FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387141318> ?p ?o ?g. }

• W4387141318 abstract "Trigeminal neuropathic pain (TNP) induces mechanical allodynia and hyperalgesia, which are known to alter gene expression in injured dorsal root ganglia primary sensory neurons. Non-coding RNAs (ncRNAs) have been linked to TNP. However, the functional mechanism underlying TNP and the expression profile of ncRNAs in the trigeminal ganglion (TG) and trigeminal subnucleus caudalis (Sp5C) are still unknown. We used RNA sequencing and bioinformatics analysis to examine the TG and Sp5C transcriptomes after infraorbital nerve chronic constrictive injury (IoN-CCI). The robust changes in the gene expression of lncRNAs, circRNAs, and mRNAs were observed within the TG and Sp5C from mice that underwent IoN-CCI and the sham-operated mice (day 7). In total, 111,003 lncRNAs were found in TG and 107,157 in Sp5C; 369 lncRNAs were differentially expressed in TG, and 279 lncRNAs were differentially expressed in Sp5C. In addition, 13,216 circRNAs in TG and 21,658 circRNAs in Sp5C were identified, with 1,155 circRNAs and 2,097 circRNAs differentially expressed in TG and Sp5C, respectively. Furthermore, 5,205 DE mRNAs in TG and 3,934 DE mRNAs in Sp5C were differentially expressed between IoN-CCI and sham groups. The study revealed a high correlation of pain-related differentially expressed genes in the TG and Sp5C to anxiety, depression, inflammation, neuroinflammation, and apoptosis. Gene Ontology analysis revealed that binding-related molecular functions and membrane-related cell components were significantly enriched. Kyoto Encyclopedia of Genes and Genomes analysis shows the most significant enrichments in neurogenesis, nervous system development, neuron differentiation, adrenergic signaling, cAMP signaling, MAPK signaling, and PI3K-Akt signaling pathways. Furthermore, protein-protein interaction analysis showed that hub genes were implicated in neuropeptide signaling pathways. Functional analysis of DE ncRNA-targeting genes was mostly enriched with nociception-related signaling pathways underpinning TNP. Our findings suggest that ncRNAs are involved in TNP development and open new avenues for research and treatment." @default.
• W4387141318 created "2023-09-29" @default.
• W4387141318 creator A5014068004 @default.
• W4387141318 creator A5047559972 @default.
• W4387141318 creator A5049946380 @default.
• W4387141318 creator A5051936426 @default.
• W4387141318 creator A5055396925 @default.
• W4387141318 creator A5063392279 @default.
• W4387141318 creator A5081329695 @default.
• W4387141318 creator A5087761452 @default.
• W4387141318 date "2023-09-28" @default.
• W4387141318 modified "2023-10-18" @default.
• W4387141318 title "Transcriptome-wide analysis of trigeminal ganglion and subnucleus caudalis in a mouse model of chronic constriction injury-induced trigeminal neuralgia" @default.
• W4387141318 cites W1482210486 @default.
• W4387141318 cites W1966380247 @default.
• W4387141318 cites W1988469889 @default.
• W4387141318 cites W2001819587 @default.
• W4387141318 cites W2028525915 @default.
• W4387141318 cites W2037791777 @default.
• W4387141318 cites W2042161082 @default.
• W4387141318 cites W2060424507 @default.
• W4387141318 cites W2064384972 @default.
• W4387141318 cites W2073035767 @default.
• W4387141318 cites W2077358692 @default.
• W4387141318 cites W2088596771 @default.
• W4387141318 cites W2092018159 @default.
• W4387141318 cites W2100268153 @default.
• W4387141318 cites W2105435400 @default.
• W4387141318 cites W2106753138 @default.
• W4387141318 cites W2113899525 @default.
• W4387141318 cites W2122380052 @default.
• W4387141318 cites W2128419930 @default.
• W4387141318 cites W2146306684 @default.
• W4387141318 cites W2169306262 @default.
• W4387141318 cites W229707950 @default.
• W4387141318 cites W2322838495 @default.
• W4387141318 cites W2403615685 @default.
• W4387141318 cites W2535260250 @default.
• W4387141318 cites W2559423216 @default.
• W4387141318 cites W2598940724 @default.
• W4387141318 cites W2766064152 @default.
• W4387141318 cites W2786697307 @default.
• W4387141318 cites W2800072530 @default.
• W4387141318 cites W2801899575 @default.
• W4387141318 cites W2887185357 @default.
• W4387141318 cites W2893413429 @default.
• W4387141318 cites W2901132121 @default.
• W4387141318 cites W2969787838 @default.
• W4387141318 cites W2972331748 @default.
• W4387141318 cites W3008695958 @default.
• W4387141318 cites W3010964004 @default.
• W4387141318 cites W3015182071 @default.
• W4387141318 cites W3020424199 @default.
• W4387141318 cites W3036589033 @default.
• W4387141318 cites W3037975981 @default.
• W4387141318 cites W3040021648 @default.
• W4387141318 cites W3041078089 @default.
• W4387141318 cites W3081448808 @default.
• W4387141318 cites W3083774546 @default.
• W4387141318 cites W3091796652 @default.
• W4387141318 cites W3096753387 @default.
• W4387141318 cites W3100514562 @default.
• W4387141318 cites W3140495609 @default.
• W4387141318 cites W3155481358 @default.
• W4387141318 cites W3161993331 @default.
• W4387141318 cites W3169915509 @default.
• W4387141318 cites W3180474968 @default.
• W4387141318 cites W3183683223 @default.
• W4387141318 cites W3185449915 @default.
• W4387141318 cites W4200546910 @default.
• W4387141318 cites W4229033002 @default.
• W4387141318 cites W4247113585 @default.
• W4387141318 cites W4249439368 @default.
• W4387141318 cites W4281286187 @default.
• W4387141318 cites W4283716882 @default.
• W4387141318 cites W4283735389 @default.
• W4387141318 cites W4286655741 @default.
• W4387141318 cites W4291940997 @default.
• W4387141318 cites W4296720263 @default.
• W4387141318 cites W4385522181 @default.
• W4387141318 doi "https://doi.org/10.3389/fphar.2023.1230633" @default.
• W4387141318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37841912" @default.
• W4387141318 hasPublicationYear "2023" @default.
• W4387141318 type Work @default.
• W4387141318 citedByCount "0" @default.
• W4387141318 crossrefType "journal-article" @default.
• W4387141318 hasAuthorship W4387141318A5014068004 @default.
• W4387141318 hasAuthorship W4387141318A5047559972 @default.
• W4387141318 hasAuthorship W4387141318A5049946380 @default.
• W4387141318 hasAuthorship W4387141318A5051936426 @default.
• W4387141318 hasAuthorship W4387141318A5055396925 @default.
• W4387141318 hasAuthorship W4387141318A5063392279 @default.
• W4387141318 hasAuthorship W4387141318A5081329695 @default.
• W4387141318 hasAuthorship W4387141318A5087761452 @default.
• W4387141318 hasBestOaLocation W43871413181 @default.
• W4387141318 hasConcept C104317684 @default.
• W4387141318 hasConcept C150194340 @default.
• W4387141318 hasConcept C152724338 @default.
• W4387141318 hasConcept C153911025 @default.
• W4387141318 hasConcept C15490471 @default.

• next