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• W4387164003 endingPage "161" @default.
• W4387164003 startingPage "139" @default.
• W4387164003 abstract "There are at least 21 families of enveloped viruses that infect mammals, and many contain members of high concern for global human health. All enveloped viruses have a dedicated fusion protein or fusion complex that enacts the critical genome-releasing membrane fusion event that is essential before viral replication within the host cell interior can begin. Because all enveloped viruses enter cells by fusion, it behooves us to know how viral fusion proteins function. Viral fusion proteins are also major targets of neutralizing antibodies, and hence they serve as key vaccine immunogens. Here we review current concepts about viral membrane fusion proteins focusing on how they are triggered, structural intermediates between pre- and postfusion forms, and their interplay with the lipid bilayers they engage. We also discuss cellular and therapeutic interventions that thwart virus-cell membrane fusion." @default.
• W4387164003 created "2023-09-30" @default.
• W4387164003 creator A5021277644 @default.
• W4387164003 creator A5021380299 @default.
• W4387164003 creator A5023685580 @default.
• W4387164003 creator A5079030396 @default.
• W4387164003 date "2023-09-29" @default.
• W4387164003 modified "2023-10-03" @default.
• W4387164003 title "Viral Membrane Fusion: A Dance Between Proteins and Lipids" @default.
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