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- W4387172123 abstract "During development and regeneration, cells vigorously migrate to achieve morphogenesis of tissues and organs. Upon these dynamic processes, cells are exposed to various forces such as compression force, stretching force, etc. Although the importance of physical forces in the regulation of morphogenesis has long been discussed, the molecular and cellular mechanism of the force-dependent processes remain largely unknown. We have addressed the problem using embryos of amphibian Xenopus laevis and mouse as well as cultured cells. This series of studies highlighted that physical forces induce remodeling of cell-to-cell adhesion which is in part controlled through the regulation of phase separation. The finding suggests that the cellular response to forces is a mechanochemical feedback system to ensure normal morphogenesis during animal development." @default.
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- W4387172123 date "2023-01-01" @default.
- W4387172123 modified "2023-09-30" @default.
- W4387172123 title "Force-Dependent Remodeling of Cell-to-Cell Adhesion Through the Regulation of Phase Separation" @default.
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- W4387172123 doi "https://doi.org/10.1007/978-981-99-4886-4_9" @default.
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