FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387173485> ?p ?o ?g. }

• W4387173485 endingPage "e16088" @default.
• W4387173485 startingPage "e16088" @default.
• W4387173485 abstract "Background Recent efforts to repurpose existing drugs to different indications have been accompanied by a number of computational methods, which incorporate protein-protein interaction networks and signaling pathways, to aid with prioritizing existing targets and/or drugs. However, many of these existing methods are focused on integrating additional data that are only available for a small subset of diseases or conditions. Methods We have designed and implemented a new R-based open-source target prioritization and repurposing method that integrates both canonical intracellular signaling information from five public pathway databases and target information from public sources including OpenTargets.org . The Pathway2Targets algorithm takes a list of significant pathways as input, then retrieves and integrates public data for all targets within those pathways for a given condition. It also incorporates a weighting scheme that is customizable by the user to support a variety of use cases including target prioritization, drug repurposing, and identifying novel targets that are biologically relevant for a different indication. Results As a proof of concept, we applied this algorithm to a public colorectal cancer RNA-sequencing dataset with 144 case and control samples. Our analysis identified 430 targets and ~700 unique drugs based on differential gene expression and signaling pathway enrichment. We found that our highest-ranked predicted targets were significantly enriched in targets with FDA-approved therapeutics for colorectal cancer ( p -value < 0.025) that included EGFR, VEGFA, and PTGS2. Interestingly, there was no statistically significant enrichment of targets for other cancers in this same list suggesting high specificity of the results. We also adjusted the weighting scheme to prioritize more novel targets for CRC. This second analysis revealed epidermal growth factor receptor (EGFR), phosphoinositide-3-kinase (PI3K), and two mitogen-activated protein kinases (MAPK14 and MAPK3). These observations suggest that our open-source method with a customizable weighting scheme can accurately prioritize targets that are specific and relevant to the disease or condition of interest, as well as targets that are at earlier stages of development. We anticipate that this method will complement other approaches to repurpose drugs for a variety of indications, which can contribute to the improvement of the quality of life and overall health of such patients." @default.
• W4387173485 created "2023-09-30" @default.
• W4387173485 creator A5000509612 @default.
• W4387173485 creator A5016079026 @default.
• W4387173485 creator A5056498531 @default.
• W4387173485 creator A5081038591 @default.
• W4387173485 creator A5092967647 @default.
• W4387173485 creator A5092967648 @default.
• W4387173485 date "2023-09-29" @default.
• W4387173485 modified "2023-10-05" @default.
• W4387173485 title "Pathway2Targets: an open-source pathway-based approach to repurpose therapeutic drugs and prioritize human targets" @default.
• W4387173485 cites W1915169854 @default.
• W4387173485 cites W1976544205 @default.
• W4387173485 cites W1981409633 @default.
• W4387173485 cites W2000709800 @default.
• W4387173485 cites W2016914833 @default.
• W4387173485 cites W2082399236 @default.
• W4387173485 cites W2096766502 @default.
• W4387173485 cites W2110687686 @default.
• W4387173485 cites W2110967174 @default.
• W4387173485 cites W2113951828 @default.
• W4387173485 cites W2114104545 @default.
• W4387173485 cites W2119629574 @default.
• W4387173485 cites W2123724865 @default.
• W4387173485 cites W2125118217 @default.
• W4387173485 cites W2146416540 @default.
• W4387173485 cites W2154458783 @default.
• W4387173485 cites W2168764383 @default.
• W4387173485 cites W2396460101 @default.
• W4387173485 cites W2410743230 @default.
• W4387173485 cites W2489003193 @default.
• W4387173485 cites W2528904141 @default.
• W4387173485 cites W2559466477 @default.
• W4387173485 cites W2591347142 @default.
• W4387173485 cites W2592811885 @default.
• W4387173485 cites W2770849724 @default.
• W4387173485 cites W2794479004 @default.
• W4387173485 cites W2811431973 @default.
• W4387173485 cites W2885031867 @default.
• W4387173485 cites W2889157692 @default.
• W4387173485 cites W2901693110 @default.
• W4387173485 cites W2902095884 @default.
• W4387173485 cites W2909137860 @default.
• W4387173485 cites W2911194457 @default.
• W4387173485 cites W2913847824 @default.
• W4387173485 cites W2914135414 @default.
• W4387173485 cites W2914863996 @default.
• W4387173485 cites W2916879436 @default.
• W4387173485 cites W2916884534 @default.
• W4387173485 cites W2918104070 @default.
• W4387173485 cites W2921141022 @default.
• W4387173485 cites W2921643592 @default.
• W4387173485 cites W2921922051 @default.
• W4387173485 cites W2936686072 @default.
• W4387173485 cites W2939519112 @default.
• W4387173485 cites W2945027804 @default.
• W4387173485 cites W2950473735 @default.
• W4387173485 cites W2951512731 @default.
• W4387173485 cites W2952794296 @default.
• W4387173485 cites W2953945894 @default.
• W4387173485 cites W2957253824 @default.
• W4387173485 cites W2958740395 @default.
• W4387173485 cites W2965506096 @default.
• W4387173485 cites W2968059852 @default.
• W4387173485 cites W2969609247 @default.
• W4387173485 cites W2972267410 @default.
• W4387173485 cites W2983649157 @default.
• W4387173485 cites W2984070637 @default.
• W4387173485 cites W2984668549 @default.
• W4387173485 cites W2986500860 @default.
• W4387173485 cites W2989611985 @default.
• W4387173485 cites W2991107502 @default.
• W4387173485 cites W2994900199 @default.
• W4387173485 cites W2998462049 @default.
• W4387173485 cites W3002573892 @default.
• W4387173485 cites W3004419054 @default.
• W4387173485 cites W3005664089 @default.
• W4387173485 cites W3009097360 @default.
• W4387173485 cites W3011140609 @default.
• W4387173485 cites W3011178559 @default.
• W4387173485 cites W3011200991 @default.
• W4387173485 cites W3014876791 @default.
• W4387173485 cites W3016524275 @default.
• W4387173485 cites W3020998435 @default.
• W4387173485 cites W3033000020 @default.
• W4387173485 cites W3037750477 @default.
• W4387173485 cites W3045706461 @default.
• W4387173485 cites W3046419426 @default.
• W4387173485 cites W3046562558 @default.
• W4387173485 cites W3046925633 @default.
• W4387173485 cites W3049314860 @default.
• W4387173485 cites W3051693141 @default.
• W4387173485 cites W3089333769 @default.
• W4387173485 cites W3093253498 @default.
• W4387173485 cites W3094492244 @default.
• W4387173485 cites W3106143834 @default.
• W4387173485 cites W3114441930 @default.
• W4387173485 cites W3120640500 @default.

• next