Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387164568> ?p ?o ?g. }
- W4387164568 abstract "Abstract Two serologically distinct chimpanzee-origin, replication-defective adenovirus (AdC) vectors expressing the spike (S) protein of an early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolate were generated and tested for induction of antibodies in mice. Both vectors induced S protein-specific antibodies including neutralizing antibodies. Levels of antibodies increased after a boost. The effectiveness of the boost depended on vector dose, timing between the two immunizations and the use of homologous versus heterologous AdC vectors. Virus neutralizing antibodies (VNAs) showed only a slight loss of reactivity against variants, which may reflect the pronounced responses against the more conserved S2 subunit of the S protein. Expression of two different S proteins by the AdC vectors used for the prime and the boost did not selectively increase responses against the variants. A vector expressing the fusion peptide of the S2 protein induced highly cross-reactive VNA responses, which, nevertheless, were not sustained." @default.
- W4387164568 created "2023-09-30" @default.
- W4387164568 creator A5007522883 @default.
- W4387164568 creator A5032569174 @default.
- W4387164568 creator A5033662388 @default.
- W4387164568 creator A5039579720 @default.
- W4387164568 creator A5046726096 @default.
- W4387164568 creator A5071568613 @default.
- W4387164568 creator A5087712102 @default.
- W4387164568 creator A5089998149 @default.
- W4387164568 date "2023-09-29" @default.
- W4387164568 modified "2023-09-30" @default.
- W4387164568 title "Pre-clinical testing of two serologically distinct chimpanzee-origin adenovirus vectors expressing spike of SARS-CoV-2" @default.
- W4387164568 cites W1641557591 @default.
- W4387164568 cites W1984204096 @default.
- W4387164568 cites W1990066093 @default.
- W4387164568 cites W1999639343 @default.
- W4387164568 cites W2062891727 @default.
- W4387164568 cites W2084953052 @default.
- W4387164568 cites W2091658591 @default.
- W4387164568 cites W2132260239 @default.
- W4387164568 cites W2141877163 @default.
- W4387164568 cites W2153600773 @default.
- W4387164568 cites W2166867592 @default.
- W4387164568 cites W2738515079 @default.
- W4387164568 cites W2890178834 @default.
- W4387164568 cites W3003668884 @default.
- W4387164568 cites W3004318991 @default.
- W4387164568 cites W3013525829 @default.
- W4387164568 cites W3024602798 @default.
- W4387164568 cites W3042332408 @default.
- W4387164568 cites W3042833857 @default.
- W4387164568 cites W3047091198 @default.
- W4387164568 cites W3083750089 @default.
- W4387164568 cites W3088823112 @default.
- W4387164568 cites W3091443388 @default.
- W4387164568 cites W3092766467 @default.
- W4387164568 cites W3092785765 @default.
- W4387164568 cites W3093367571 @default.
- W4387164568 cites W3114586947 @default.
- W4387164568 cites W3119345685 @default.
- W4387164568 cites W3127329393 @default.
- W4387164568 cites W3136437538 @default.
- W4387164568 cites W3151997765 @default.
- W4387164568 cites W3152490217 @default.
- W4387164568 cites W3175498336 @default.
- W4387164568 cites W3177895433 @default.
- W4387164568 cites W3178327314 @default.
- W4387164568 cites W3187211318 @default.
- W4387164568 cites W3201177512 @default.
- W4387164568 cites W3203248391 @default.
- W4387164568 cites W4206069935 @default.
- W4387164568 cites W4207077414 @default.
- W4387164568 cites W4210279332 @default.
- W4387164568 cites W4210953284 @default.
- W4387164568 cites W4211242522 @default.
- W4387164568 cites W4220668654 @default.
- W4387164568 cites W4220717068 @default.
- W4387164568 cites W4220797730 @default.
- W4387164568 cites W4220988150 @default.
- W4387164568 cites W4223419554 @default.
- W4387164568 cites W4225505755 @default.
- W4387164568 cites W4225592234 @default.
- W4387164568 cites W4280607167 @default.
- W4387164568 cites W4281260975 @default.
- W4387164568 cites W4281665885 @default.
- W4387164568 cites W4282838915 @default.
- W4387164568 cites W4282944799 @default.
- W4387164568 cites W4285041384 @default.
- W4387164568 cites W4306874674 @default.
- W4387164568 cites W4307546751 @default.
- W4387164568 cites W4311582042 @default.
- W4387164568 cites W4312113923 @default.
- W4387164568 cites W4318823624 @default.
- W4387164568 cites W4367834191 @default.
- W4387164568 cites W4376132054 @default.
- W4387164568 cites W4380263769 @default.
- W4387164568 doi "https://doi.org/10.21203/rs.3.rs-3314638/v1" @default.
- W4387164568 hasPublicationYear "2023" @default.
- W4387164568 type Work @default.
- W4387164568 citedByCount "0" @default.
- W4387164568 crossrefType "posted-content" @default.
- W4387164568 hasAuthorship W4387164568A5007522883 @default.
- W4387164568 hasAuthorship W4387164568A5032569174 @default.
- W4387164568 hasAuthorship W4387164568A5033662388 @default.
- W4387164568 hasAuthorship W4387164568A5039579720 @default.
- W4387164568 hasAuthorship W4387164568A5046726096 @default.
- W4387164568 hasAuthorship W4387164568A5071568613 @default.
- W4387164568 hasAuthorship W4387164568A5087712102 @default.
- W4387164568 hasAuthorship W4387164568A5089998149 @default.
- W4387164568 hasBestOaLocation W43871645681 @default.
- W4387164568 hasConcept C104292427 @default.
- W4387164568 hasConcept C104317684 @default.
- W4387164568 hasConcept C159047783 @default.
- W4387164568 hasConcept C159654299 @default.
- W4387164568 hasConcept C203014093 @default.
- W4387164568 hasConcept C2522874641 @default.
- W4387164568 hasConcept C2779261636 @default.
- W4387164568 hasConcept C2780115692 @default.
- W4387164568 hasConcept C32470452 @default.