Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387136306> ?p ?o ?g. }
- W4387136306 endingPage "2018" @default.
- W4387136306 startingPage "2018" @default.
- W4387136306 abstract "Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by severe acute respiratory syndrome coronavirus 2 that can have detrimental effects on multiple organs and accelerate patient mortality. This study, which encompassed 130 confirmed COVID-19 patients who were assessed at three different time points (i.e., 3, 7, and 12 days) after the onset of symptoms, investigated interleukin-6 (IL-6) enhancement induced by a viral nucleocapsid (N) protein from a myeloid cell line. Disease severity was categorized as mild, moderate, or severe. The severe cases were characterized as having significant elevations in serum IL-6, C-reactive protein, D-dimer, ferritin, creatinine, leukocytes, and neutrophil-to-lymphocyte ratio and decreased hemoglobin, hematocrit, and albumin levels compared with mild and moderate cases. To evaluate IL-6-inducing activity, heat-inactivated sera from these patients were incubated with and without the N protein. The findings showed a progressive increase in IL-6 production in severe cases upon N protein stimulation. There was a strong correlation between anti-N antibodies and levels of IL-6 secreted by myeloid cells in the presence of N protein and sera, indicating the crucial role that the anti-N antibody plays in inducing IL-6 production. Uncontrolled IL-6 production played a pivotal role in disease pathogenesis, exacerbating both disease severity and mortality. Efficiently targeting the N protein could potentially be employed as a therapeutic strategy for regulating the immune response and alleviating inflammation in severe cases." @default.
- W4387136306 created "2023-09-29" @default.
- W4387136306 creator A5012316730 @default.
- W4387136306 creator A5013313099 @default.
- W4387136306 creator A5018970286 @default.
- W4387136306 creator A5023013637 @default.
- W4387136306 creator A5029370191 @default.
- W4387136306 creator A5050207125 @default.
- W4387136306 creator A5078493421 @default.
- W4387136306 date "2023-09-28" @default.
- W4387136306 modified "2023-10-18" @default.
- W4387136306 title "Enhancement of IL-6 Production Induced by SARS-CoV-2 Nucleocapsid Protein and Bangladeshi COVID-19 Patients’ Sera" @default.
- W4387136306 cites W1867422291 @default.
- W4387136306 cites W2001975441 @default.
- W4387136306 cites W2019466258 @default.
- W4387136306 cites W2123063376 @default.
- W4387136306 cites W2148658155 @default.
- W4387136306 cites W2892710900 @default.
- W4387136306 cites W3001118548 @default.
- W4387136306 cites W3004318991 @default.
- W4387136306 cites W3004896487 @default.
- W4387136306 cites W3009834387 @default.
- W4387136306 cites W3009885589 @default.
- W4387136306 cites W3010848803 @default.
- W4387136306 cites W3011398105 @default.
- W4387136306 cites W3011610993 @default.
- W4387136306 cites W3011978530 @default.
- W4387136306 cites W3013486442 @default.
- W4387136306 cites W3013657010 @default.
- W4387136306 cites W3013789297 @default.
- W4387136306 cites W3014003872 @default.
- W4387136306 cites W3014130682 @default.
- W4387136306 cites W3015522797 @default.
- W4387136306 cites W3016987930 @default.
- W4387136306 cites W3017125154 @default.
- W4387136306 cites W3018517500 @default.
- W4387136306 cites W3020710323 @default.
- W4387136306 cites W3023770076 @default.
- W4387136306 cites W3025699671 @default.
- W4387136306 cites W3027002382 @default.
- W4387136306 cites W3032427039 @default.
- W4387136306 cites W3033925668 @default.
- W4387136306 cites W3033975073 @default.
- W4387136306 cites W3038020440 @default.
- W4387136306 cites W3041985244 @default.
- W4387136306 cites W3080654873 @default.
- W4387136306 cites W3080981445 @default.
- W4387136306 cites W3085023571 @default.
- W4387136306 cites W3087128437 @default.
- W4387136306 cites W3088315869 @default.
- W4387136306 cites W3089203609 @default.
- W4387136306 cites W3091337946 @default.
- W4387136306 cites W3092623037 @default.
- W4387136306 cites W3102695835 @default.
- W4387136306 cites W3105246410 @default.
- W4387136306 cites W3107068086 @default.
- W4387136306 cites W3112344668 @default.
- W4387136306 cites W3119894254 @default.
- W4387136306 cites W3122391279 @default.
- W4387136306 cites W3126490915 @default.
- W4387136306 cites W3127096906 @default.
- W4387136306 cites W3129397954 @default.
- W4387136306 cites W3130206057 @default.
- W4387136306 cites W3131820551 @default.
- W4387136306 cites W3155942906 @default.
- W4387136306 cites W3159004417 @default.
- W4387136306 cites W3173986059 @default.
- W4387136306 cites W3183892249 @default.
- W4387136306 cites W3184579305 @default.
- W4387136306 cites W3191928958 @default.
- W4387136306 cites W3205265340 @default.
- W4387136306 cites W3207328751 @default.
- W4387136306 cites W4200214948 @default.
- W4387136306 cites W4200219961 @default.
- W4387136306 cites W4205708037 @default.
- W4387136306 cites W4205823334 @default.
- W4387136306 cites W4207050246 @default.
- W4387136306 cites W4210575617 @default.
- W4387136306 cites W4225471573 @default.
- W4387136306 cites W4280603197 @default.
- W4387136306 cites W4289884217 @default.
- W4387136306 cites W4293680676 @default.
- W4387136306 cites W4308767470 @default.
- W4387136306 cites W4324143397 @default.
- W4387136306 cites W4365515075 @default.
- W4387136306 cites W4376134785 @default.
- W4387136306 cites W4378212766 @default.
- W4387136306 cites W4384298486 @default.
- W4387136306 cites W4386085585 @default.
- W4387136306 cites W4386460846 @default.
- W4387136306 doi "https://doi.org/10.3390/v15102018" @default.
- W4387136306 hasPublicationYear "2023" @default.
- W4387136306 type Work @default.
- W4387136306 citedByCount "0" @default.
- W4387136306 crossrefType "journal-article" @default.
- W4387136306 hasAuthorship W4387136306A5012316730 @default.
- W4387136306 hasAuthorship W4387136306A5013313099 @default.
- W4387136306 hasAuthorship W4387136306A5018970286 @default.