. During follow-up, 2 patients relapsed with 1 disease-specific death. The molecular profile of those who relapsed, 1 was NSMP and the other undetermined (NSMP vs POLE), respectively. The SI ranges between 0 (completely different) and 1 (identical genomic profiles). The 3 patients subjected to parallel NGS analysis had a SI of 0.66, 0.75 and 1, respectively. <h3>Conclusion</h3> Our data provide additional evidence to suggest that in patients with SEO-EC, these lesions are usually clonally related and probably there is only one primary tumors, The other hypothesis is the synchronic origin, not necessarily dissemination. The fact that the 3 patients subjected to parallel NGS analysis shared one or more somatic mutations support clonal origin in these cases, as determined by the SI. Nevertheless, further research and a larger sample size are needed to validate this hypothesis. <h3>Disclosures</h3> None" @default.
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• W4387135265 date "2023-09-01" @default.
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• W4387135265 title "#902 Synchronous endometrial and ovarian endometrioid carcinoma: an intricate clinical dilemma" @default.
• W4387135265 doi "https://doi.org/10.1136/ijgc-2023-esgo.388" @default.
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