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- W4387172807 endingPage "368" @default.
- W4387172807 startingPage "343" @default.
- W4387172807 abstract "DNA methylation plays a central role in development serving as a tissue-specific, cell type-specific, and developmental stage-specific memory mark overlaid on genetics, the sequence of the four DNA bases. Both 5-methylcytosine (5mC) and its much less prevalent derivative, 5-hydroxymethylcytosine (5hmC), are found predominantly in the CG dinucleotide (CpG) in vertebrates but their position and density within genic and intergenic sequences exert a powerful influence on biology. The establishment of specific DNA methylation patterns requires DNA methylation and hydroxymethylation writers (DNA methyltransferases and TET enzymes, respectively) and DNA methylation erasers (TET enzymes). The activity of these enzymes at promoters (including CpG island-overlapping promoters) and enhancers is especially important. DNA methylation profiles assert their regulation of transcription via protein readers of DNA methylation or readers of CpG-rich DNA sequences that are unmethylated. The readers of DNA methylation or DNA unmethylation as well as DNA methylation writers and erasers, often are aberrantly expressed, distributed, or mutated in disease and thereby contribute to pathogenesis." @default.
- W4387172807 created "2023-09-30" @default.
- W4387172807 creator A5041376137 @default.
- W4387172807 date "2024-01-01" @default.
- W4387172807 modified "2023-09-30" @default.
- W4387172807 title "DNA methylation and reader or writer proteins: Differentiation and disease" @default.
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