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• W4387140147 abstract "Sex differences have been observed in the development of obesity-related complications in patients, as well as in animal models. Accumulating evidence suggests that sex-dependent regulation of lipid metabolism contributes to sex-specific physiopathology. Lipid accumulation in the renal tissue has been shown to play a major role in the pathogenesis of obesity-induced kidney injury. Unlike in males, the physiopathology of the disease has been poorly described in females, particularly regarding the lipid metabolism adaptation.Here, we compared the lipid profile changes in the kidneys of female and male mice fed a high-fat diet (HFD) or low-fat diet (LFD) by lipidomics and correlated them with pathophysiological changes.We showed that HFD-fed female mice were protected from insulin resistance and hepatic steatosis compared to males, despite similar body weight gains. Females were particularly protected from renal dysfunction, oxidative stress, and tubular lipid accumulation. Both HFD-fed male and female mice presented dyslipidemia, but lipidomic analysis highlighted differential renal lipid profiles. While both sexes presented similar neutral lipid accumulation with obesity, only males showed increased levels of ceramides and phospholipids. Remarkably, protection against renal lipotoxicity in females was associated with enhanced renal adiponectin and AMP-activated protein kinase (AMPK) signaling. Circulating adiponectin and its renal receptor levels were significantly lower in obese males, but were maintained in females. This observation correlated with the maintained basal AMPK activity in obese female mice compared to males.Collectively, our findings suggest that female mice are protected from obesity-induced renal dysfunction and lipotoxicity associated with enhanced adiponectin and AMPK signaling compared to males.Obesity-related complications can differ between men and women due to sex-specific differences in how fats are handled. Here, we studied the effects of high-fat diet on the kidneys of male and female mice. We found that despite gaining similar weight, obese female mice were better protected against insulin resistance, liver fat accumulation, and kidney damage caused by obesity than males. In particular, female mice were protected against lipid accumulation in the kidneys. We further analyzed the lipid profile in the kidneys of both male and female mice and observed differences in the amount and nature of the accumulated lipids. Male mice had increased levels of specific lipids, which may contribute to their higher risk of kidney damage. In contrast, female mice showed better lipid metabolism adaptation, which helped to protect their kidneys. This study also revealed an association between higher levels of the protein hormone adiponectin and higher activity of the cellular energy master regulator protein AMPK in obese females. These proteins may help prevent obesity-induced kidney damage. In obese males, these protective proteins are reduced and are associated with kidney damage. In conclusion, this study suggests that female mice are naturally shielded from obesity-induced kidney damage and lipid accumulation in the kidneys. Obesity in males is associated with the presence of potentially toxic lipids and dysregulated renal metabolism. Understanding these sex-related differences in obesity-related complications could lead to better management and treatment of kidney problems in both men and women." @default.
• W4387140147 created "2023-09-29" @default.
• W4387140147 creator A5010847260 @default.
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• W4387140147 creator A5088186930 @default.
• W4387140147 date "2023-09-28" @default.
• W4387140147 modified "2023-10-18" @default.
• W4387140147 title "Sex differences in obesity-induced renal lipid accumulation revealed by lipidomics: a role of adiponectin/AMPK axis" @default.
• W4387140147 cites W100734209 @default.
• W4387140147 cites W1783727169 @default.
• W4387140147 cites W1900339045 @default.
• W4387140147 cites W1911315538 @default.
• W4387140147 cites W1978804351 @default.
• W4387140147 cites W1983844571 @default.
• W4387140147 cites W2017073557 @default.
• W4387140147 cites W2035075611 @default.
• W4387140147 cites W2041046678 @default.
• W4387140147 cites W2042706232 @default.
• W4387140147 cites W2049368067 @default.
• W4387140147 cites W2050622384 @default.
• W4387140147 cites W2055882364 @default.
• W4387140147 cites W2074384047 @default.
• W4387140147 cites W2078575306 @default.
• W4387140147 cites W2093166479 @default.
• W4387140147 cites W2094077779 @default.
• W4387140147 cites W2094719535 @default.
• W4387140147 cites W2099729330 @default.
• W4387140147 cites W2101221312 @default.
• W4387140147 cites W2102776209 @default.
• W4387140147 cites W2106919088 @default.
• W4387140147 cites W2110174113 @default.
• W4387140147 cites W2110846796 @default.
• W4387140147 cites W2120001839 @default.
• W4387140147 cites W2125528261 @default.
• W4387140147 cites W2128485668 @default.
• W4387140147 cites W2134100055 @default.
• W4387140147 cites W2135985828 @default.
• W4387140147 cites W2141759136 @default.
• W4387140147 cites W2148383459 @default.
• W4387140147 cites W2154979016 @default.
• W4387140147 cites W2155492217 @default.
• W4387140147 cites W2317113145 @default.
• W4387140147 cites W2341462106 @default.
• W4387140147 cites W2342063582 @default.
• W4387140147 cites W2345328813 @default.
• W4387140147 cites W2412136682 @default.
• W4387140147 cites W2415080161 @default.
• W4387140147 cites W2461706302 @default.
• W4387140147 cites W2472849417 @default.
• W4387140147 cites W2483176502 @default.
• W4387140147 cites W2528626298 @default.
• W4387140147 cites W2560569403 @default.
• W4387140147 cites W2574600628 @default.
• W4387140147 cites W2587125180 @default.
• W4387140147 cites W2606214113 @default.
• W4387140147 cites W2617130129 @default.
• W4387140147 cites W2687247097 @default.
• W4387140147 cites W2755212013 @default.
• W4387140147 cites W2763871199 @default.
• W4387140147 cites W2767476494 @default.
• W4387140147 cites W2767518162 @default.
• W4387140147 cites W2783996679 @default.
• W4387140147 cites W2785099367 @default.
• W4387140147 cites W2785494437 @default.
• W4387140147 cites W2789346990 @default.
• W4387140147 cites W2794972088 @default.
• W4387140147 cites W2797188197 @default.
• W4387140147 cites W2802035371 @default.
• W4387140147 cites W2803173125 @default.
• W4387140147 cites W2885907124 @default.
• W4387140147 cites W2886908391 @default.
• W4387140147 cites W2889828289 @default.
• W4387140147 cites W2895752892 @default.
• W4387140147 cites W2916737553 @default.
• W4387140147 cites W2917520831 @default.
• W4387140147 cites W2922171607 @default.
• W4387140147 cites W2934946727 @default.
• W4387140147 cites W2956882737 @default.
• W4387140147 cites W2977588109 @default.
• W4387140147 cites W3011607553 @default.
• W4387140147 cites W3016656470 @default.
• W4387140147 cites W3096834656 @default.
• W4387140147 cites W3097883702 @default.
• W4387140147 cites W3106784357 @default.
• W4387140147 cites W3108612234 @default.
• W4387140147 cites W3111988148 @default.
• W4387140147 cites W3113130781 @default.
• W4387140147 cites W3116978215 @default.
• W4387140147 cites W3128480436 @default.
• W4387140147 cites W3128876677 @default.
• W4387140147 cites W3135082194 @default.
• W4387140147 cites W3137800822 @default.
• W4387140147 cites W3201264063 @default.

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