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- W4387183780 abstract "Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency. CVID is a heterogeneous disorder with a presumed multifactorial etiology. Intravenous or subcutaneous immunoglobulin replacement therapy (IgRT) can prevent severe infections but not underlying immune dysregulation.In this study, we evaluated the serum concentrations of proinflammatory (TNF-α, IL-1β, IL-6) and immunoregulatory cytokines (IL-10), as well as lipopolysaccharide (LPS) and soluble CD14 (sCD14) in CVID individuals with infectious only (INF-CVID), and those with additional systemic autoimmune and inflammatory disorders (NIC-CVID), and healthy donors (HD).Our results showed increased serum concentrations of TNF-α, IL-1β, IL-6, and IL-10 in both INF-CVID and NIC-CVID subjects compared to HD. However, elevations of TNF-α, IL-1β, IL-6, and IL-10 were significantly more marked in NIC-CVID than INF-CVID. Additionally, LPS concentrations were increased only in NIC-CVID but not in INF-CVID compared to HD. Circulating levels of sCD14 were significantly increased in NIC-CVID compared to both INF-CVID and HD.These findings indicate persistent cytokine dysregulation despite IgRT in individuals with CVID. Moreover, the circulating cytokine profile reveals the heterogeneity of immune dysregulation in different subgroups of CVID subjects." @default.
- W4387183780 created "2023-09-30" @default.
- W4387183780 creator A5013748934 @default.
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- W4387183780 creator A5092968393 @default.
- W4387183780 date "2023-09-28" @default.
- W4387183780 modified "2023-10-18" @default.
- W4387183780 title "Cytokine dysregulation despite immunoglobulin replacement therapy in common variable immunodeficiency (CVID)" @default.
- W4387183780 cites W107440791 @default.
- W4387183780 cites W1506126816 @default.
- W4387183780 cites W1584774122 @default.
- W4387183780 cites W1605796307 @default.
- W4387183780 cites W1707729952 @default.
- W4387183780 cites W1837754201 @default.
- W4387183780 cites W1964369102 @default.
- W4387183780 cites W1966265903 @default.
- W4387183780 cites W1978562653 @default.
- W4387183780 cites W1983366728 @default.
- W4387183780 cites W1995839977 @default.
- W4387183780 cites W1995924318 @default.
- W4387183780 cites W2030260342 @default.
- W4387183780 cites W2035451300 @default.
- W4387183780 cites W2052044919 @default.
- W4387183780 cites W2056778161 @default.
- W4387183780 cites W2062305977 @default.
- W4387183780 cites W2065367239 @default.
- W4387183780 cites W2070117107 @default.
- W4387183780 cites W2074006404 @default.
- W4387183780 cites W2074570995 @default.
- W4387183780 cites W2075047806 @default.
- W4387183780 cites W2081682401 @default.
- W4387183780 cites W2089628353 @default.
- W4387183780 cites W2090132252 @default.
- W4387183780 cites W2090163159 @default.
- W4387183780 cites W2095804489 @default.
- W4387183780 cites W2098152094 @default.
- W4387183780 cites W2098542011 @default.
- W4387183780 cites W2099658042 @default.
- W4387183780 cites W2099872624 @default.
- W4387183780 cites W2103754915 @default.
- W4387183780 cites W2109491705 @default.
- W4387183780 cites W2113828544 @default.
- W4387183780 cites W2131060369 @default.
- W4387183780 cites W2147024250 @default.
- W4387183780 cites W2154926046 @default.
- W4387183780 cites W2155266621 @default.
- W4387183780 cites W2155465036 @default.
- W4387183780 cites W2156913850 @default.
- W4387183780 cites W2169502237 @default.
- W4387183780 cites W2218595127 @default.
- W4387183780 cites W2235970093 @default.
- W4387183780 cites W2253670074 @default.
- W4387183780 cites W2259709647 @default.
- W4387183780 cites W2261751990 @default.
- W4387183780 cites W2296072626 @default.
- W4387183780 cites W2298390267 @default.
- W4387183780 cites W2562948953 @default.
- W4387183780 cites W2564714625 @default.
- W4387183780 cites W2590609776 @default.
- W4387183780 cites W2621213071 @default.
- W4387183780 cites W2621980896 @default.
- W4387183780 cites W2729839477 @default.
- W4387183780 cites W2755634342 @default.
- W4387183780 cites W2783068730 @default.
- W4387183780 cites W2791800825 @default.
- W4387183780 cites W2803310861 @default.
- W4387183780 cites W2807906301 @default.
- W4387183780 cites W2809104512 @default.
- W4387183780 cites W2883146779 @default.
- W4387183780 cites W2894451493 @default.
- W4387183780 cites W2900420979 @default.
- W4387183780 cites W2900835420 @default.
- W4387183780 cites W2905026338 @default.
- W4387183780 cites W2938341288 @default.
- W4387183780 cites W2947701233 @default.
- W4387183780 cites W2964477554 @default.
- W4387183780 cites W2990679542 @default.
- W4387183780 cites W2995198399 @default.
- W4387183780 cites W3001442764 @default.
- W4387183780 cites W3004561928 @default.
- W4387183780 cites W3005149830 @default.
- W4387183780 cites W3036120527 @default.
- W4387183780 cites W3044316568 @default.
- W4387183780 cites W3101673381 @default.
- W4387183780 cites W3119356936 @default.
- W4387183780 cites W3123033408 @default.
- W4387183780 cites W3134111715 @default.
- W4387183780 cites W3159275106 @default.
- W4387183780 cites W3161353558 @default.
- W4387183780 cites W3166011966 @default.
- W4387183780 cites W3183772665 @default.
- W4387183780 cites W3188048417 @default.
- W4387183780 cites W3215783783 @default.
- W4387183780 cites W4200412502 @default.