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- W4387138367 abstract "The development of novel excipients with enhanced functionality has been explored using particle engineering by co-processing. The aim of this study was to improve the functionality of Lapidium Sativum for direct compression by co-processing with MCC pH 101 and PVP K30 in optimized proportions. Design of Experiment (DoE) was employed to optimize the composition of the co-processed excipient using the desirability function and other supporting studies as a basis for selecting the optimized formulation. The co-processed excipient was thereafter developed by the method of spraydrying. Flow and compaction studies of coprocessed excipient were carried out in comparison to its parent component and physical mixture. Tablets were prepared by direct compression (DC) containing Venlafaxine hydrochloride (100 mg) as a model for poor compressibility. Tablets produced with CPE were satisfactory and conformed to USP specifications for acceptable tablets. The application of DoE was successful in optimizing and developing a starch-based co-processed excipient that can be considered for direct compression tableting." @default.
- W4387138367 created "2023-09-29" @default.
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- W4387138367 date "2022-05-31" @default.
- W4387138367 modified "2023-10-18" @default.
- W4387138367 title "Application of design of experiments for development and characterization of coprocessed excipients using Lapidium Sativum" @default.
- W4387138367 doi "https://doi.org/10.53730/ijhs.v6ns8.14573" @default.
- W4387138367 hasPublicationYear "2022" @default.
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