FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387169218> ?p ?o ?g. }

• W4387169218 endingPage "s19" @default.
• W4387169218 startingPage "s18" @default.
• W4387169218 abstract "Background: Antiviral chemoprophylaxis for influenza is recommended in nursing homes to prevent transmission and severe disease among residents with higher risk of severe influenza complications. Interim CDC guidance recommends that long-term care facilities initiate antiviral chemoprophylaxis with oral oseltamivir for all non-ill residents living in the same unit following the start of an outbreak in a facility (ie, ≥2 patients ill within 72 hours and of whom at least 1 resident has laboratory-confirmed influenza). Prophylaxis continues for a minimum of 2 weeks and for at least 7 days after the last laboratory-confirmed case. However, facilities may not strictly adhere to this guidance, with 1 study showing up to 68% of facilities were nonadherent to national guidance (Silva et al 2020). Here, we model the potential impacts of different antiviral prophylaxis strategies. Methods: We developed a susceptible–exposed–asymptomatic–infected–recovered (SEAIR) compartmental model of an average-sized nursing home comprising short-stay residents, long-stay residents, and healthcare personnel (HCP). Persons treated with antiviral chemoprophylaxis were less susceptible to infection, had a lower probability of symptoms if infected, a reduced viral load, and a shortened duration of infectiousness. We included influenza vaccination for residents and HCP through reduced probability of symptomatic infection. Coverage rates were estimated from CDC FluVaxView and CMS COVID-19 nursing home data. As a base case, we modeled a scenario with prophylaxis implemented according to guidance. We varied uptake by residents and HCP (from 10% to 90%), case thresholds for prophylaxis initiation (1–5 cases identified), and timing of prophylaxis cessation: either time dependent (ie, 10–14 days of prophylaxis) or case-dependent (ie, continuing prophylaxis for 1–7 days with no cases). Results: In the scenario based on current guidance, prophylaxis reduced resident cases by 16% and resident hospitalizations by 45%, compared to no prophylaxis (Fig. 1A). Scenarios that differed from the guidance altered case burden and timing: Time-dependent prophylaxis cessation increased resident cases and hospitalizations (Fig. 1A). Timing of prophylaxis initiation had slight effects on the timing of the epidemic and minimal effects on resident cases and hospitalizations (Fig. 1B). High resident uptake was important for reducing resident cases and hospitalizations (Fig. 1C), but increasing HCP uptake had minimal effect (Fig. 1D). Conclusions: Our findings support the current prophylaxis guidance. Promptly implementing prophylaxis reduces resident cases and hospitalizations. Continuing prophylaxis until cases are no longer identified reduces cases and hospitalizations. Disclosure: None" @default.
• W4387169218 created "2023-09-30" @default.
• W4387169218 creator A5032026538 @default.
• W4387169218 creator A5035817952 @default.
• W4387169218 creator A5061518977 @default.
• W4387169218 creator A5064158948 @default.
• W4387169218 creator A5082736291 @default.
• W4387169218 date "2023-06-01" @default.
• W4387169218 modified "2023-09-30" @default.
• W4387169218 title "Modeling the impacts of influenza antiviral prophylaxis strategies in nursing homes" @default.
• W4387169218 doi "https://doi.org/10.1017/ash.2023.234" @default.
• W4387169218 hasPublicationYear "2023" @default.
• W4387169218 type Work @default.
• W4387169218 citedByCount "0" @default.
• W4387169218 crossrefType "journal-article" @default.
• W4387169218 hasAuthorship W4387169218A5032026538 @default.
• W4387169218 hasAuthorship W4387169218A5035817952 @default.
• W4387169218 hasAuthorship W4387169218A5061518977 @default.
• W4387169218 hasAuthorship W4387169218A5064158948 @default.
• W4387169218 hasAuthorship W4387169218A5082736291 @default.
• W4387169218 hasBestOaLocation W43871692181 @default.
• W4387169218 hasConcept C116675565 @default.
• W4387169218 hasConcept C119599485 @default.
• W4387169218 hasConcept C126322002 @default.
• W4387169218 hasConcept C127413603 @default.
• W4387169218 hasConcept C159047783 @default.
• W4387169218 hasConcept C166888038 @default.
• W4387169218 hasConcept C166957645 @default.
• W4387169218 hasConcept C177713679 @default.
• W4387169218 hasConcept C194828623 @default.
• W4387169218 hasConcept C22070199 @default.
• W4387169218 hasConcept C2776688490 @default.
• W4387169218 hasConcept C2776957806 @default.
• W4387169218 hasConcept C2777910003 @default.
• W4387169218 hasConcept C2779134260 @default.
• W4387169218 hasConcept C2780374985 @default.
• W4387169218 hasConcept C3008058167 @default.
• W4387169218 hasConcept C524204448 @default.
• W4387169218 hasConcept C71924100 @default.
• W4387169218 hasConcept C761482 @default.
• W4387169218 hasConcept C95457728 @default.
• W4387169218 hasConceptScore W4387169218C116675565 @default.
• W4387169218 hasConceptScore W4387169218C119599485 @default.
• W4387169218 hasConceptScore W4387169218C126322002 @default.
• W4387169218 hasConceptScore W4387169218C127413603 @default.
• W4387169218 hasConceptScore W4387169218C159047783 @default.
• W4387169218 hasConceptScore W4387169218C166888038 @default.
• W4387169218 hasConceptScore W4387169218C166957645 @default.
• W4387169218 hasConceptScore W4387169218C177713679 @default.
• W4387169218 hasConceptScore W4387169218C194828623 @default.
• W4387169218 hasConceptScore W4387169218C22070199 @default.
• W4387169218 hasConceptScore W4387169218C2776688490 @default.
• W4387169218 hasConceptScore W4387169218C2776957806 @default.
• W4387169218 hasConceptScore W4387169218C2777910003 @default.
• W4387169218 hasConceptScore W4387169218C2779134260 @default.
• W4387169218 hasConceptScore W4387169218C2780374985 @default.
• W4387169218 hasConceptScore W4387169218C3008058167 @default.
• W4387169218 hasConceptScore W4387169218C524204448 @default.
• W4387169218 hasConceptScore W4387169218C71924100 @default.
• W4387169218 hasConceptScore W4387169218C761482 @default.
• W4387169218 hasConceptScore W4387169218C95457728 @default.
• W4387169218 hasIssue "S2" @default.
• W4387169218 hasLocation W43871692181 @default.
• W4387169218 hasOpenAccess W4387169218 @default.
• W4387169218 hasPrimaryLocation W43871692181 @default.
• W4387169218 hasRelatedWork W1620618154 @default.
• W4387169218 hasRelatedWork W1981928469 @default.
• W4387169218 hasRelatedWork W2086169302 @default.
• W4387169218 hasRelatedWork W2096286549 @default.
• W4387169218 hasRelatedWork W2104244770 @default.
• W4387169218 hasRelatedWork W2163987531 @default.
• W4387169218 hasRelatedWork W2379543328 @default.
• W4387169218 hasRelatedWork W3012298354 @default.
• W4387169218 hasRelatedWork W3186973508 @default.
• W4387169218 hasRelatedWork W4295083996 @default.
• W4387169218 hasVolume "3" @default.
• W4387169218 isParatext "false" @default.
• W4387169218 isRetracted "false" @default.
• W4387169218 workType "article" @default.