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- W4387168522 abstract "Maintaining diversity in drug development in research into Alzheimer's disease (AD) is necessary to avoid over-reliance on targeting AD neuropathology. Treatments that reduce or prevent the generation of oxidative stress, frequently cited for its causal role in the aging process and AD, could be useful in at-risk populations or diagnosed AD patients. However, in this review, it is argued that clinical research into antioxidants in AD could provide more useful feedback as to the therapeutic value of the oxidative stress theory of AD. Improving comparability between randomized controlled trials (RCTs) is vital from a waste-reduction and priority-setting point of view for AD clinical research. For as well as attempting to improve meaningful outcomes for patients, RCTs of antioxidants in AD should strive to maximize the extraction of clinically useful information and actionable feedback from trial outcomes. Solutions to maximize information flow from RCTs of antioxidants in AD are offered here in the form of checklist questions to improve ongoing and future trials centered around the following dimensions: adhesion to reporting guidelines like CONSORT, biomarker enrichment, simple tests of treatment, and innovative trial design." @default.
- W4387168522 created "2023-09-30" @default.
- W4387168522 creator A5079769411 @default.
- W4387168522 date "2023-09-28" @default.
- W4387168522 modified "2023-10-03" @default.
- W4387168522 title "Improving Clinical Trials of Antioxidants in Alzheimer’s Disease" @default.
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- W4387168522 doi "https://doi.org/10.3233/jad-230308" @default.
- W4387168522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37781800" @default.
- W4387168522 hasPublicationYear "2023" @default.
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