FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387159349> ?p ?o ?g. }

• W4387159349 endingPage "740151" @default.
• W4387159349 startingPage "740151" @default.
• W4387159349 abstract "Better understanding the molecular processes contributing to variation in maturation timing is important for Atlantic salmon (Salmo salar) aquaculture, as early maturation causes considerable financial losses. The m6A RNA methylation is a highly conserved and dynamically reversible mechanism controlling gene expression in a myriad of biological processes. The role of m6A methylation in sexual maturation, however, has remained largely unexplored and has never been studied in Atlantic salmon. While the maturation process is known to be affected by many genetic and environmental factors, the molecular mechanisms causing variation in the timing of maturation are still poorly understood. Hence, investigation of whether a widespread mechanism like m6A methylation could be involved in controlling of the maturation timing is warranted. In Atlantic salmon, two genes, also associated with age at maturity in humans, vgll3 and six6, have been shown to play an important role in maturation timing. In this study, we investigated the expression of 16 genes involved in the regulation of m6A RNA methylation in the hypothalamus of Atlantic salmon with different homozygous combinations of late (L) and early (E) alleles for vgll3 and six6 genes. We found differential expression of ythdf2.2, an m6A reader promoting mRNA degradation, with higher expression in six6*LL compared to other genotypes as well as in immature compared to mature males. In addition, we found that the expression levels of genes coding for an eraser, alkbh5, and for a reader, ythdf1, were higher in the hypothalamus of females than in males across all the different genotypes studied. However the total m6A levels between the whole hypothalamus of males and females were similar. Our results indicate a potential role of the m6A methylation process in sexual maturation of Atlantic salmon, and therefore, provide the first evidence for such regulatory mechanism in the hypothalamus of any vertebrate." @default.
• W4387159349 created "2023-09-30" @default.
• W4387159349 creator A5014350627 @default.
• W4387159349 creator A5025417116 @default.
• W4387159349 creator A5041370768 @default.
• W4387159349 creator A5083685162 @default.
• W4387159349 date "2024-01-01" @default.
• W4387159349 modified "2023-10-16" @default.
• W4387159349 title "Hypothalamic expression analysis of m6A RNA methylation associated genes suggests a potential role of epitransciptomics in sexual maturation of Atlantic salmon" @default.
• W4387159349 cites W1535331051 @default.
• W4387159349 cites W1577577364 @default.
• W4387159349 cites W1941339056 @default.
• W4387159349 cites W1966841534 @default.
• W4387159349 cites W1976378620 @default.
• W4387159349 cites W1996754879 @default.
• W4387159349 cites W2008503061 @default.
• W4387159349 cites W2057531637 @default.
• W4387159349 cites W2059865261 @default.
• W4387159349 cites W2069921878 @default.
• W4387159349 cites W2078964320 @default.
• W4387159349 cites W2099824652 @default.
• W4387159349 cites W2105423509 @default.
• W4387159349 cites W2107665951 @default.
• W4387159349 cites W2108244474 @default.
• W4387159349 cites W2137759860 @default.
• W4387159349 cites W2140124881 @default.
• W4387159349 cites W2150589415 @default.
• W4387159349 cites W2155441570 @default.
• W4387159349 cites W2164095252 @default.
• W4387159349 cites W2165547003 @default.
• W4387159349 cites W2169353806 @default.
• W4387159349 cites W2176478414 @default.
• W4387159349 cites W2282434646 @default.
• W4387159349 cites W2337283254 @default.
• W4387159349 cites W2507685096 @default.
• W4387159349 cites W2515936722 @default.
• W4387159349 cites W2528413731 @default.
• W4387159349 cites W2586247640 @default.
• W4387159349 cites W2592401907 @default.
• W4387159349 cites W2753775066 @default.
• W4387159349 cites W2774934500 @default.
• W4387159349 cites W2807565449 @default.
• W4387159349 cites W2809079841 @default.
• W4387159349 cites W2899339826 @default.
• W4387159349 cites W2902868091 @default.
• W4387159349 cites W2921211860 @default.
• W4387159349 cites W2937072024 @default.
• W4387159349 cites W2950184306 @default.
• W4387159349 cites W2952326309 @default.
• W4387159349 cites W2953041660 @default.
• W4387159349 cites W2972933339 @default.
• W4387159349 cites W2989889106 @default.
• W4387159349 cites W2992866845 @default.
• W4387159349 cites W3005673236 @default.
• W4387159349 cites W3012183536 @default.
• W4387159349 cites W3027037948 @default.
• W4387159349 cites W3027246629 @default.
• W4387159349 cites W3044431885 @default.
• W4387159349 cites W3045353791 @default.
• W4387159349 cites W3047455684 @default.
• W4387159349 cites W3090833238 @default.
• W4387159349 cites W3120616017 @default.
• W4387159349 cites W3135755065 @default.
• W4387159349 cites W3182027579 @default.
• W4387159349 cites W3193157645 @default.
• W4387159349 cites W3205489446 @default.
• W4387159349 cites W3207578891 @default.
• W4387159349 cites W3208898672 @default.
• W4387159349 cites W3216679409 @default.
• W4387159349 cites W3217486891 @default.
• W4387159349 cites W4200114084 @default.
• W4387159349 cites W4200264229 @default.
• W4387159349 cites W4211022341 @default.
• W4387159349 cites W4221068514 @default.
• W4387159349 cites W4225265991 @default.
• W4387159349 cites W4280489902 @default.
• W4387159349 cites W4281258398 @default.
• W4387159349 cites W4281824156 @default.
• W4387159349 cites W4308368002 @default.
• W4387159349 cites W4322718745 @default.
• W4387159349 doi "https://doi.org/10.1016/j.aquaculture.2023.740151" @default.
• W4387159349 hasPublicationYear "2024" @default.
• W4387159349 type Work @default.
• W4387159349 citedByCount "0" @default.
• W4387159349 crossrefType "journal-article" @default.
• W4387159349 hasAuthorship W4387159349A5014350627 @default.
• W4387159349 hasAuthorship W4387159349A5025417116 @default.
• W4387159349 hasAuthorship W4387159349A5041370768 @default.
• W4387159349 hasAuthorship W4387159349A5083685162 @default.
• W4387159349 hasConcept C104317684 @default.
• W4387159349 hasConcept C134018914 @default.
• W4387159349 hasConcept C150194340 @default.
• W4387159349 hasConcept C180754005 @default.
• W4387159349 hasConcept C190727270 @default.
• W4387159349 hasConcept C192536144 @default.
• W4387159349 hasConcept C2777940460 @default.
• W4387159349 hasConcept C2909208804 @default.
• W4387159349 hasConcept C33288867 @default.

• next