Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387165627> ?p ?o ?g. }
- W4387165627 endingPage "100259" @default.
- W4387165627 startingPage "100259" @default.
- W4387165627 abstract "Metal wear and corrosion debris remain a limiting factor for long-term durability of total hip replacement (THR). Common wear particle production techniques for research differ from the actual tribocorrosion processes at the implant site, potentially causing loss of valuable information. The aim of this study was to investigate reactions to freshly generated and time-stabilized particles and ions released from CoCrMo-alloy using a bio-tribometer, which mimics conditions of the periprosthetic environment. THP-1 macrophages were challenged with freshly produced or time-stabilized wear debris. Wear generation took place in a custom-built bio-tribometer inside a CO2 incubator operating with a reciprocating rotation of an Al2O3 ball against a CoCrMo disc. Two different electrochemical conditions with increasingly forced corrosion rates were tested: +0.45 V (passive domain) and + 0.67 V (transition to transpassive domain). Cell viability, proinflammatory cytokines, electrochemical measurements and ICP-MS metal ion content analyses were performed. Cobalt/ chromium concentrations were 6.6/ 1.6 ppm in the passive domain and almost doubled to 11.4/ 3.0 ppm in the passive-transpassive domain. Under those electrochemical conditions, freshly produced and time-stabilized CoCrMo wear decreased cell viability to the same extent. Secretion of proinflammatory cytokines were not significantly different for freshly produced and time-stabilized debris. This study suggests that freshly generated and time-stabilized metal particles/ions cause similar toxicity and inflammatory reactions in macrophages, indicating that standard practices for generating wear debris are valid methods to evaluate wear particle disease. Other cell types, materials, and corrosion potentials need to be studied in the future to solidify the conclusion." @default.
- W4387165627 created "2023-09-30" @default.
- W4387165627 creator A5011662567 @default.
- W4387165627 creator A5028897579 @default.
- W4387165627 creator A5037821265 @default.
- W4387165627 creator A5057383926 @default.
- W4387165627 creator A5075404864 @default.
- W4387165627 date "2023-09-01" @default.
- W4387165627 modified "2023-10-11" @default.
- W4387165627 title "Translational characterization of macrophage responses to stable and non-stable CoCrMo wear and corrosion debris generated in-situ for total hip replacement" @default.
- W4387165627 cites W1512684673 @default.
- W4387165627 cites W172731482 @default.
- W4387165627 cites W1941197925 @default.
- W4387165627 cites W1972971281 @default.
- W4387165627 cites W1980267510 @default.
- W4387165627 cites W1983332596 @default.
- W4387165627 cites W2002847372 @default.
- W4387165627 cites W2016306940 @default.
- W4387165627 cites W2017869529 @default.
- W4387165627 cites W2026687689 @default.
- W4387165627 cites W2028368685 @default.
- W4387165627 cites W2030983764 @default.
- W4387165627 cites W2039496908 @default.
- W4387165627 cites W2056727077 @default.
- W4387165627 cites W2065739756 @default.
- W4387165627 cites W2070346707 @default.
- W4387165627 cites W2080301965 @default.
- W4387165627 cites W2083161108 @default.
- W4387165627 cites W2088113721 @default.
- W4387165627 cites W2095997731 @default.
- W4387165627 cites W2105188510 @default.
- W4387165627 cites W2113223043 @default.
- W4387165627 cites W2121210464 @default.
- W4387165627 cites W2139628971 @default.
- W4387165627 cites W2167431833 @default.
- W4387165627 cites W2476007580 @default.
- W4387165627 cites W2757458382 @default.
- W4387165627 cites W277147851 @default.
- W4387165627 cites W2782623616 @default.
- W4387165627 cites W2790746176 @default.
- W4387165627 cites W2925289814 @default.
- W4387165627 cites W2982461512 @default.
- W4387165627 cites W597233430 @default.
- W4387165627 doi "https://doi.org/10.1016/j.biotri.2023.100259" @default.
- W4387165627 hasPublicationYear "2023" @default.
- W4387165627 type Work @default.
- W4387165627 citedByCount "0" @default.
- W4387165627 crossrefType "journal-article" @default.
- W4387165627 hasAuthorship W4387165627A5011662567 @default.
- W4387165627 hasAuthorship W4387165627A5028897579 @default.
- W4387165627 hasAuthorship W4387165627A5037821265 @default.
- W4387165627 hasAuthorship W4387165627A5057383926 @default.
- W4387165627 hasAuthorship W4387165627A5075404864 @default.
- W4387165627 hasConcept C126322002 @default.
- W4387165627 hasConcept C147789679 @default.
- W4387165627 hasConcept C162681261 @default.
- W4387165627 hasConcept C164027704 @default.
- W4387165627 hasConcept C167310744 @default.
- W4387165627 hasConcept C168646106 @default.
- W4387165627 hasConcept C17525397 @default.
- W4387165627 hasConcept C185592680 @default.
- W4387165627 hasConcept C191897082 @default.
- W4387165627 hasConcept C192562407 @default.
- W4387165627 hasConcept C20625102 @default.
- W4387165627 hasConcept C2776914184 @default.
- W4387165627 hasConcept C2777230088 @default.
- W4387165627 hasConcept C52859227 @default.
- W4387165627 hasConcept C71924100 @default.
- W4387165627 hasConceptScore W4387165627C126322002 @default.
- W4387165627 hasConceptScore W4387165627C147789679 @default.
- W4387165627 hasConceptScore W4387165627C162681261 @default.
- W4387165627 hasConceptScore W4387165627C164027704 @default.
- W4387165627 hasConceptScore W4387165627C167310744 @default.
- W4387165627 hasConceptScore W4387165627C168646106 @default.
- W4387165627 hasConceptScore W4387165627C17525397 @default.
- W4387165627 hasConceptScore W4387165627C185592680 @default.
- W4387165627 hasConceptScore W4387165627C191897082 @default.
- W4387165627 hasConceptScore W4387165627C192562407 @default.
- W4387165627 hasConceptScore W4387165627C20625102 @default.
- W4387165627 hasConceptScore W4387165627C2776914184 @default.
- W4387165627 hasConceptScore W4387165627C2777230088 @default.
- W4387165627 hasConceptScore W4387165627C52859227 @default.
- W4387165627 hasConceptScore W4387165627C71924100 @default.
- W4387165627 hasFunder F4320332161 @default.
- W4387165627 hasLocation W43871656271 @default.
- W4387165627 hasOpenAccess W4387165627 @default.
- W4387165627 hasPrimaryLocation W43871656271 @default.
- W4387165627 hasRelatedWork W178316624 @default.
- W4387165627 hasRelatedWork W1989332198 @default.
- W4387165627 hasRelatedWork W2021156286 @default.
- W4387165627 hasRelatedWork W2064163508 @default.
- W4387165627 hasRelatedWork W2130450803 @default.
- W4387165627 hasRelatedWork W2488088034 @default.
- W4387165627 hasRelatedWork W2509780570 @default.
- W4387165627 hasRelatedWork W2906887393 @default.
- W4387165627 hasRelatedWork W3048514867 @default.
- W4387165627 hasRelatedWork W4385238453 @default.
- W4387165627 isParatext "false" @default.