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• W4387160314 abstract "Routine clinical practice does not include postoperative positron emission tomography (PET)/CT prior to postoperative radiation therapy (PORT) for head and neck cancer. Besides logistical challenges in obtaining postoperative PET/CT within six weeks after surgery, interpreting PET/CT findings in the postoperative setting can also be difficult. However, given the potential for residual or rapidly recurrent disease, postoperative PET/CT may help identify the need for additional diagnostic evaluation or alter adjuvant therapy. There are limited data evaluating the utility of postoperative PET/CT prior to PORT for head and neck cancer. We sought to evaluate the use and clinical relevance of postoperative PET/CT prior to PORT.In this retrospective, single-institution cohort study, we identified patients with head and neck cancer between 2013 and 2020 who received a postoperative PET/CT prior to PORT. We extracted electronic medical record data supplemented with manual chart review to collect patient and disease-related information. We measured the rates of additional diagnostic workup and treatment alterations as a result of postoperative PET/CT findings.The cohort included 29 patients who received a postoperative PET/CT prior to PORT. The mean age at diagnosis was 60.8 years (standard deviation: 15.0 years) and 20 (69.0%) were male. Regarding primary site, 10 (34.5%) were oropharynx, 7 (24.1%) were salivary gland, and 6 (20.7%) were oral cavity. The mean time from surgery to postoperative PET was 40.9 days (standard deviation: 27.7 days), and the mean time from postoperative PET/CT to start of PORT was 22.4 days (standard deviation: 20.3 days). A total of 9 (31.0%) patients experienced a change in management as a result of the PET/CT findings. Six (66.7%) patients received a biopsy. All 9 patients had a change in their radiation treatment plan, either dose escalation, target change, or in one case, converting to palliative dosing. Six (66.7%) patients were recommended addition of chemotherapy as a result of additional workup, with 4 (44.4%) of those patients ultimately receiving chemotherapy. Three (33.3%) patients underwent re-resection prior to PORT.In patients with head and neck cancer who received postoperative PET/CT prior to PORT, a meaningful proportion underwent additional diagnostic evaluation and/or experienced an alteration in adjuvant therapy as a result of the imaging findings. Interestingly, all patients with abnormal postoperative PET findings had changes in their radiation treatment plan, including at least boosting gross disease for patients in whom re-resection or chemotherapy was not pursued. Future work will seek to expand this cohort through 2022 when postoperative PET/CT became more routine at our institution and include oncologic outcomes. Additional studies are needed to identify appropriate candidates for postoperative PET/CT and determine the clinical impact of postoperative PET/CT." @default.
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• W4387160314 date "2023-10-01" @default.
• W4387160314 modified "2023-10-17" @default.
• W4387160314 title "Use of Postoperative PET/CT in Altering Management in Adjuvant Head and Neck Radiation Therapy" @default.
• W4387160314 doi "https://doi.org/10.1016/j.ijrobp.2023.06.1910" @default.
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