Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387173612> ?p ?o ?g. }
- W4387173612 abstract "Abstract Astrocytes play crucial roles in brain homeostasis and are regulatory elements of neuronal and synaptic physiology. Astrocytic alterations have been found in Major Depressive Disorder (MDD) patients; however, the consequences of astrocyte Ca 2+ signaling in MDD are poorly understood. Here, we found that corticosterone-treated juvenile mice (Cort-mice) showed altered astrocytic Ca 2+ dynamics in mPFC both in resting conditions and during social interactions, in line with altered mice behavior. Additionally, Cort-mice displayed reduced serotonin (5-HT)-mediated Ca 2+ signaling in mPFC astrocytes, and aberrant 5-HT-driven synaptic plasticity in layer 2/3 mPFC neurons. Downregulation of astrocyte Ca 2+ signaling in naïve animals mimicked the synaptic deficits found in Cort-mice. Remarkably, boosting astrocyte Ca 2+ signaling with Gq-DREADDS restored to the control levels mood and cognitive abilities in Cort-mice. This study highlights the important role of astrocyte Ca 2+ signaling for homeostatic control of brain circuits and behavior, but also reveals its potential therapeutic value for depressive-like states." @default.
- W4387173612 created "2023-09-30" @default.
- W4387173612 creator A5009493618 @default.
- W4387173612 creator A5011011292 @default.
- W4387173612 creator A5013615025 @default.
- W4387173612 creator A5030352667 @default.
- W4387173612 creator A5038161179 @default.
- W4387173612 creator A5039848937 @default.
- W4387173612 creator A5059410085 @default.
- W4387173612 creator A5064662930 @default.
- W4387173612 creator A5077838902 @default.
- W4387173612 date "2023-09-29" @default.
- W4387173612 modified "2023-10-16" @default.
- W4387173612 title "Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states" @default.
- W4387173612 cites W1501727007 @default.
- W4387173612 cites W156771624 @default.
- W4387173612 cites W1646393677 @default.
- W4387173612 cites W1875506666 @default.
- W4387173612 cites W1901485302 @default.
- W4387173612 cites W1906859819 @default.
- W4387173612 cites W1910201310 @default.
- W4387173612 cites W1962252580 @default.
- W4387173612 cites W1972077052 @default.
- W4387173612 cites W1973386992 @default.
- W4387173612 cites W1976314299 @default.
- W4387173612 cites W1976738806 @default.
- W4387173612 cites W1977514547 @default.
- W4387173612 cites W1977593923 @default.
- W4387173612 cites W1980153635 @default.
- W4387173612 cites W1981875451 @default.
- W4387173612 cites W1983245960 @default.
- W4387173612 cites W1985645068 @default.
- W4387173612 cites W1988466178 @default.
- W4387173612 cites W1989972218 @default.
- W4387173612 cites W1992958350 @default.
- W4387173612 cites W1993716644 @default.
- W4387173612 cites W1993860176 @default.
- W4387173612 cites W1996996429 @default.
- W4387173612 cites W2003982930 @default.
- W4387173612 cites W2007636259 @default.
- W4387173612 cites W2011566601 @default.
- W4387173612 cites W2011603932 @default.
- W4387173612 cites W2011786285 @default.
- W4387173612 cites W2012053067 @default.
- W4387173612 cites W2016292245 @default.
- W4387173612 cites W2023081218 @default.
- W4387173612 cites W2024017610 @default.
- W4387173612 cites W2032378574 @default.
- W4387173612 cites W2032857027 @default.
- W4387173612 cites W2042681276 @default.
- W4387173612 cites W2047969260 @default.
- W4387173612 cites W2048105028 @default.
- W4387173612 cites W2054980594 @default.
- W4387173612 cites W2056776711 @default.
- W4387173612 cites W2058500729 @default.
- W4387173612 cites W2060938551 @default.
- W4387173612 cites W2067102106 @default.
- W4387173612 cites W2070408678 @default.
- W4387173612 cites W2070615835 @default.
- W4387173612 cites W2074483296 @default.
- W4387173612 cites W2074967846 @default.
- W4387173612 cites W2076201141 @default.
- W4387173612 cites W2076310752 @default.
- W4387173612 cites W2079369179 @default.
- W4387173612 cites W2083221115 @default.
- W4387173612 cites W2083739539 @default.
- W4387173612 cites W2091512835 @default.
- W4387173612 cites W2109909801 @default.
- W4387173612 cites W2110572089 @default.
- W4387173612 cites W2111547035 @default.
- W4387173612 cites W2120279490 @default.
- W4387173612 cites W2123503571 @default.
- W4387173612 cites W2130525167 @default.
- W4387173612 cites W2142717029 @default.
- W4387173612 cites W2145015359 @default.
- W4387173612 cites W2150002111 @default.
- W4387173612 cites W2151595908 @default.
- W4387173612 cites W2153795414 @default.
- W4387173612 cites W2166370054 @default.
- W4387173612 cites W2172253369 @default.
- W4387173612 cites W2199203598 @default.
- W4387173612 cites W2259648020 @default.
- W4387173612 cites W2269038554 @default.
- W4387173612 cites W2271790357 @default.
- W4387173612 cites W2276857175 @default.
- W4387173612 cites W2296134596 @default.
- W4387173612 cites W2341692630 @default.
- W4387173612 cites W2511946169 @default.
- W4387173612 cites W2516100705 @default.
- W4387173612 cites W2562109833 @default.
- W4387173612 cites W2566853258 @default.
- W4387173612 cites W2580929144 @default.
- W4387173612 cites W2601196285 @default.
- W4387173612 cites W2603258172 @default.
- W4387173612 cites W2621092050 @default.
- W4387173612 cites W2625872185 @default.
- W4387173612 cites W2695471189 @default.
- W4387173612 cites W2729142200 @default.
- W4387173612 cites W2730900010 @default.
- W4387173612 cites W2745223669 @default.