Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387183837> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4387183837 abstract "Three-dimensional structure information, now available at the proteome scale, may facilitate the detection of remote evolutionary relationships in protein superfamilies. Here, we illustrate this with the identification of a novel family of protein domains related to the ferredoxin-like superfold, by combining (i) transitive sequence similarity searches, (ii) clustering approaches and (iii) the use of AlphaFold2 3D structure models. Domains of this family called CoBaHMA, were initially identified in relation with the intracellular biomineralization of calcium carbonates by Cyanobacteria. They are part of the large heavy-metal-associated (HMA) superfamily, departing from the latter by specific sequence and structural features. In particular, most CoBaHMA domains share conserved basic amino acids, forming a positively charged surface, which is likely to interact with anionic partners. CoBaHMA domains are found in diverse modular organizations in bacteria, existing in the form of monodomain proteins or as part of larger proteins, some of which are membrane proteins involved in transport or lipid metabolism. This suggests that the CoBaHMA domains may exert a regulatory function, involving interactions with anionic lipids. This hypothesis might have a particular resonance in the context of the compartmentalization observed for cyanobacterial intracellular calcium carbonates." @default.
- W4387183837 created "2023-09-30" @default.
- W4387183837 creator A5001303309 @default.
- W4387183837 creator A5009083062 @default.
- W4387183837 creator A5024388396 @default.
- W4387183837 creator A5042740302 @default.
- W4387183837 creator A5044290093 @default.
- W4387183837 creator A5078854671 @default.
- W4387183837 creator A5083064307 @default.
- W4387183837 creator A5085985957 @default.
- W4387183837 date "2023-09-29" @default.
- W4387183837 modified "2023-09-30" @default.
- W4387183837 title "AlphaFold2-guided description of CoBaHMA, a novel family of bacterial domains within the Heavy-Metal Associated superfamily" @default.
- W4387183837 doi "https://doi.org/10.22541/au.169596218.88011536/v1" @default.
- W4387183837 hasPublicationYear "2023" @default.
- W4387183837 type Work @default.
- W4387183837 citedByCount "0" @default.
- W4387183837 crossrefType "posted-content" @default.
- W4387183837 hasAuthorship W4387183837A5001303309 @default.
- W4387183837 hasAuthorship W4387183837A5009083062 @default.
- W4387183837 hasAuthorship W4387183837A5024388396 @default.
- W4387183837 hasAuthorship W4387183837A5042740302 @default.
- W4387183837 hasAuthorship W4387183837A5044290093 @default.
- W4387183837 hasAuthorship W4387183837A5078854671 @default.
- W4387183837 hasAuthorship W4387183837A5083064307 @default.
- W4387183837 hasAuthorship W4387183837A5085985957 @default.
- W4387183837 hasBestOaLocation W43871838371 @default.
- W4387183837 hasConcept C104317684 @default.
- W4387183837 hasConcept C104397665 @default.
- W4387183837 hasConcept C110455231 @default.
- W4387183837 hasConcept C14036430 @default.
- W4387183837 hasConcept C151730666 @default.
- W4387183837 hasConcept C171897839 @default.
- W4387183837 hasConcept C181199279 @default.
- W4387183837 hasConcept C2779343474 @default.
- W4387183837 hasConcept C47701112 @default.
- W4387183837 hasConcept C55493867 @default.
- W4387183837 hasConcept C58773245 @default.
- W4387183837 hasConcept C70721500 @default.
- W4387183837 hasConcept C78458016 @default.
- W4387183837 hasConcept C86803240 @default.
- W4387183837 hasConcept C92028520 @default.
- W4387183837 hasConceptScore W4387183837C104317684 @default.
- W4387183837 hasConceptScore W4387183837C104397665 @default.
- W4387183837 hasConceptScore W4387183837C110455231 @default.
- W4387183837 hasConceptScore W4387183837C14036430 @default.
- W4387183837 hasConceptScore W4387183837C151730666 @default.
- W4387183837 hasConceptScore W4387183837C171897839 @default.
- W4387183837 hasConceptScore W4387183837C181199279 @default.
- W4387183837 hasConceptScore W4387183837C2779343474 @default.
- W4387183837 hasConceptScore W4387183837C47701112 @default.
- W4387183837 hasConceptScore W4387183837C55493867 @default.
- W4387183837 hasConceptScore W4387183837C58773245 @default.
- W4387183837 hasConceptScore W4387183837C70721500 @default.
- W4387183837 hasConceptScore W4387183837C78458016 @default.
- W4387183837 hasConceptScore W4387183837C86803240 @default.
- W4387183837 hasConceptScore W4387183837C92028520 @default.
- W4387183837 hasLocation W43871838371 @default.
- W4387183837 hasOpenAccess W4387183837 @default.
- W4387183837 hasPrimaryLocation W43871838371 @default.
- W4387183837 hasRelatedWork W1543932334 @default.
- W4387183837 hasRelatedWork W1967807546 @default.
- W4387183837 hasRelatedWork W1989644067 @default.
- W4387183837 hasRelatedWork W2003188264 @default.
- W4387183837 hasRelatedWork W2043242029 @default.
- W4387183837 hasRelatedWork W2061259593 @default.
- W4387183837 hasRelatedWork W2075451617 @default.
- W4387183837 hasRelatedWork W2128653811 @default.
- W4387183837 hasRelatedWork W2952639490 @default.
- W4387183837 hasRelatedWork W3202271322 @default.
- W4387183837 isParatext "false" @default.
- W4387183837 isRetracted "false" @default.
- W4387183837 workType "article" @default.