Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387142785> ?p ?o ?g. }
- W4387142785 endingPage "113871" @default.
- W4387142785 startingPage "113871" @default.
- W4387142785 abstract "Five undescribed eudesmane sesquiterpenoids, artemilavanins A-E, and one undescribed rearranged eudesmane sesquiterpenoid, artemilavanin F, were isolated from the 95% ethanol extract of the aerial parts of Artemisia lavandulaefolia DC., along with ten known compounds. The structures and configurations of undescribed compounds were mainly elucidated by spectroscopic analyses and single-crystal X-ray diffraction analysis. Among all isolated compounds, artemilavanin F exhibited inhibitory activity on PANC-1 pancreatic cancer cells with IC50 of 9.69 ± 2.39 μM. Artemilavanin F inhibited PANC-1 cell proliferation by induction of G2/M cell cycle arrest and apoptosis mediated by downregulation of cyclin-dependent kinases and accumulation of reactive oxygen species. Moreover, artemilavanin F inhibited the colony formation, cell migration and sphere formation of PANC-1 cells, indicating the suppression of stem-cell-like phenotype of PANC-1 cells. Further results confirmed that the expression of cancer stem cell markers such as Bmi1, CD44, CD133 were inhibited by artemilavanin F. Downregulation of epithelial-mesenchymal transition (EMT) markers such as N-cadherin and Oct-4 indicated the potential of artemilavanin F in prevention of metastasis." @default.
- W4387142785 created "2023-09-29" @default.
- W4387142785 creator A5001895678 @default.
- W4387142785 creator A5010345518 @default.
- W4387142785 creator A5013299868 @default.
- W4387142785 creator A5028602125 @default.
- W4387142785 creator A5038807397 @default.
- W4387142785 creator A5043138631 @default.
- W4387142785 creator A5047890181 @default.
- W4387142785 creator A5070022027 @default.
- W4387142785 creator A5090394062 @default.
- W4387142785 date "2023-12-01" @default.
- W4387142785 modified "2023-10-12" @default.
- W4387142785 title "Eudesmane-type sesquiterpenoids from the aerial parts of Artemisia lavandulaefolia and their anti-pancreatic cancer activities" @default.
- W4387142785 cites W1964296201 @default.
- W4387142785 cites W1971225631 @default.
- W4387142785 cites W1973818886 @default.
- W4387142785 cites W1979144600 @default.
- W4387142785 cites W1979174561 @default.
- W4387142785 cites W2009376893 @default.
- W4387142785 cites W2040321671 @default.
- W4387142785 cites W2078056299 @default.
- W4387142785 cites W2084800809 @default.
- W4387142785 cites W2120489158 @default.
- W4387142785 cites W2185500533 @default.
- W4387142785 cites W2315174739 @default.
- W4387142785 cites W2594538327 @default.
- W4387142785 cites W2624576378 @default.
- W4387142785 cites W2669988692 @default.
- W4387142785 cites W2752806824 @default.
- W4387142785 cites W2807250734 @default.
- W4387142785 cites W2902580396 @default.
- W4387142785 cites W2908559708 @default.
- W4387142785 cites W2953574321 @default.
- W4387142785 cites W2998610126 @default.
- W4387142785 cites W3013690428 @default.
- W4387142785 cites W3043142299 @default.
- W4387142785 cites W3045497015 @default.
- W4387142785 cites W3080955746 @default.
- W4387142785 cites W3088093311 @default.
- W4387142785 cites W3089863714 @default.
- W4387142785 cites W3096069818 @default.
- W4387142785 cites W3113168029 @default.
- W4387142785 cites W3153729378 @default.
- W4387142785 cites W3162629725 @default.
- W4387142785 cites W3197559541 @default.
- W4387142785 cites W4307848639 @default.
- W4387142785 cites W4308627652 @default.
- W4387142785 cites W4312052239 @default.
- W4387142785 cites W4361283999 @default.
- W4387142785 doi "https://doi.org/10.1016/j.phytochem.2023.113871" @default.
- W4387142785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37777165" @default.
- W4387142785 hasPublicationYear "2023" @default.
- W4387142785 type Work @default.
- W4387142785 citedByCount "0" @default.
- W4387142785 crossrefType "journal-article" @default.
- W4387142785 hasAuthorship W4387142785A5001895678 @default.
- W4387142785 hasAuthorship W4387142785A5010345518 @default.
- W4387142785 hasAuthorship W4387142785A5013299868 @default.
- W4387142785 hasAuthorship W4387142785A5028602125 @default.
- W4387142785 hasAuthorship W4387142785A5038807397 @default.
- W4387142785 hasAuthorship W4387142785A5043138631 @default.
- W4387142785 hasAuthorship W4387142785A5047890181 @default.
- W4387142785 hasAuthorship W4387142785A5070022027 @default.
- W4387142785 hasAuthorship W4387142785A5090394062 @default.
- W4387142785 hasConcept C104317684 @default.
- W4387142785 hasConcept C121608353 @default.
- W4387142785 hasConcept C127561419 @default.
- W4387142785 hasConcept C1491633281 @default.
- W4387142785 hasConcept C185592680 @default.
- W4387142785 hasConcept C190283241 @default.
- W4387142785 hasConcept C2780210213 @default.
- W4387142785 hasConcept C2780932548 @default.
- W4387142785 hasConcept C29537977 @default.
- W4387142785 hasConcept C54355233 @default.
- W4387142785 hasConcept C55493867 @default.
- W4387142785 hasConcept C81885089 @default.
- W4387142785 hasConcept C86803240 @default.
- W4387142785 hasConceptScore W4387142785C104317684 @default.
- W4387142785 hasConceptScore W4387142785C121608353 @default.
- W4387142785 hasConceptScore W4387142785C127561419 @default.
- W4387142785 hasConceptScore W4387142785C1491633281 @default.
- W4387142785 hasConceptScore W4387142785C185592680 @default.
- W4387142785 hasConceptScore W4387142785C190283241 @default.
- W4387142785 hasConceptScore W4387142785C2780210213 @default.
- W4387142785 hasConceptScore W4387142785C2780932548 @default.
- W4387142785 hasConceptScore W4387142785C29537977 @default.
- W4387142785 hasConceptScore W4387142785C54355233 @default.
- W4387142785 hasConceptScore W4387142785C55493867 @default.
- W4387142785 hasConceptScore W4387142785C81885089 @default.
- W4387142785 hasConceptScore W4387142785C86803240 @default.
- W4387142785 hasLocation W43871427851 @default.
- W4387142785 hasLocation W43871427852 @default.
- W4387142785 hasOpenAccess W4387142785 @default.
- W4387142785 hasPrimaryLocation W43871427851 @default.
- W4387142785 hasRelatedWork W1973986230 @default.
- W4387142785 hasRelatedWork W2026862129 @default.
- W4387142785 hasRelatedWork W2079638808 @default.