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- W4387160908 abstract "Adjuvant radiotherapy is a crucial treatment option for breast cancer. Owing to the long survival after treatment, heart toxicity has become a critical issue in those who receive radiotherapy. The heart dose is calculated using the computed tomography (CT) images acquired during simulation. The heart volume is quite different between the systolic and diastolic phases. This study used four-dimensional (4D) CT to capture the heart image and determine the ranges of the heart dose in different phases of the heart.Patients with left-sided breast cancer who underwent breast conservative surgery followed by adjuvant radiotherapy to the entire breast between January 2016 and December 2021 were identified. The three-dimensional (3D) CT and 4DCT datasets of the patients were acquired to evaluate the variation in the heart dose. The heart volume in each respiratory phase was depicted in a box plot along with the dice similarity coefficient (DCS).A total of 32 patients met the inclusion criteria. The DCS of the heart in each respiration phase was within the range of 0.91 to 0.95. Variations in the heart volume and morphology were not evident. However, these variations were not influenced by the respiratory cycle. The median relative variations in the 4DCT volume, mean dose, V20 (≥20 Gy), and V40 (40 Gy) were 6%, 14%, 19%, and 32%, respectively. All parameters showed significant variation between the maximum values in 4DCT and planning 3DCT. When parameters in planning 3DCT were compared to minimum values in 4DCT, the heart volume and V20 still showed significant differences, whereas the mean dose (p = .052) and V40 (p = .151) did not.We found that the median variation in the heart volume during the respiratory cycle was 6%, which led to a 14% variation in the mean heart dose, 19% in V20, and 32% in V40. Dose variation should not be ignored. A more precise method for estimating the heart dose during treatment should be investigated." @default.
- W4387160908 created "2023-09-30" @default.
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- W4387160908 date "2023-10-01" @default.
- W4387160908 modified "2023-10-17" @default.
- W4387160908 title "Heart Dose Uncertainty Caused by Heartbeat during Adjuvant Breast Radiotherapy" @default.
- W4387160908 doi "https://doi.org/10.1016/j.ijrobp.2023.06.1092" @default.
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