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- W4387149189 abstract "Immunization: Enhancing the immune response to DNA vaccines Researchers are exploring strategies for improving immune responses to DNA vaccines. Eric Gowans at The University of Adelaide, Australia, and colleagues inserted DNA encoding a model antigen into a virus-like membrane. Mice that inhaled this vaccine and then had it injected into their skin showed a robust immune response in mucosal surfaces including the vagina. These mucosal responses are key determinants of a vaccine's efficacy against sexually transmitted diseases. A second approach examined the effect of encoding a cytolytic protein in the DNA vaccine. This showed that an optimum balance between expression of the immunogen and the cytolytic protein increased immune responses, resulting from cross presentation of the immunogen. DNA vaccines are cheap to make and easy to store, making them ideal for use in developing countries, but it is currently difficult to get them to generate a sufficient immune response." @default.
- W4387149189 created "2023-09-29" @default.
- W4387149189 date "2014-06-01" @default.
- W4387149189 modified "2023-09-29" @default.
- W4387149189 doi "https://doi.org/10.1002/cti2.2014.3.issue-6" @default.
- W4387149189 hasPublicationYear "2014" @default.
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