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- W4387157465 abstract "To assess the level and correlates of biomarker-confirmed adherence to isoniazid (INH) preventive therapy (IPT) among children living with HIV (CLHIV).This prospective cohort study assessed adherence among CLHIV on IPT in public sector HIV clinics from 2019 through 2020.Adherence was assessed by pill counts or caregiver- or self-reports, and urine biomarkers (in-house dipstick and IsoscreenTM©). Both urine biomarker tests detect INH metabolites within 48 hours of ingestion. Consistent adherence was defined as having positive results on either biomarker at all visits. Correlates of biomarker-confirmed nonadherence at each visit were evaluated using generalized estimating equations. The in-house dipstick was validated using IsoscreenTM© as the reference.Among 97 CLHIV on IPT with adherence assessments, median age was 10 years (IQR 7-13). All were on ART at IPT initiation (median duration 46 months [IQR 4-89]); 81% were virally suppressed (<1000 copies/ml). At all visits, 59% (n = 57) of CLHIV reported taking ≥80% of their doses, while 39% (n = 38) had biomarker-confirmed adherence. Viral non-suppression (adjusted risk ratio [aRR] = 1.65; 95% CI 1.09 - 2.49) and the sixth month of IPT use (aRR = 2.49; 95% CI 1.34 - 4.65) were independent correlates of biomarker-confirmed nonadherence at each visit. Sensitivity and specificity of the in-house dipstick were 98.1% (94.7% - 99.6%) and 94.7% (88.1% - 98.3%), respectively, versus IsoscreenTM©.Biomarker-confirmed adherence to IPT was sub-optimal and was associated with viral non-suppression and duration of IPT. Urine dipstick testing may be useful in assessing adherence to IPT in clinical care." @default.
- W4387157465 created "2023-09-30" @default.
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- W4387157465 date "2023-09-29" @default.
- W4387157465 modified "2023-09-30" @default.
- W4387157465 title "Biomarker-confirmed suboptimal adherence to isoniazid preventive therapy among children living with HIV in western Kenya" @default.
- W4387157465 doi "https://doi.org/10.1097/qad.0000000000003719" @default.
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