Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387165175> ?p ?o ?g. }
- W4387165175 abstract "Here we demonstrate, in rodents, how the timing of feeding behaviour becomes disordered when circulating glucocorticoid rhythms are dissociated from lighting cues; a phenomenon most commonly associated with shift-work and transmeridian travel 'jetlag'. Adrenalectomized rats are infused with physiological patterns of corticosterone modelled on the endogenous adrenal secretory profile, either in-phase or out-of-phase with lighting cues. For the in-phase group, food intake is significantly greater during the rats' active period compared to their inactive period; a feeding pattern similar to adrenal-intact control rats. In contrast, the feeding pattern of the out-of-phase group is significantly dysregulated. Consistent with a direct hypothalamic modulation of feeding behaviour, this altered timing is accompanied by dysregulated timing of anorexigenic and orexigenic neuropeptide gene expression. For Neuropeptide Y (Npy), we report a glucocorticoid-dependent direct transcriptional regulation mechanism mediated by the glucocorticoid receptor (GR). Taken together, our data highlight the adverse behavioural outcomes that can arise when two circadian systems have anti-phasic cues, in this case impacting on the glucocorticoid-regulation of a process as fundamental to health as feeding behaviour. Our findings further highlight the need for development of rational approaches in the prevention of metabolic dysfunction in circadian-disrupting activities such as transmeridian travel and shift-work." @default.
- W4387165175 created "2023-09-30" @default.
- W4387165175 creator A5016391083 @default.
- W4387165175 creator A5017571758 @default.
- W4387165175 creator A5039900996 @default.
- W4387165175 creator A5066981475 @default.
- W4387165175 creator A5067830519 @default.
- W4387165175 creator A5082982394 @default.
- W4387165175 creator A5087721477 @default.
- W4387165175 date "2023-09-29" @default.
- W4387165175 modified "2023-10-03" @default.
- W4387165175 title "Phase-shifting the circadian glucocorticoid profile induces disordered feeding behaviour by dysregulating hypothalamic neuropeptide gene expression" @default.
- W4387165175 cites W1590149656 @default.
- W4387165175 cites W191928631 @default.
- W4387165175 cites W1965992252 @default.
- W4387165175 cites W1977904778 @default.
- W4387165175 cites W1990843337 @default.
- W4387165175 cites W1992599322 @default.
- W4387165175 cites W1997510672 @default.
- W4387165175 cites W1997610195 @default.
- W4387165175 cites W2002551520 @default.
- W4387165175 cites W2002941555 @default.
- W4387165175 cites W2031595631 @default.
- W4387165175 cites W2036620114 @default.
- W4387165175 cites W2037938652 @default.
- W4387165175 cites W2040777839 @default.
- W4387165175 cites W2045008807 @default.
- W4387165175 cites W2046445759 @default.
- W4387165175 cites W2048499737 @default.
- W4387165175 cites W2049069390 @default.
- W4387165175 cites W2049578370 @default.
- W4387165175 cites W2054146939 @default.
- W4387165175 cites W2064279675 @default.
- W4387165175 cites W2068973973 @default.
- W4387165175 cites W2074802748 @default.
- W4387165175 cites W2078108617 @default.
- W4387165175 cites W2079998168 @default.
- W4387165175 cites W2080369665 @default.
- W4387165175 cites W2081361091 @default.
- W4387165175 cites W2082219987 @default.
- W4387165175 cites W2086975856 @default.
- W4387165175 cites W2090036936 @default.
- W4387165175 cites W2093685381 @default.
- W4387165175 cites W2094638661 @default.
- W4387165175 cites W2098274706 @default.
- W4387165175 cites W2110243057 @default.
- W4387165175 cites W2129190580 @default.
- W4387165175 cites W2133918896 @default.
- W4387165175 cites W2137087294 @default.
- W4387165175 cites W2139059566 @default.
- W4387165175 cites W2145259134 @default.
- W4387165175 cites W2153433545 @default.
- W4387165175 cites W2154434397 @default.
- W4387165175 cites W2156297391 @default.
- W4387165175 cites W2164824098 @default.
- W4387165175 cites W2165844677 @default.
- W4387165175 cites W2169449436 @default.
- W4387165175 cites W2169458819 @default.
- W4387165175 cites W2170371611 @default.
- W4387165175 cites W2344071048 @default.
- W4387165175 cites W2405727329 @default.
- W4387165175 cites W2472817286 @default.
- W4387165175 cites W2521826648 @default.
- W4387165175 cites W2588155838 @default.
- W4387165175 cites W2588599366 @default.
- W4387165175 cites W2759508077 @default.
- W4387165175 cites W2767497710 @default.
- W4387165175 cites W2797653044 @default.
- W4387165175 cites W2898398260 @default.
- W4387165175 cites W2921539299 @default.
- W4387165175 cites W2954122547 @default.
- W4387165175 cites W3006107828 @default.
- W4387165175 cites W3047879827 @default.
- W4387165175 cites W3143439761 @default.
- W4387165175 cites W3191954139 @default.
- W4387165175 cites W3205123490 @default.
- W4387165175 cites W4213081814 @default.
- W4387165175 cites W4240178698 @default.
- W4387165175 cites W4291950629 @default.
- W4387165175 cites W4294683641 @default.
- W4387165175 cites W4296816736 @default.
- W4387165175 cites W4308687459 @default.
- W4387165175 cites W4308769149 @default.
- W4387165175 cites W4323668433 @default.
- W4387165175 cites W4362657650 @default.
- W4387165175 doi "https://doi.org/10.1038/s42003-023-05347-3" @default.
- W4387165175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37775688" @default.
- W4387165175 hasPublicationYear "2023" @default.
- W4387165175 type Work @default.
- W4387165175 citedByCount "0" @default.
- W4387165175 crossrefType "journal-article" @default.
- W4387165175 hasAuthorship W4387165175A5016391083 @default.
- W4387165175 hasAuthorship W4387165175A5017571758 @default.
- W4387165175 hasAuthorship W4387165175A5039900996 @default.
- W4387165175 hasAuthorship W4387165175A5066981475 @default.
- W4387165175 hasAuthorship W4387165175A5067830519 @default.
- W4387165175 hasAuthorship W4387165175A5082982394 @default.
- W4387165175 hasAuthorship W4387165175A5087721477 @default.
- W4387165175 hasBestOaLocation W43871651751 @default.
- W4387165175 hasConcept C118303440 @default.