Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387168380> ?p ?o ?g. }
- W4387168380 abstract "Neutrophils are essential for host defense against Staphylococcus aureus (S. aureus). The neuro-repellent, SLIT2, potently inhibits neutrophil chemotaxis, and might, therefore, be expected to impair antibacterial responses. We report here that, unexpectedly, neutrophils exposed to the N-terminal SLIT2 (N-SLIT2) fragment kill extracellular S. aureus more efficiently. N-SLIT2 amplifies reactive oxygen species production in response to the bacteria by activating p38 mitogen-activated protein kinase that in turn phosphorylates NCF1, an essential subunit of the NADPH oxidase complex. N-SLIT2 also enhances the exocytosis of neutrophil secondary granules. In a murine model of S. aureus skin and soft tissue infection (SSTI), local SLIT2 levels fall initially but increase subsequently, peaking at 3 days after infection. Of note, the neutralization of endogenous SLIT2 worsens SSTI. Temporal fluctuations in local SLIT2 levels may promote neutrophil recruitment and retention at the infection site and hasten bacterial clearance by augmenting neutrophil oxidative burst and degranulation. Collectively, these actions of SLIT2 coordinate innate immune responses to limit susceptibility to S. aureus." @default.
- W4387168380 created "2023-09-30" @default.
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- W4387168380 date "2023-09-29" @default.
- W4387168380 modified "2023-10-11" @default.
- W4387168380 title "The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureus" @default.
- W4387168380 cites W111785239 @default.
- W4387168380 cites W154298887 @default.
- W4387168380 cites W1576411973 @default.
- W4387168380 cites W1597610606 @default.
- W4387168380 cites W1598564250 @default.
- W4387168380 cites W161395021 @default.
- W4387168380 cites W1955938832 @default.
- W4387168380 cites W1968001042 @default.
- W4387168380 cites W1969116899 @default.
- W4387168380 cites W1984500466 @default.
- W4387168380 cites W1984704929 @default.
- W4387168380 cites W2009743745 @default.
- W4387168380 cites W2011473183 @default.
- W4387168380 cites W2014466662 @default.
- W4387168380 cites W2019129382 @default.
- W4387168380 cites W2029387145 @default.
- W4387168380 cites W2034825883 @default.
- W4387168380 cites W2043108620 @default.
- W4387168380 cites W2047112279 @default.
- W4387168380 cites W2047770535 @default.
- W4387168380 cites W2052351454 @default.
- W4387168380 cites W2072230807 @default.
- W4387168380 cites W2072862372 @default.
- W4387168380 cites W2074331191 @default.
- W4387168380 cites W2083373508 @default.
- W4387168380 cites W2087484885 @default.
- W4387168380 cites W2090588873 @default.
- W4387168380 cites W2094578161 @default.
- W4387168380 cites W2097560724 @default.
- W4387168380 cites W2106340568 @default.
- W4387168380 cites W2106913297 @default.
- W4387168380 cites W2108396254 @default.
- W4387168380 cites W2109433253 @default.
- W4387168380 cites W2109709745 @default.
- W4387168380 cites W2110443113 @default.
- W4387168380 cites W2112543741 @default.
- W4387168380 cites W2120728709 @default.
- W4387168380 cites W2125297420 @default.
- W4387168380 cites W2126616449 @default.
- W4387168380 cites W2141218575 @default.
- W4387168380 cites W2151150074 @default.
- W4387168380 cites W2161713324 @default.
- W4387168380 cites W2167279371 @default.
- W4387168380 cites W2314649741 @default.
- W4387168380 cites W2326810932 @default.
- W4387168380 cites W2334267521 @default.
- W4387168380 cites W2395539393 @default.
- W4387168380 cites W2415266727 @default.
- W4387168380 cites W2523423453 @default.
- W4387168380 cites W2567582035 @default.
- W4387168380 cites W2595079717 @default.
- W4387168380 cites W2621098621 @default.
- W4387168380 cites W2625213887 @default.
- W4387168380 cites W2670533836 @default.
- W4387168380 cites W2733861029 @default.
- W4387168380 cites W2738150633 @default.
- W4387168380 cites W2763715289 @default.
- W4387168380 cites W2766118959 @default.
- W4387168380 cites W2768646581 @default.
- W4387168380 cites W2792461570 @default.
- W4387168380 cites W2883039864 @default.
- W4387168380 cites W2904550080 @default.
- W4387168380 cites W2912852672 @default.
- W4387168380 cites W2922357451 @default.
- W4387168380 cites W2947505750 @default.
- W4387168380 cites W2980691057 @default.
- W4387168380 cites W2988192735 @default.
- W4387168380 cites W2994427904 @default.
- W4387168380 cites W3014508302 @default.
- W4387168380 cites W3040774946 @default.
- W4387168380 cites W3049171948 @default.
- W4387168380 cites W3091159762 @default.
- W4387168380 cites W3091567899 @default.
- W4387168380 cites W3103330364 @default.
- W4387168380 cites W3176579240 @default.
- W4387168380 cites W3183102216 @default.