Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387136802> ?p ?o ?g. }
- W4387136802 abstract "Inter-organ crosstalk has gained increasing attention in recent times; however, the underlying mechanisms remain unclear. In this study, we elucidate an endocrine pathway that is regulated by skeletal muscle interferon regulatory factor (IRF) 4, which manipulates liver pathology. Skeletal muscle specific IRF4 knockout (F4MKO) mice exhibited ameliorated hepatic steatosis, inflammation, and fibrosis, without changes in body weight, when put on a nonalcoholic steatohepatitis (NASH) diet. Proteomics analysis results suggested that follistatin-like protein 1 (FSTL1) may constitute a link between muscles and the liver. Dual luciferase assays showed that IRF4 can transcriptionally regulate FSTL1. Further, inducing FSTL1 expression in the muscles of F4MKO mice is sufficient to restore liver pathology. In addition, co-culture experiments confirmed that FSTL1 plays a distinct role in various liver cell types via different receptors. Finally, we observed that the serum FSTL1 level is positively correlated with NASH progression in humans. These data indicate a signaling pathway involving IRF4-FSTL1-DIP2A/CD14, that links skeletal muscle cells to the liver in the pathogenesis of NASH." @default.
- W4387136802 created "2023-09-29" @default.
- W4387136802 creator A5011592007 @default.
- W4387136802 creator A5018365310 @default.
- W4387136802 creator A5022175957 @default.
- W4387136802 creator A5039545694 @default.
- W4387136802 creator A5053392436 @default.
- W4387136802 creator A5065049243 @default.
- W4387136802 creator A5069309926 @default.
- W4387136802 creator A5071078640 @default.
- W4387136802 creator A5071185537 @default.
- W4387136802 creator A5073979546 @default.
- W4387136802 creator A5079052592 @default.
- W4387136802 creator A5087013074 @default.
- W4387136802 creator A5087346958 @default.
- W4387136802 creator A5090366405 @default.
- W4387136802 date "2023-09-28" @default.
- W4387136802 modified "2023-10-17" @default.
- W4387136802 title "Metabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in nonalcoholic steatohepatitis" @default.
- W4387136802 cites W1964873147 @default.
- W4387136802 cites W2002771508 @default.
- W4387136802 cites W2008359713 @default.
- W4387136802 cites W2012460974 @default.
- W4387136802 cites W2013579877 @default.
- W4387136802 cites W2035938902 @default.
- W4387136802 cites W2067740038 @default.
- W4387136802 cites W2077291760 @default.
- W4387136802 cites W2079614660 @default.
- W4387136802 cites W2092172804 @default.
- W4387136802 cites W2099787589 @default.
- W4387136802 cites W2117457995 @default.
- W4387136802 cites W2120569915 @default.
- W4387136802 cites W2128788344 @default.
- W4387136802 cites W2132067866 @default.
- W4387136802 cites W2139654088 @default.
- W4387136802 cites W2140899843 @default.
- W4387136802 cites W2268067733 @default.
- W4387136802 cites W2272188229 @default.
- W4387136802 cites W2283843704 @default.
- W4387136802 cites W2404306813 @default.
- W4387136802 cites W2473248170 @default.
- W4387136802 cites W2532034373 @default.
- W4387136802 cites W2548399475 @default.
- W4387136802 cites W2554433662 @default.
- W4387136802 cites W2576488295 @default.
- W4387136802 cites W2607011262 @default.
- W4387136802 cites W2627050072 @default.
- W4387136802 cites W2742613651 @default.
- W4387136802 cites W2754145804 @default.
- W4387136802 cites W2777389776 @default.
- W4387136802 cites W2795549750 @default.
- W4387136802 cites W2804042740 @default.
- W4387136802 cites W2883203008 @default.
- W4387136802 cites W2885053098 @default.
- W4387136802 cites W2904043661 @default.
- W4387136802 cites W2911080438 @default.
- W4387136802 cites W2924084550 @default.
- W4387136802 cites W2959518441 @default.
- W4387136802 cites W2959566316 @default.
- W4387136802 cites W2968872536 @default.
- W4387136802 cites W3002055665 @default.
- W4387136802 cites W3035103197 @default.
- W4387136802 cites W3041782072 @default.
- W4387136802 cites W3046326265 @default.
- W4387136802 cites W3095186004 @default.
- W4387136802 cites W3098031338 @default.
- W4387136802 cites W3107038321 @default.
- W4387136802 cites W3143409077 @default.
- W4387136802 cites W3162364106 @default.
- W4387136802 cites W3177283014 @default.
- W4387136802 cites W3200425833 @default.
- W4387136802 cites W4206648120 @default.
- W4387136802 cites W4210895382 @default.
- W4387136802 cites W4221105933 @default.
- W4387136802 cites W4225413323 @default.
- W4387136802 cites W4280503962 @default.
- W4387136802 cites W4283012041 @default.
- W4387136802 cites W4313237264 @default.
- W4387136802 cites W4321436187 @default.
- W4387136802 doi "https://doi.org/10.1038/s41467-023-41832-3" @default.
- W4387136802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37770480" @default.
- W4387136802 hasPublicationYear "2023" @default.
- W4387136802 type Work @default.
- W4387136802 citedByCount "0" @default.
- W4387136802 crossrefType "journal-article" @default.
- W4387136802 hasAuthorship W4387136802A5011592007 @default.
- W4387136802 hasAuthorship W4387136802A5018365310 @default.
- W4387136802 hasAuthorship W4387136802A5022175957 @default.
- W4387136802 hasAuthorship W4387136802A5039545694 @default.
- W4387136802 hasAuthorship W4387136802A5053392436 @default.
- W4387136802 hasAuthorship W4387136802A5065049243 @default.
- W4387136802 hasAuthorship W4387136802A5069309926 @default.
- W4387136802 hasAuthorship W4387136802A5071078640 @default.
- W4387136802 hasAuthorship W4387136802A5071185537 @default.
- W4387136802 hasAuthorship W4387136802A5073979546 @default.
- W4387136802 hasAuthorship W4387136802A5079052592 @default.
- W4387136802 hasAuthorship W4387136802A5087013074 @default.
- W4387136802 hasAuthorship W4387136802A5087346958 @default.
- W4387136802 hasAuthorship W4387136802A5090366405 @default.
- W4387136802 hasBestOaLocation W43871368021 @default.