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- W4387174911 abstract "Malaria: Host proteins linked to severity of disease The distinction between severe malaria and uncomplicated malaria has been linked to different levels of two gene-regulating proteins. The proteins GATA3 and T-bet are “transcription factors” which bind to DNA and control the activity of specific genes. These host proteins are known to regulate the production of interleukin-10 (IL-10), an anti-inflammatory protein produced in response to infections. Shashi Baruah and Anusree Mahanta at Tezpur University in India previously found lower levels of IL-10 in severe malaria. They therefore looked for a direct link between GATA3, T-bet and IL-10 in patients with severe malaria and uncomplicated malaria. Their results suggest that the Plasmodium falciparum microorganism that causes malaria actively depresses levels of GATA3 and T-bet in the severe form of the disease. Probing the mechanism of this effect might suggest therapies to reduce the resulting inflammation." @default.
- W4387174911 created "2023-09-30" @default.
- W4387174911 date "2015-11-01" @default.
- W4387174911 modified "2023-09-30" @default.
- W4387174911 doi "https://doi.org/10.1002/cti2.2015.4.issue-11" @default.
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