Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387135324> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4387135324 abstract "<h3>Introduction/Background</h3> Ovarian cancer (OC) is considered to demonstrate multifactorial causes including multiple genetic contributors. Variants of many genes are suspected to participate in increasing the risk for OC. Some of those are genes involved in tumor microenvironment formation, an example of which is Interleukin-10 (IL-10) gene. We tried to analyze the single nucleotide polymorphism (SNP) (rs1800896) in the IL-10 gene in relationship to OC risk and correlated it with the levels of IL-10 in the peripheral blood of OC patients. <h3>Methodology</h3> A case-control study was performed on a total of 20 women, with histologically confirmed epithelial ovarian cancers and 20 age-matched controls. SNP genotyping was performed with TaqMan Assay with Real Time-PCR. Statistical analyses were performed by GraphPad Prism 9.3.1 for macOS. Statistical significance for differences in genotype frequencies was determined by Chi-square and Fisher’s exact test. <h3>Results</h3> The genotype distributions of IL-10 gene polymorphisms among cancer and control groups were all according to the expected Hardy–Weinberg equilibrium. There was no statistically significant difference in frequency of genotypes and alleles between the two study groups. In another analysis, the samples were grouped according to the polymorphic variant IL 10 (− 1082) A/G. Subjects having the homozygous variant (AA) had lower IL-10 mRNA levels than those with the homozygous wild (GG) genotype in both, ovarian cancer patients and controls, p < 0.05. mRNA levels on IL-10, IL-8 were different among cases and controls (p < 0.05). Patients with OC had higher level of mRNA for IL-10 and IL-8 than controls. <h3>Conclusion</h3> This relatively small-scaled study demonstrated, that mRNA levels of IL-10 and IL-8 are high in patients with OC and this goes along with the serum levels of proteins. However this difference is not determined by allelic differences, which means that other factors - epigenetic and regulatory - up-regulate expression of IL-10 and IL-8 genes in patients with OC. <h3>Disclosures</h3> The study was supported by Shota Rustaveli National Science Foundation (Grant N YS-21-1216)." @default.
- W4387135324 created "2023-09-29" @default.
- W4387135324 creator A5010132278 @default.
- W4387135324 creator A5010895174 @default.
- W4387135324 creator A5011436749 @default.
- W4387135324 creator A5018317353 @default.
- W4387135324 creator A5026867072 @default.
- W4387135324 creator A5058692648 @default.
- W4387135324 creator A5059404564 @default.
- W4387135324 creator A5060759655 @default.
- W4387135324 date "2023-09-01" @default.
- W4387135324 modified "2023-09-29" @default.
- W4387135324 title "#1063 IL-10 polymorphysms as ovarian cancer risk factor in georgian women" @default.
- W4387135324 doi "https://doi.org/10.1136/ijgc-2023-esgo.897" @default.
- W4387135324 hasPublicationYear "2023" @default.
- W4387135324 type Work @default.
- W4387135324 citedByCount "0" @default.
- W4387135324 crossrefType "proceedings-article" @default.
- W4387135324 hasAuthorship W4387135324A5010132278 @default.
- W4387135324 hasAuthorship W4387135324A5010895174 @default.
- W4387135324 hasAuthorship W4387135324A5011436749 @default.
- W4387135324 hasAuthorship W4387135324A5018317353 @default.
- W4387135324 hasAuthorship W4387135324A5026867072 @default.
- W4387135324 hasAuthorship W4387135324A5058692648 @default.
- W4387135324 hasAuthorship W4387135324A5059404564 @default.
- W4387135324 hasAuthorship W4387135324A5060759655 @default.
- W4387135324 hasBestOaLocation W43871353241 @default.
- W4387135324 hasConcept C104317684 @default.
- W4387135324 hasConcept C121608353 @default.
- W4387135324 hasConcept C126322002 @default.
- W4387135324 hasConcept C135763542 @default.
- W4387135324 hasConcept C139275648 @default.
- W4387135324 hasConcept C143998085 @default.
- W4387135324 hasConcept C153209595 @default.
- W4387135324 hasConcept C2780427987 @default.
- W4387135324 hasConcept C31467283 @default.
- W4387135324 hasConcept C54355233 @default.
- W4387135324 hasConcept C65409693 @default.
- W4387135324 hasConcept C71924100 @default.
- W4387135324 hasConcept C86803240 @default.
- W4387135324 hasConcept C90924648 @default.
- W4387135324 hasConceptScore W4387135324C104317684 @default.
- W4387135324 hasConceptScore W4387135324C121608353 @default.
- W4387135324 hasConceptScore W4387135324C126322002 @default.
- W4387135324 hasConceptScore W4387135324C135763542 @default.
- W4387135324 hasConceptScore W4387135324C139275648 @default.
- W4387135324 hasConceptScore W4387135324C143998085 @default.
- W4387135324 hasConceptScore W4387135324C153209595 @default.
- W4387135324 hasConceptScore W4387135324C2780427987 @default.
- W4387135324 hasConceptScore W4387135324C31467283 @default.
- W4387135324 hasConceptScore W4387135324C54355233 @default.
- W4387135324 hasConceptScore W4387135324C65409693 @default.
- W4387135324 hasConceptScore W4387135324C71924100 @default.
- W4387135324 hasConceptScore W4387135324C86803240 @default.
- W4387135324 hasConceptScore W4387135324C90924648 @default.
- W4387135324 hasLocation W43871353241 @default.
- W4387135324 hasOpenAccess W4387135324 @default.
- W4387135324 hasPrimaryLocation W43871353241 @default.
- W4387135324 hasRelatedWork W1504890006 @default.
- W4387135324 hasRelatedWork W1508523048 @default.
- W4387135324 hasRelatedWork W2056355462 @default.
- W4387135324 hasRelatedWork W2136530838 @default.
- W4387135324 hasRelatedWork W2164332050 @default.
- W4387135324 hasRelatedWork W2184363627 @default.
- W4387135324 hasRelatedWork W2329658823 @default.
- W4387135324 hasRelatedWork W2515707153 @default.
- W4387135324 hasRelatedWork W2790470715 @default.
- W4387135324 hasRelatedWork W4246971673 @default.
- W4387135324 isParatext "false" @default.
- W4387135324 isRetracted "false" @default.
- W4387135324 workType "article" @default.