Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387158896> ?p ?o ?g. }
- W4387158896 abstract "Both epidemiological and preclinical studies have shown the benefits of n-3 polyunsaturated fatty acid (n-3 PUFA) on dementia and cognitive impairment, yet the results of clinical randomized controlled trials (RCTs) performed to date are conflicting. The difference in the baseline omega-3 index (O3i) of subjects is a potential cause for this disparity, yet this is usually ignored. The present meta-analysis aimed to evaluate the effect of n-3 polyunsaturated fatty acid (n-3 PUFA) on cognitive function in the elderly and the role of baseline O3i. A systematic literature search was conducted in PubMed, Embase, Cochrane Library, and Web of Science up to June 27th, 2023. The mean changes in the mini-mental state examination (MMSE) score were calculated as weighted mean differences by using a fixed-effects model. Fifteen random controlled trials were included in the meta-analysis. Pooled analysis showed that n-3 PUFA supplementation did not significantly improve the MMSE score (WMD = 0.04, [-0.08, 0.16]; Z = 0.62, P = 0.53; I2 = 0.00%, P(I2) = 0.49). Out of the 15 studies included in the meta-analysis, only 7 reported O3i at baseline and outcome, so only these 7 articles were used for subgroup analysis. Subgroup analysis showed that the MMSE score was significantly improved in the higher baseline O3i subgroup (WMD = 0.553, [0.01, 1.095]; I2 = 0.00%, P(I2) = 0.556) and higher O3i increment subgroup (WMD = 0.525, [0.023, 1.026]; I2 = 0.00%, P(I2) = 0.545). The overall effect demonstrated that n-3 PUFA supplementation exerted no improvement on global cognitive function. However, a higher baseline O3i and higher O3i increment were associated with an improvement in cognitive function in the elderly." @default.
- W4387158896 created "2023-09-30" @default.
- W4387158896 creator A5010738468 @default.
- W4387158896 creator A5015743959 @default.
- W4387158896 creator A5023032911 @default.
- W4387158896 creator A5039677373 @default.
- W4387158896 creator A5041047884 @default.
- W4387158896 creator A5042183753 @default.
- W4387158896 creator A5045158108 @default.
- W4387158896 creator A5057800330 @default.
- W4387158896 creator A5058514856 @default.
- W4387158896 creator A5062807532 @default.
- W4387158896 creator A5074252514 @default.
- W4387158896 creator A5084405961 @default.
- W4387158896 date "2023-01-01" @default.
- W4387158896 modified "2023-10-18" @default.
- W4387158896 title "The effect of n-3 polyunsaturated fatty acid supplementation on cognitive function outcomes in the elderly depends on the baseline omega-3 index" @default.
- W4387158896 cites W1512735145 @default.
- W4387158896 cites W1528771930 @default.
- W4387158896 cites W1971091197 @default.
- W4387158896 cites W1982587661 @default.
- W4387158896 cites W1982779257 @default.
- W4387158896 cites W2015142237 @default.
- W4387158896 cites W2044850402 @default.
- W4387158896 cites W2053519600 @default.
- W4387158896 cites W2053771014 @default.
- W4387158896 cites W2055821827 @default.
- W4387158896 cites W2057006290 @default.
- W4387158896 cites W2075373003 @default.
- W4387158896 cites W2079183773 @default.
- W4387158896 cites W2084566407 @default.
- W4387158896 cites W2109348896 @default.
- W4387158896 cites W2119356619 @default.
- W4387158896 cites W2143209581 @default.
- W4387158896 cites W2149710778 @default.
- W4387158896 cites W2157650384 @default.
- W4387158896 cites W2161817073 @default.
- W4387158896 cites W2212256215 @default.
- W4387158896 cites W2279165743 @default.
- W4387158896 cites W2298887234 @default.
- W4387158896 cites W2346129393 @default.
- W4387158896 cites W2425522378 @default.
- W4387158896 cites W2508202861 @default.
- W4387158896 cites W2529487341 @default.
- W4387158896 cites W2575322336 @default.
- W4387158896 cites W2601075442 @default.
- W4387158896 cites W2605974464 @default.
- W4387158896 cites W2749299089 @default.
- W4387158896 cites W2766839249 @default.
- W4387158896 cites W2793475236 @default.
- W4387158896 cites W2807021305 @default.
- W4387158896 cites W2891165428 @default.
- W4387158896 cites W2914896082 @default.
- W4387158896 cites W2947628883 @default.
- W4387158896 cites W2976855290 @default.
- W4387158896 cites W2983464518 @default.
- W4387158896 cites W2989165838 @default.
- W4387158896 cites W2993755098 @default.
- W4387158896 cites W2996203911 @default.
- W4387158896 cites W2997136313 @default.
- W4387158896 cites W3006021731 @default.
- W4387158896 cites W3015309755 @default.
- W4387158896 cites W3028404978 @default.
- W4387158896 cites W3043270021 @default.
- W4387158896 cites W3047137098 @default.
- W4387158896 cites W3086222697 @default.
- W4387158896 cites W3092181868 @default.
- W4387158896 cites W3111862849 @default.
- W4387158896 cites W3136666843 @default.
- W4387158896 cites W3169717451 @default.
- W4387158896 cites W3209599660 @default.
- W4387158896 cites W3211730108 @default.
- W4387158896 cites W3212143335 @default.
- W4387158896 cites W4224269032 @default.
- W4387158896 cites W4302023492 @default.
- W4387158896 cites W4317399306 @default.
- W4387158896 cites W2972603885 @default.
- W4387158896 doi "https://doi.org/10.1039/d3fo02959j" @default.
- W4387158896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37840364" @default.
- W4387158896 hasPublicationYear "2023" @default.
- W4387158896 type Work @default.
- W4387158896 citedByCount "0" @default.
- W4387158896 crossrefType "journal-article" @default.
- W4387158896 hasAuthorship W4387158896A5010738468 @default.
- W4387158896 hasAuthorship W4387158896A5015743959 @default.
- W4387158896 hasAuthorship W4387158896A5023032911 @default.
- W4387158896 hasAuthorship W4387158896A5039677373 @default.
- W4387158896 hasAuthorship W4387158896A5041047884 @default.
- W4387158896 hasAuthorship W4387158896A5042183753 @default.
- W4387158896 hasAuthorship W4387158896A5045158108 @default.
- W4387158896 hasAuthorship W4387158896A5057800330 @default.
- W4387158896 hasAuthorship W4387158896A5058514856 @default.
- W4387158896 hasAuthorship W4387158896A5062807532 @default.
- W4387158896 hasAuthorship W4387158896A5074252514 @default.
- W4387158896 hasAuthorship W4387158896A5084405961 @default.
- W4387158896 hasConcept C126322002 @default.
- W4387158896 hasConcept C168563851 @default.
- W4387158896 hasConcept C187960798 @default.
- W4387158896 hasConcept C19038510 @default.
- W4387158896 hasConcept C2776478404 @default.