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- W4387160949 abstract "Trace amines (TAs) in the nervous system bind to TA-associated receptors (TAARs) and are involved in the regulation of monoaminergic functions. Among TAAR subtypes, TAAR1 has been implicated in the development of neurological disorders, such as schizophrenia. The present study investigated the effects of the TAAR1 agonist, 3-iodothyronamine (T1AM) on cerebral arterioles using fluctuations in the intracellular concentration of Ca2+ ([Ca2+]i) as an index of contractile responses. In cerebral arterioles, most of the TAAR agonists did not increase [Ca2+]i, while only T1AM elevated [Ca2+]i in vascular smooth muscle cells. This increase involved extracellular Ca2+ influx through T-type Ca2+ channels and inositol trisphosphate- and ryanodine-receptor-mediated Ca2+ release from intracellular stores. The inhibition of the cAMP sensor, exchange protein directly activated by cAMP (Epac) 2, and calmodulin kinase (CaMK) II strongly inhibited Ca2+ elevations. The present study revealed that T1AM acted not only on the TAAR1 receptor as previously suggested, but also on other G-protein coupled receptors and/or signal transduction systems to increase intracellular Ca2+ in cerebral arteriole smooth muscle cells. These results suggest that when using T1AM in clinical practice, attention should be paid to the early rise in blood pressure." @default.
- W4387160949 created "2023-09-30" @default.
- W4387160949 creator A5030935442 @default.
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- W4387160949 creator A5071638214 @default.
- W4387160949 creator A5088286867 @default.
- W4387160949 date "2023-09-27" @default.
- W4387160949 modified "2023-10-03" @default.
- W4387160949 title "3-Iodothyronamine, a trace amine-associated receptor agonist, regulates intracellular Ca2+ increases via CaMK II through Epac2 in rat cerebral arterioles" @default.
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- W4387160949 doi "https://doi.org/10.2220/biomedres.44.219" @default.
- W4387160949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37779034" @default.
- W4387160949 hasPublicationYear "2023" @default.
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