FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387169350> ?p ?o ?g. }

• W4387169350 endingPage "s13" @default.
• W4387169350 startingPage "s12" @default.
• W4387169350 abstract "Background: Carbapenemase genes in carbapenem-resistant Enterobacterales (CP-CRE) may be transmitted between patients and bacteria. Reported rates of carbapenemase genes vary widely, and it is unclear whether having a carbapenemase gene portends worse outcomes given that all patients with CRE infections have limited treatment options. Methods: Using active population- and laboratory-based active surveillance data collected by the US CDC-funded Georgia Emerging Infections Program from 2011 to 2020, we assessed the frequency of carbapenemase genes in a convenience sample of CRE isolates using whole-genome sequencing (WGS), and we investigated risk factors for carbapenemase positivity. Only the first isolate per patient in a 30-day period was included. We compared characteristics of patients with CP-CRE and non–CP-CRE. Using multivariable log binomial regression, we assessed the association of carbapenemase gene positivity and 90-day mortality. Results: Of 284 CRE isolates, 171 isolates (60.2%) possessed a carbapenemase gene (Table 1), and KPC-3 was the most common carbapenemase gene (80.7%), with only 7 isolates possessing NDM (Table 2). No isolates possessed >1 carbapenemase gene, and most isolates were from urine (82.4%) (Table 1). Carbapenemase gene positivity was associated with lower age, male sex, black race, infection with Klebsiella pneumoniae , polymicrobial infection, having an indwelling medical device, receiving chronic dialysis, and prior stay in a long-term acute-care hospital, long-term care facility, and/or prior hospitalization in the last year. The 90-day mortality rates were similar in patients with non–CP-CRE and CP-CRE: 24.8% versus 25.7% ( P = .86). In multivariable analysis, carbapenemase gene presence was not associated with 90-day mortality (adjusted risk ratio, 0.82; 95% CI, 0.50–1.35) when adjusting for CCI, infection with Klebsiella pneumoniae , and chronic dialysis use. Conclusions: The frequency of CP-CRE among CRE was high in this study, but unlike prior studies, the 90-day mortality rates wer similar in patients with CP-CRE compared to non–CP-CRE. Our results provide novel associations (eg, lower age, male sex, infection with Klebsiella pneumoniae , and indwelling medical devices) that infection preventionists could use to target high-risk patients for screening or isolation prior to CP-CRE detection. Disclosure: None" @default.
• W4387169350 created "2023-09-30" @default.
• W4387169350 creator A5001864647 @default.
• W4387169350 creator A5021419177 @default.
• W4387169350 creator A5047892976 @default.
• W4387169350 creator A5058249059 @default.
• W4387169350 creator A5084794636 @default.
• W4387169350 creator A5092966448 @default.
• W4387169350 date "2023-06-01" @default.
• W4387169350 modified "2023-09-30" @default.
• W4387169350 title "Carbapenemase genes and mortality in patients with carbapenem-resistant Enterobacterales, Atlanta, Georgia, 2011–2020" @default.
• W4387169350 doi "https://doi.org/10.1017/ash.2023.226" @default.
• W4387169350 hasPublicationYear "2023" @default.
• W4387169350 type Work @default.
• W4387169350 citedByCount "0" @default.
• W4387169350 crossrefType "journal-article" @default.
• W4387169350 hasAuthorship W4387169350A5001864647 @default.
• W4387169350 hasAuthorship W4387169350A5021419177 @default.
• W4387169350 hasAuthorship W4387169350A5047892976 @default.
• W4387169350 hasAuthorship W4387169350A5058249059 @default.
• W4387169350 hasAuthorship W4387169350A5084794636 @default.
• W4387169350 hasAuthorship W4387169350A5092966448 @default.
• W4387169350 hasBestOaLocation W43871693501 @default.
• W4387169350 hasConcept C104317684 @default.
• W4387169350 hasConcept C126322002 @default.
• W4387169350 hasConcept C2775992322 @default.
• W4387169350 hasConcept C2776685102 @default.
• W4387169350 hasConcept C2777058267 @default.
• W4387169350 hasConcept C501593827 @default.
• W4387169350 hasConcept C54355233 @default.
• W4387169350 hasConcept C547475151 @default.
• W4387169350 hasConcept C71924100 @default.
• W4387169350 hasConcept C86803240 @default.
• W4387169350 hasConcept C89423630 @default.
• W4387169350 hasConceptScore W4387169350C104317684 @default.
• W4387169350 hasConceptScore W4387169350C126322002 @default.
• W4387169350 hasConceptScore W4387169350C2775992322 @default.
• W4387169350 hasConceptScore W4387169350C2776685102 @default.
• W4387169350 hasConceptScore W4387169350C2777058267 @default.
• W4387169350 hasConceptScore W4387169350C501593827 @default.
• W4387169350 hasConceptScore W4387169350C54355233 @default.
• W4387169350 hasConceptScore W4387169350C547475151 @default.
• W4387169350 hasConceptScore W4387169350C71924100 @default.
• W4387169350 hasConceptScore W4387169350C86803240 @default.
• W4387169350 hasConceptScore W4387169350C89423630 @default.
• W4387169350 hasIssue "S2" @default.
• W4387169350 hasLocation W43871693501 @default.
• W4387169350 hasOpenAccess W4387169350 @default.
• W4387169350 hasPrimaryLocation W43871693501 @default.
• W4387169350 hasRelatedWork W2046444865 @default.
• W4387169350 hasRelatedWork W2083684073 @default.
• W4387169350 hasRelatedWork W2617522945 @default.
• W4387169350 hasRelatedWork W2791224163 @default.
• W4387169350 hasRelatedWork W2889164676 @default.
• W4387169350 hasRelatedWork W2938333462 @default.
• W4387169350 hasRelatedWork W2963257790 @default.
• W4387169350 hasRelatedWork W3010988403 @default.
• W4387169350 hasRelatedWork W3198829514 @default.
• W4387169350 hasRelatedWork W4319755542 @default.
• W4387169350 hasVolume "3" @default.
• W4387169350 isParatext "false" @default.
• W4387169350 isRetracted "false" @default.
• W4387169350 workType "article" @default.