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- W4387142805 abstract "Environmental benzo(a)pyrene (BaP) and its ultimate metabolite BPDE (benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide) are universal and inevitable persistent organic pollutants and endocrine disrupting chemicals. Angiogenesis in placental decidua plays a pivotal role in healthy pregnancy. Ferroptosis is a newly identified and iron-dependent cell death mode. However, till now, BaP/BPDE exposure, ferroptosis, defective angiogenesis, and miscarriage have never been correlated; and their regulatory mechanisms have been rarely explored. In this study, we used assays with BPDE-exposed HUVECs (human umbilical vein endothelial cells), decidual tissues and serum samples collected from unexplained recurrent miscarriage and their matched healthy control groups, and placental tissues of BaP-exposed mouse miscarriage model. We found that BaP/BPDE exposure caused ferroptosis and then directly suppressed angiogenesis and eventually induced miscarriage. In mechanism, BaP/BPDE exposure up-regulated free Fe2+ level and promoted lipid peroxidation and also up-regulated MARCHF1 (a novel E3 ligase of GPX4) level to promote the ubiquitination degradation of GPX4, both of which resulted in HUVEC ferroptosis. Furthermore, we also found that GPX4 protein down-regulated the protein levels of VEGFA and ANG-1, two key proteins function for angiogenesis, and thus suppressed HUVEC angiogenesis. In turn, supplement with GPX4 could suppress ferroptosis, recover angiogenesis, and alleviate miscarriage. Moreover, the levels of free Fe2+ and VEGFA in serum might predict the risk of miscarriage. Overall, this study uncovered the crosstalk among BaP/BPDE exposure, ferroptosis, angiogenesis, and miscarriage, discovering novel toxicological effects of BaP/BPDE on human reproductive health. This study also warned the public to avoid exposure to polycyclic aromatic hydrocarbons during pregnancy to effectively prevent adverse pregnancy outcomes." @default.
- W4387142805 created "2023-09-29" @default.
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- W4387142805 date "2023-10-01" @default.
- W4387142805 modified "2023-10-08" @default.
- W4387142805 title "BaP/BPDE suppressed endothelial cell angiogenesis to induce miscarriage by promoting MARCHF1/GPX4-mediated ferroptosis" @default.
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- W4387142805 cites W2017314699 @default.
- W4387142805 cites W2018230189 @default.
- W4387142805 cites W2030669568 @default.
- W4387142805 cites W2033481153 @default.
- W4387142805 cites W2041946906 @default.
- W4387142805 cites W2051145078 @default.
- W4387142805 cites W2057265291 @default.
- W4387142805 cites W2079260294 @default.
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- W4387142805 cites W2095060605 @default.
- W4387142805 cites W211045632 @default.
- W4387142805 cites W2117574981 @default.
- W4387142805 cites W2121836743 @default.
- W4387142805 cites W2154762629 @default.
- W4387142805 cites W2168041677 @default.
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- W4387142805 cites W2921575300 @default.
- W4387142805 cites W2946704044 @default.
- W4387142805 cites W2951331974 @default.
- W4387142805 cites W2953831294 @default.
- W4387142805 cites W2975516408 @default.
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- W4387142805 cites W3154515292 @default.
- W4387142805 cites W3168539558 @default.
- W4387142805 cites W3182359680 @default.
- W4387142805 cites W4200013678 @default.
- W4387142805 cites W4200389923 @default.
- W4387142805 cites W4200397818 @default.
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- W4387142805 cites W4223955255 @default.
- W4387142805 cites W4225105528 @default.
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- W4387142805 doi "https://doi.org/10.1016/j.envint.2023.108237" @default.
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- W4387142805 hasPublicationYear "2023" @default.
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