FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387167752> ?p ?o ?g. }

• W4387167752 abstract "Cancer is a major global health concern, and immune checkpoint inhibitors (ICIs) offer a promising treatment option for cancer patients. However, the efficacy of ICIs can be influenced by various factors, including the use of concomitant medications.We searched databases (PubMed, Embase, Cochrane Library, Web of Science) for systematic reviews and meta-analyses for systematic reviews and meta-analyses on the impact of concomitant medications on ICIs efficacy, published from inception to January 1, 2023. We evaluated the methodological quality of the included meta-analyses, and re-synthesized data using a random-effects model and evidence stratification.We included 23 publications, comprising 11 concomitant medications and 112 associations. Class II-IV evidence suggested that antibiotics have a negative impact on ICIs efficacy. However, ICIs efficacy against melanoma, hepatocellular carcinoma, and esophageal squamous cell carcinoma was not affected, this effect was related to the exposure window (class IV). Class III evidence suggested that proton pump inhibitors have a negative impact on ICIs efficacy; nevertheless, the efficacy against melanoma and renal cell carcinoma was not affected, and the effect was related to exposure before the initiation of ICIs therapy (class II). Although class II/III evidence suggested that steroids have a negative impact, this effect was not observed when used for non-cancer indications and immune-related adverse events (class IV). Class IV evidence suggested that opioids reduce ICIs efficacy, whereas statins and probiotics may improve ICIs efficacy. ICIs efficacy was not affected by histamine 2 receptor antagonists, aspirin, metformin, β-blockers, and nonsteroidal anti-inflammatory agents.Current evidence suggests that the use of antibiotics, PPIs, steroids, and opioids has a negative impact on the efficacy of ICIs. However, this effect may vary depending on the type of tumor, the timing of exposure, and the intended application. Weak evidence suggests that statins and probiotics may enhance the efficacy of ICIs. Aspirin, metformin, β-blockers, and NSAIDs do not appear to affect the efficacy of ICIs. However, caution is advised in interpreting these results due to methodological limitations.https://www.crd.york.ac.uk/PROSPERO,identifier, CRD42022328681." @default.
• W4387167752 created "2023-09-30" @default.
• W4387167752 creator A5007705719 @default.
• W4387167752 creator A5026441939 @default.
• W4387167752 creator A5050215171 @default.
• W4387167752 creator A5070129666 @default.
• W4387167752 creator A5071798264 @default.
• W4387167752 creator A5076363323 @default.
• W4387167752 date "2023-09-29" @default.
• W4387167752 modified "2023-10-18" @default.
• W4387167752 title "Impact of concomitant medications on the efficacy of immune checkpoint inhibitors: an umbrella review" @default.
• W4387167752 cites W1588365385 @default.
• W4387167752 cites W1784175517 @default.
• W4387167752 cites W1909089874 @default.
• W4387167752 cites W1991413098 @default.
• W4387167752 cites W204046373 @default.
• W4387167752 cites W2194591433 @default.
• W4387167752 cites W2289575399 @default.
• W4387167752 cites W2415904000 @default.
• W4387167752 cites W2552593014 @default.
• W4387167752 cites W2560185130 @default.
• W4387167752 cites W2756578555 @default.
• W4387167752 cites W2765314233 @default.
• W4387167752 cites W2765876279 @default.
• W4387167752 cites W2792021903 @default.
• W4387167752 cites W2792076277 @default.
• W4387167752 cites W2892819708 @default.
• W4387167752 cites W2952666958 @default.
• W4387167752 cites W2963082541 @default.
• W4387167752 cites W2966279416 @default.
• W4387167752 cites W2981616900 @default.
• W4387167752 cites W2995658490 @default.
• W4387167752 cites W2996727926 @default.
• W4387167752 cites W3000170484 @default.
• W4387167752 cites W3000696551 @default.
• W4387167752 cites W3006860517 @default.
• W4387167752 cites W3011314376 @default.
• W4387167752 cites W3014912043 @default.
• W4387167752 cites W3022258762 @default.
• W4387167752 cites W3045946240 @default.
• W4387167752 cites W3080758793 @default.
• W4387167752 cites W3091804242 @default.
• W4387167752 cites W3094849016 @default.
• W4387167752 cites W3096233695 @default.
• W4387167752 cites W3100730147 @default.
• W4387167752 cites W3104583693 @default.
• W4387167752 cites W3106005610 @default.
• W4387167752 cites W3111784361 @default.
• W4387167752 cites W3121241747 @default.
• W4387167752 cites W3124384511 @default.
• W4387167752 cites W3126164575 @default.
• W4387167752 cites W3128646645 @default.
• W4387167752 cites W3132217424 @default.
• W4387167752 cites W3135227841 @default.
• W4387167752 cites W3137283383 @default.
• W4387167752 cites W3143467719 @default.
• W4387167752 cites W3152320455 @default.
• W4387167752 cites W3163246668 @default.
• W4387167752 cites W3170170737 @default.
• W4387167752 cites W3174985146 @default.
• W4387167752 cites W3186951264 @default.
• W4387167752 cites W3187798854 @default.
• W4387167752 cites W3189384586 @default.
• W4387167752 cites W3193329895 @default.
• W4387167752 cites W3207597578 @default.
• W4387167752 cites W3212830176 @default.
• W4387167752 cites W4210489086 @default.
• W4387167752 cites W4213341520 @default.
• W4387167752 cites W4213442497 @default.
• W4387167752 cites W4221102549 @default.
• W4387167752 cites W4223609424 @default.
• W4387167752 cites W4225125644 @default.
• W4387167752 cites W4229025196 @default.
• W4387167752 cites W4283733846 @default.
• W4387167752 cites W4284674334 @default.
• W4387167752 cites W4284704584 @default.
• W4387167752 cites W4285611072 @default.
• W4387167752 cites W4288445670 @default.
• W4387167752 cites W4292099965 @default.
• W4387167752 cites W4293553784 @default.
• W4387167752 cites W4296523554 @default.
• W4387167752 cites W4296528597 @default.
• W4387167752 cites W4297229303 @default.
• W4387167752 cites W4300066916 @default.
• W4387167752 cites W4307412537 @default.
• W4387167752 cites W4307488641 @default.
• W4387167752 cites W4308640642 @default.
• W4387167752 cites W4309702675 @default.
• W4387167752 cites W4312018239 @default.
• W4387167752 cites W4317107723 @default.
• W4387167752 cites W4320915200 @default.
• W4387167752 doi "https://doi.org/10.3389/fimmu.2023.1218386" @default.
• W4387167752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37841249" @default.
• W4387167752 hasPublicationYear "2023" @default.
• W4387167752 type Work @default.
• W4387167752 citedByCount "0" @default.
• W4387167752 crossrefType "journal-article" @default.
• W4387167752 hasAuthorship W4387167752A5007705719 @default.
• W4387167752 hasAuthorship W4387167752A5026441939 @default.
• W4387167752 hasAuthorship W4387167752A5050215171 @default.

• next