FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387167952> ?p ?o ?g. }

• W4387167952 abstract "Abstract Purpose: The aim of this study is to investigate the effect of systemic immune inflammation index (SII) on the prognosis, and to determine whether the combination of SII and traditional risk factors could enhance prognosis prediction of locally advanced rectal cancer (LARC). Methods and Materials: We retrospectively reviewed the clinical data of 288 patients with LARC. Clinical variables and hematological parameters of peripheral blood of patients before neoadjuvant chemoradiotherapy were incorporated into further analyses. The primary endpoint was overall survival (OS). According to LASSO penalized Cox and multivariate Cox regression analyses, four independent prognostic risk factors were screened to constructed tow prognostic models and have verified the role of SII in the model. The ROC curve (Receiver operating characteristic ) was applied to determine the optimal cut-off values for SII, and then according to the optimal cut-off value, LARC patients were divided into high- and low-SII groups to perform Kaplan-Meier survival analysis and log-rank tests. Results: Multivariate cox regression (stepwise method) analysis revealed that SII, cN, radiotherapy regimen and received surgery were independent prognostic risk factors. The nomogram model based on the four factors showed that SII shared the largest contributions to prognosis, followed by surgery, cN staging and radiotherapy regimen. The nomogram including SII (AIC, 621.17; C‑index, 0.778) possessed superior prognostic value compared with the nomogram without SII (AIC, 628.35; c-index,0.756). The optimal cut-off value of SII was 587.03 for predicting OS yielded by ROC curve analysis. KM survival analysis showed that the survival of patients with low SII was significantly better than that of patients with high SII (p＜0.0001). Conclusions: The levels of SII before neoadjuvant chemoradiotherapy have important predictive value for the prognosis of patients with LARC, and combining SII with the traditional risk factors may improve predictive performance." @default.
• W4387167952 created "2023-09-30" @default.
• W4387167952 creator A5015732550 @default.
• W4387167952 creator A5016267767 @default.
• W4387167952 creator A5018008926 @default.
• W4387167952 creator A5027861145 @default.
• W4387167952 creator A5028809442 @default.
• W4387167952 creator A5044273874 @default.
• W4387167952 creator A5047621848 @default.
• W4387167952 creator A5049290682 @default.
• W4387167952 creator A5050067556 @default.
• W4387167952 creator A5050145339 @default.
• W4387167952 creator A5053943040 @default.
• W4387167952 creator A5061478390 @default.
• W4387167952 creator A5066892520 @default.
• W4387167952 creator A5067714130 @default.
• W4387167952 creator A5077993378 @default.
• W4387167952 creator A5084229837 @default.
• W4387167952 creator A5090323945 @default.
• W4387167952 creator A5090491104 @default.
• W4387167952 date "2023-09-29" @default.
• W4387167952 modified "2023-09-30" @default.
• W4387167952 title "Establishment and validation of a prognostic model associated with systemic immune inflammatory index (SII) before neoadjuvant chemoradiotherapy in locally advanced rectal cancer" @default.
• W4387167952 cites W1870923212 @default.
• W4387167952 cites W1968519475 @default.
• W4387167952 cites W2049491375 @default.
• W4387167952 cites W2068031166 @default.
• W4387167952 cites W2085187304 @default.
• W4387167952 cites W2089148552 @default.
• W4387167952 cites W2116554142 @default.
• W4387167952 cites W2177971463 @default.
• W4387167952 cites W2270004474 @default.
• W4387167952 cites W2386813197 @default.
• W4387167952 cites W2563208071 @default.
• W4387167952 cites W2737656823 @default.
• W4387167952 cites W2784146546 @default.
• W4387167952 cites W2793017953 @default.
• W4387167952 cites W2923394609 @default.
• W4387167952 cites W2943145086 @default.
• W4387167952 cites W3041341270 @default.
• W4387167952 cites W3111308000 @default.
• W4387167952 cites W3155376172 @default.
• W4387167952 cites W3162062459 @default.
• W4387167952 cites W4214811005 @default.
• W4387167952 cites W4226190119 @default.
• W4387167952 cites W4306250770 @default.
• W4387167952 doi "https://doi.org/10.21203/rs.3.rs-3336246/v1" @default.
• W4387167952 hasPublicationYear "2023" @default.
• W4387167952 type Work @default.
• W4387167952 citedByCount "0" @default.
• W4387167952 crossrefType "posted-content" @default.
• W4387167952 hasAuthorship W4387167952A5015732550 @default.
• W4387167952 hasAuthorship W4387167952A5016267767 @default.
• W4387167952 hasAuthorship W4387167952A5018008926 @default.
• W4387167952 hasAuthorship W4387167952A5027861145 @default.
• W4387167952 hasAuthorship W4387167952A5028809442 @default.
• W4387167952 hasAuthorship W4387167952A5044273874 @default.
• W4387167952 hasAuthorship W4387167952A5047621848 @default.
• W4387167952 hasAuthorship W4387167952A5049290682 @default.
• W4387167952 hasAuthorship W4387167952A5050067556 @default.
• W4387167952 hasAuthorship W4387167952A5050145339 @default.
• W4387167952 hasAuthorship W4387167952A5053943040 @default.
• W4387167952 hasAuthorship W4387167952A5061478390 @default.
• W4387167952 hasAuthorship W4387167952A5066892520 @default.
• W4387167952 hasAuthorship W4387167952A5067714130 @default.
• W4387167952 hasAuthorship W4387167952A5077993378 @default.
• W4387167952 hasAuthorship W4387167952A5084229837 @default.
• W4387167952 hasAuthorship W4387167952A5090323945 @default.
• W4387167952 hasAuthorship W4387167952A5090491104 @default.
• W4387167952 hasBestOaLocation W43871679521 @default.
• W4387167952 hasConcept C10515644 @default.
• W4387167952 hasConcept C105795698 @default.
• W4387167952 hasConcept C121608353 @default.
• W4387167952 hasConcept C126322002 @default.
• W4387167952 hasConcept C143998085 @default.
• W4387167952 hasConcept C161584116 @default.
• W4387167952 hasConcept C2778424827 @default.
• W4387167952 hasConcept C2781413609 @default.
• W4387167952 hasConcept C33923547 @default.
• W4387167952 hasConcept C34626388 @default.
• W4387167952 hasConcept C38180746 @default.
• W4387167952 hasConcept C50382708 @default.
• W4387167952 hasConcept C509974204 @default.
• W4387167952 hasConcept C526805850 @default.
• W4387167952 hasConcept C58471807 @default.
• W4387167952 hasConcept C71924100 @default.
• W4387167952 hasConceptScore W4387167952C10515644 @default.
• W4387167952 hasConceptScore W4387167952C105795698 @default.
• W4387167952 hasConceptScore W4387167952C121608353 @default.
• W4387167952 hasConceptScore W4387167952C126322002 @default.
• W4387167952 hasConceptScore W4387167952C143998085 @default.
• W4387167952 hasConceptScore W4387167952C161584116 @default.
• W4387167952 hasConceptScore W4387167952C2778424827 @default.
• W4387167952 hasConceptScore W4387167952C2781413609 @default.
• W4387167952 hasConceptScore W4387167952C33923547 @default.
• W4387167952 hasConceptScore W4387167952C34626388 @default.
• W4387167952 hasConceptScore W4387167952C38180746 @default.
• W4387167952 hasConceptScore W4387167952C50382708 @default.
• W4387167952 hasConceptScore W4387167952C509974204 @default.
• W4387167952 hasConceptScore W4387167952C526805850 @default.

• next