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• W4387183798 abstract "Abstract The Lyme disease spirochete Borrelia burgdorferi drives a range of acute and chronic maladies in humans and other incidental hosts infected with the pathogen. However, a primary vertebrate reservoir, Peromyscus leucopus appears spared from any symptomology following infection. This has led to a common assumption that P. leucopus and B. burgdorferi exist symbiotically: P. leucopus restrain their immune response against the microbe and enable the enzootic cycle while B. burgdorferi avoids causing damage to the host. While aspects of this hypothesis have been tested, the exact interactions that occur between P. leucopus and B. burgdorferi during infection remain largely unknown. Here we compared infection of P. leucopus with B. burgdorferi with infection of the traditional B. burgdorferi murine models—C57BL/6J and C3H/HeN Mus musculus , which develop signs of inflammation akin to human disease. We find that in contrast to our expectations, B. burgdorferi were able to reach much higher burdens in M. musculus , and that the overall kinetics of infection differed between the two rodent species. Surprisingly, we also found that P. leucopus remained infectious to larval Ixodes scapularis for a far shorter period than either M. musculus strain. In line with these observations, we found that P. leucopus does launch a modest but sustained inflammatory response against B. burgdorferi in the skin, which we hypothesize leads to reduced bacterial viability and infectivity in these hosts. These observations provide new insight into the nature of reservoir species and the B. burgdorferi enzootic cycle. Author Summary The bacteria that causes Lyme disease, Borrelia burgdorferi , must alternate between infecting a vertebrate host—usually rodents or birds—and ticks. In order to be successful in that endeavor the bacteria must avoid being killed by the vertebrate host before it can infect a new larval tick. In this work we examine how B. burgdorferi and one of its primary vertebrate reservoirs, Peromyscus leucopus , interact during an experimental infection and find contrary to expectations B. burgdorferi appear to colonize its natural host worse than conventional lab mouse models. These data question long-held assumptions about P. leucopus immunology and could potentially serve as a foundation to uncover ways to disrupt the spread of B. burgdorferi in nature." @default.
• W4387183798 created "2023-09-30" @default.
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• W4387183798 date "2023-09-28" @default.
• W4387183798 modified "2023-10-06" @default.
• W4387183798 title "Comparative reservoir competence of Peromyscus leucopus and mouse models for Borrelia burgdorferi B31" @default.
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• W4387183798 doi "https://doi.org/10.1101/2023.09.28.559638" @default.
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